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BACKGROUND: Polyglutamine (polyQ) diseases are characterised by the expansion of CAG triplet repeats in specific genes. The accumulated encoded proteins affect the transcription of numerous transcription factors. We investigated whether polyQ diseases reduce the risk of cancer development. METHODS: Data on patients with the polyQ diseases Huntington's disease (HD), spinobulbar muscular atrophy (

The clinical trials with intrastriatal transplantation of human fetal mesencephalic tissue, rich in dopaminergic neurons, in Parkinson's disease (PD) patients show that cell replacement can work and in some cases induce major, long-lasting improvement. However, owing to poor tissue availability, this approach can only be applied in very few patients, and standardization is difficult, leading to wi

It is well-known that the participation in a design process can be experienced as being so meaningful that the participation in itself overshadows even the result of that process. The participants in this design project represent a user group that often use products in which functional value is pre-eminent: people with disabilities. Thereby special attention has been given to the concepts of stigm

In the upper airway, the production of antimicrobial peptides (AMPs) protects against bacteria, viruses and fungi. Previous investigations have revealed downregulated expression of AMPs in different manifestations of allergic disease. In this study, we examined the expression of LL-37, RNase7 and LEAP-2 in tonsillar tissue and studied a possible relation to seasonal allergic rhinitis (SAR).

The message conveyed by the Intergovernmental Panel on Climate Change (IPCC) is clear: the global climate crisis has arrived (e.g., IPCC, 2007, 2014). It is commonly understood that responding to this crisis requires coordinated actions at a global level (Weischer et al., 2012, p. 117; Kulovesi, 2012, p. 193). Attempts to slow down the increase in global temperature, as well as to organize and exc

The placenta must not only provide nutrients and take care of fetal waste products, it also needs to protect the fetus from maternal immunological attacks while at the same time transmitting maternal immunoglobulins to ensure protection against infectious agents.

It is argued that evolution goes beyond that which can be described in a well-defined language) and that it instead enforces a language that is itself evolving. Evolution is the unfolding of this self-reference. The unfolding methodology of the logician Alfred Tarski is taken as a basis for the explicability of evolution. Looking at Tarski´s results as a linguistic complementarity, we get a view w

The books analyses how the Holocaust has been interpreted, represented and used in various European states and societies from the perpetration of the genocide to the present.

Neoplastic disorders are characterized by recurrent somatically acquired chromosomal aberrations that alter the structure and/or expression of a large number of genes. Most “cancer genes” discovered to date in human neoplasms have been identified through isolation of genes at the breakpoints of balanced chromosomal translocations. Although functional studies of such cancer-causing genes have demon