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To study how mechanical factors influence the spread of cancer and the surrounding extracellular matrix (ECM), it is crucial that cancer cell populations be sorted without labels in relevant subpopulations with respect to mechanical properties. It is also important to confine subpopulations for long-term observation to track changes, in inherent properties of the subpopulations, and on the influen
We show acoustic separation of 7.8 µm from 5 µm fluorescent polystyrene particles at an unprecedented sample flowrate of almost 1000 µL/min.
In 1936, when the Provisional Agreement concerning the Status of Refugees coming from Germany was adopted, the same course was followed: the term refugee covered all persons coming from Germany. The definition of the term refugee was not established by the adoption of the 1967 Refugee Protocol, which created a more or less complete correspondence between the mandate of the UNHCR and treaty law. Fr
Krüppel-like factors (KLFs) are transcription factors with important roles in tissue homeostasis. KLF4 possesses antithrombotic and anti-inflammatory properties. In this issue, Estrada et al. show that endothelial KLF4 prevents complement deposition in glomeruli and in its absence the cell-bound complement regulator CD55 was reduced. The study included endothelial-specific KLF4 knockdown mice that
The normal flora furnishes the host with ecological barriers that prevent pathogen attack while maintaining tissue homeostasis. Urinary tract infections (UTIs) constitute a highly relevant model of microbial adaptation in which some patients infected with Escherichia coil develop acute pyelonephritis, while other patients with bacteriuria exhibit an asymptomatic carrier state similar to bacterial
To probe internal motions in proteins on the 10−8−10−5 s time scale by NMR relaxation, it is necessary to eliminate protein tumbling. Here, we examine to what extent magnetic relaxation dispersion (MRD) experiments on the water 1H resonance report on protein motions in this time window. We also perform a critical test of two physically distinct mechanisms that have been proposed to explain and int
There are many possible definitions of “technology” and I will discuss some of these in this book. However, in this introduction let me use a definition of Svante Lindqvist who defines technology very intuitively as “those activities, directed towards the satisfaction of human wants, which produce change in the material world.” He says also “the distinction between human “wants” and more limited h
This paper describes preliminary results from the test-retest of the NAME 1.0. Four scales were tested: Mobility-related participation frequency; Mobility ease/difficulty; Mobility dependence; Extent of assistance in mobility. The test was conducted in the five Nordic countries. In all 147 mobility device users took part in the study, mean age 60 years (range 19 - 93). Each participant was intervi
Lattice Boltzmann method (LBM) is a method that can be used to capture the detailed activities of the transport processes at microscale. Here LBM is used to model the porous anode for an anode-supported Solid Oxide Fuel Cell (SOFC). The purpose of this study is to investigate the effects of electrochemical reactions on the transport processes by a 3D model at microscale. A porous 3D modeling domai
On death dying and disposal in contemporary Sweden.
