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Popular Abstract in Swedish Det finns i Sverige idag över 100 000 personer vilka överlevt insjuknande i stroke (blodpropp eller blödning i hjärnan). Varje år inträffar ca 20 000 ? 25 000 nyinsjuknanden och ca 5 000 - 10 000 återinsjuknanden i stroke. Vanliga symtom både vid det akuta insjuknandet, och senare efter genomgången akutsjukvård och rehabilite-ring, är förlamningar, talrubbningar, sväljnThe aims were to follow stroke patients over time with respect to general pain, shoulder pain, weight loss, and health related quality of life (HRQOL), the latter also in stroke survivors' informal caregivers. Methods During a 1 year period, 416 first-ever stroke patients were included in the population based Lund Stroke Register; 327 survivors were followed up after four months and 305 one year

Lanthipeptides are ribosomally synthesized and post-translationally modified polycyclic peptides. Lanthipeptides that have antimicrobial activity are known as lantibiotics. Accordingly, the discovery of novel lantibiotics constitutes a possible solution for the problem of antibiotic resistance. We utilized the publicly available genome sequences and the bioinformatic tools tailored for the detecti

HAMLET (human alpha-lactalbumin made lethal to tumor cells) is a tumoricidal complex consisting of partially unfolded protein and fatty acid, and was first identified in casein fractions of human breast milk. The complex can be produced from its pure components through a modified chromatographic procedure where pre-applied oleic acid binds with partially-unfolded alpha-lactalbumin on the stationar

Medellivslängden ökar och är idag över 80 år i 34 av världens länder, jämfört med i 19 länder år 2005. Detta ärpositivt, men den åldrande befolkningens hälsa är också en samhällsutmaning inte minst för välfärdssystemen.Hälso- och sjukvården riskerar blir särskilt belastad med allt fler vårdsökande äldre. Yrkesgrupperna inom hälsoochsjukvården har dessutom en hög medelålder och är samtidigt bland d

Solvents are commonly used in pharmaceutical and cosmetic formulations and sanitary products and cleansers. The uptake of solvent into the skin may change the molecular organization of skin lipids and proteins, which may in turn alter the protective skin barrier function. We herein examine the molecular effects of 10 different solvents on the outermost layer of skin, the stratum corneum (SC), usin

Background: Mild induced hypothermia (MIH) was introduced for post cardiac arrest care in Sweden in 2003, based on two clinical trials. This retrospective study evaluated its association with 30-day survival after out-of-hospital cardiac arrest (OHCA) in a Swedish community from 2003 to 2015. Methods: Out of 3680 patients with OHCA, 1100 were hospitalized after return of spontaneous circulation an

Insulin-independent diabetes mellitus is often accompanied by manifestations of autoimmunity and is frequently associated with certain HLA haplotypes, predominantly DR3 and DR4. Because the major histocompatibility antigens are important determinants of the immune response in various tissues, we have investigated their expression on the pancreatic islet cells. Human, mouse, or rat islets of Langer

The role of auditory feedback in vocal production has mainly been investigated by altered auditory feedback (AAF) in real time. In response, speakers compensate by shifting their speech output in the opposite direction. Current theory suggests this is caused by a mismatch between expected and observed feedback. A methodological issue is the difficulty to fully isolate the speaker’s hearing so that

How did human symbolic behavior evolve? Dating up to about 100,000 y ago, the engraved ochre and ostrich eggshell fragments from the South African Blombos Cave and Diepkloof Rock Shelter provide a unique window into presumed early symbolic traditions of Homo sapiens and how they evolved over a period of more than 30,000 y. Using the engravings as stimuli, we report five experiments which suggest t

Uppsatsens syfte har varit att kritiskt granska den svenska debatten kring DNA-analys för asylsökande barns rätt till familjeåterförening i Sverige och därmed se ifall principen om barnets bästa, definierat i svenska rättsakter, efterföljs. Genom den vägledande domen från Migrationsöverdomstolen den 18 januari 2012 fastslogs att DNA-analys kan användas för att styrka biologiskt släktskap med förälThe aim of this thesis has been to do a critical review on the Swedish debate concerning the use of DNA-tests to secure the rights of asylum-seeking children to be reunited with their families and if the principle of the best interests of the child is followed. The 18th of January 2012, in a precedent ruling, the Swedish Migration Court of Appeal concluded that DNA-test could be used to prove biol

The attitude of teachers towards students can vary substantially in relation to different factors, such as educational background, pedagogical training, teaching methods, etc. In this paper, we explore the impact of negative role-models on future teaching. In particular, past experiences of teachers as students as well as the contextual influence of other teachers on their future teaching has been

Emerging evidence suggests differential effects of therapeutic antibiotics on infant T cell responses to pathogens. In this study, we explored the impact of the treatment of mouse infants with amoxicillin and the human milk-derived antimicrobial HAMLET (human alpha-lactalbumin made lethal to tumor cells) on T cell responses to Streptococcus pneumoniae. Lung cells and splenocytes were isolated fr

It is now established that native language affects one's perception of the world. However, it is unknown whether this effect is merely driven by conscious, language-based evaluation of the environment or whether it reflects fundamental differences in perceptual processing between individuals speaking different languages. Using brain potentials, we demonstrate that the existence in Greek of 2 color

In the 1880s, the Anglo-German feminist freethinker Mathilde Blind wrote a series of poems inspired by her residence in Manchester. Our chapter reads Blind’s Manchester poems through the lens of the atmospheric humanities, focusing on how these poems show the entanglement of the human with both urban and natural environments, gesture towards an imagined future for those marginalized in industrial

Vid tiden för Göteborgs 400-årsjubileum var ordet trygghet på många av göteborgarnas läppar. Göteborgs Stad hade sedan några år inlett ett tydligt fokus på att försöka öka invånarnas trygghet genom projekt som ”Trygg i Göteborg” och genom polisiära insatser för att minska den organiserade brottsligheten. Med tanke på sådana insatser tedde det sig kanske inte underligt att hela 15 procent av de sva

We report the use of multinodal acoustic trapping for high throughput and high capacity capturing of EV's (extracellular vesicles) for quantitative mass spectrometry analysis. The multinode trapping unit was shown to isolate sufficient amount of EV's from dilute biological samples (urine and cell culture supernatant) at flow rates of 500 ul/min within minutes, enabling EV proteome profiling. This

Cells of the exocrine pancreas produce digestive enzymes potentially harmful to the intestinal mucosa. Dopamine has been reported to protect against mucosal injury. In looking for the source of dopamine in the small intestine, we found that the duodenal juice contains high levels of dopamine and that the pancreas itself has a high dopamine [and dihydroxyphenylalanine (dopa)] content that does not