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This Editorial highlights a study published in the current issue of Journal of Neurochemistry by Dobson et al. (), investigating whether the immunomodulatory agent, laquinimod exerts an immunomodulatory effect on isolated Huntington´s disease monocytes. In Huntington´s disease (HD) a central immune activation is mirrored in the periphery by a low-grade immune response and monocytes isolated from H
Joint cartilage consists of cells embedded in a matrix of fibrous collagen within a concentrated water-proteoglycan gel. The integrity of this matrix is crucial for the biomechanical properties of the joint cartilage. The different components of the matrix are synthesized and degraded by the cartilage cells, a process regulated by the amount of mechanical stress applied to the chondrocytes as well
Traditionally, traffic safety is expressed through the number of accidents (crashes) or people injured, since these are the most direct manifestations of an unsafe traffic environment. As we discuss in this chapter, such an approach has its limitations due to the low frequency of accidents and some other issues. Neither is it unusual that accident data is not available, not reliable or lacks impor
Recent years has seen a number of music researchers taking interest in the concept of affordances. Although interpretation of the concept varies, a common denominator is that affordances are opportunities for actions emerging between a subject and the environment. As such, it is an analytical perspective that highlights material and embodied dynamics of musical practice, dimensions central to musi
This article revisits the Aceh Chinese experience during the 2004 tsunami and their lives in Aceh, shaped by the region’s distinct legal and political context. Drawing on ethnographic research, it follows the life of an Aceh Chinese woman born in a small town south of Banda Aceh, highlighting the tragedy she and her community endured during the Tsunami. Through her memories, the article takes read
Nationalism has a potent influence on historical memory – and this can skew in unexpected directions.
In this paper, we study rational Collet–Eckmann maps for which the Julia set is not the whole sphere and for which the critical points are recurrent at a slow rate. In families where the orders of the critical points are fixed, we prove that such maps are Lebesgue density points of hyperbolic maps. In particular, if all critical points are simple, these maps are Lebesgue density points of hyperbol
Catalonia, like the rest of Spain, is a homeownership society. The most recent official statistics (2011) state that 74 per cent of the population are homeowners, 20 per cent are tenants and 2 per cent live in social housing. Related to tenure status, the state of housing in Catalonia – the second wealthiest autonomous community in Spain – has undergone noteworthy shifts in the first decades of th
Background and purpose — Radiostereometry (RSA) is the current gold standard for evaluating early implant migration. CT-based migration analysis is a promising method, with fewer handling requirements compared with RSA and no need for implanted bone-markers. We aimed to evaluate agreement between a new artificial intelligence (AI)-based CT-RSA and model-based RSA (MBRSA) in measuring migration of
What constraints and conditions are conducive to the innovation of more advanced watercraft technology? This paper explores this question by modeling ancient voyages in the Channel Island region of southern California. The Chumash and Tongva cultures of this region invented an advanced form of boat, the sewn plank canoe, around 500 CE. This new technology led to a rapid increase in maritime travel
Circular business models are seen by many as an attractive way for companies to develop new business opportunities, while simultaneously addressing growing social and environmental challenges beyond traditional Corporate Social Responsibility (CSR) programmes. The development of such business models requires continuous testing and evaluation, which contrasts with the largely linear and interventio
Feedback controllers are typically applied to computing systems by acting on some quantities ("tunable parameters" in the computer science lexicon, think e.g. of a packet drop rate) in order to attain some goal (e.g., a required bandwidth allocation). In other words, control loops are closed around the computing system, that exposes tunable parameters as control actuators, and allows to measure so
