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Human dendritic cells (DCs) are a distinct but heterogeneous lineage of APCs operating as the link between innate and adaptive immune responses, with the function to either maintain,tolerance or trigger immunity. The DC lineage consists of several subpopulations with unique phenotypes; however, their functional characteristics and transcriptional similarities remain largely unknown. To further cha
I detta kapitel beskrivs hur man vid Lunds tekniska högskola organiserar kursvärderingar som en del i ett övergripande arbete med rapporterande utvärdering av kurser. Syftet är att bidra med förståelse för hur olika konkreta problem förknippade med genomförandet av ett system för kursvärdering och utvärdering angripits på Lunds tekniska högskola. kapitlet visar också på hur Lunds tekniska högskola
The complexation between a polyion and an oppositely charged spherical macroion in the framework of the primitive model has been studied by the use of Monte Carlo simulations. The polyion length, linear charge density, and bare persistence length are varied systematically, while the properties of the macroion are kept constant. The polyion charge to macroion charge ratio is varied between 1/4 and
The complement system is old, yet it may still have something new to teach us. For many years, research has existed which shows that C3d, in addition to its established role as an adjuvant, could have an immunosuppressive activity. Being true, it suggests that a common mechanism may be used both by organisms and by their pathogens to prevent unwanted immune responses.
Dimethyldodecylamine-N-oxide (DDAO) has only one polar atom that is able to interact with water. Still, this surfactant shows very hydrophilic properties: in mixtures with water, it forms normal liquid crystalline phases and micelles. Moreover, there is data in the literature indicating that the hydration of this surfactant is driven by enthalpy while other studies show that hydration of surfactan
Model systems of cross-linked polyelectrolyte gels were investigated by means of Monte Carlo simulations. The model contained a charged defect-free th ee-dimensional network of a diamond-like topology and explicit counterions. Pressure vs volume relations and chain extensions were determined and compared to those of the corresponding polyelectrolyte solution. The structure of the gel was character
This paper examines lip and jaw kinematics in the production of labial stop and fricative consonants where the duration of the oral closure/constriction is varied for linguistic purposes. The subjects were speakers of Japanese and Swedish, two languages that have a contrast between short and long consonants. Lip and jaw movements were recorded using a magnetometer system. Based on earlier work sho
En förutsättning för insjuknande i cervixcancer är en infektion med genitalt papillomvirus - HPV. Sjukdomen uppstår efter åratal av förstadier, som kan upptäckas genom cervixcytologi/gynekologisk cellprovstagning och stoppas med behandling. I Sverige har cellprovstagningen minskat förekomsten av livmoderhalscancer med 50 procent. I Finland, där man använder organiserad screening, har förekomsten
The capacity of murine liver dendritic cells (DC) to present bacterial Ags and produce cytokines after encounter with Salmonella was studied. Freshly isolated, nonparenchymal liver CD11c(+) cells had heterogeneous expression of MHC class II and CD11b and a low level of CD40 and CD86 expression. Characterization of liver DC subsets revealed that CD8alpha(-)CD4(-) double negative cells constituted t
In the present study we demonstrate that all CD4+ T cells in human tonsil expressing the Th2-selective receptor chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) also 1) express high levels of CXCR5, and 2) display a transitional CD45RA/RO phenotype and consistently do not produce significant amounts of cytokines when immediately analyzed ex vivo. Hence, they represent pr
Stopped-flow fluorescence studies were performed to investigate the kinetics of formation of complexes between DNA and cationic vesicles. We followed the kinetics as a function of charge ratio and lipid vesicle composition. Binary mixtures of a saturated cationic lipid, dioctadecyldimethlammonium bromide (DODAB), and a zwitterionic lipid, dioleoylphosphatidylethanolamine (DOPE), were used to prepa
Cetyltrimethylammonium surfactants with a range of oligo carboxylate anions bearing. 2, 3, or 4 negative charges have been synthesized, and their respective behaviors in binary mixtures with water and in ternary mixtures with added decanol have been investigated. In binary mixtures with water, all surfactants formed nearly spherical micelles at high water contents; however, the interactions betwee
The formation of a capillary phase in segregating mixed polymer solutions confined between two planar walls is modeled by using a lattice mean-field theory for flexible polymers in solution. A capillary-induced phase separation (CIPS) may appear in systems where the two polymer components display different preference for the wall, the preference being either of energetic or entropic origin. A long
An account of the importance of the photographic documentation of the Nazi concentration camps for the reaction to and understanding of Nazism and the Holocaust.
Popular Abstract in Swedish Parkinsons sjukdom är den näst mest vanliga neurodegenerativa sjukdomen och den drabbar 2% av befolkningen över 65 år. Sjukdomen kännetecknas av en gradvis ökad förlust av dopaminproducerande nervceller. Symtomen tilltar successivt och leder framförallt till allvarliga fördröjningar i rörelsemönstret. Dessvärre, när de första symptomen väl upptäcks, så har redan 50% av Parkinson's disease (PD) is the second most common neurodegenerative disease and affects 2% of the population over 65 years of age. The disease is characterized by the progressive loss of dopaminergic neurons. Over time, symptoms increase and, in particular, lead to a dramatic slowness of movements. Unfortunately, when the fi rst symptoms are discovered, more than 50% of the dopaminergic neurons a
To gain further insight into the synthesis and structure of the synovial matrix of joints, we have established cell cultures from synovial specimens and elaborated their production of hyaluronan and proteoglycans. The cultures secreted mainly the small proteoglycan decorin, but also considerable amounts of the related biglycan and the large proteoglycan versican. Only minor amounts of heparan sulf
