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We are developing a prototype system for simultaneous digital breast tomosynthesis (DBT) and mechanical imaging (MI). MI maps the local pressure distribution during clinical exams, to distinguish breast abnormalities from the normal tissue. Both DBT alone, and MI when combined with digital mammography, have demonstrated the ability to reduce false positives; however, the benefit of combining DBT w
We have estimated affinities for the binding of 34 ligands to trypsin and nine guest molecules to three different hosts in the SAMPL3 blind challenge, using the MM/PBSA, MM/GBSA, LIE, continuum LIE, and Glide score methods. For the trypsin challenge, none of the methods were able to accurately predict the experimental results. For the MM/GB(PB)SA and LIE methods, the rankings were essentially rand
This work studies the design of linear precoder codebooks for N-r x N-t MIMO channels with MMSE detection at the receiver. A natural split of precoder-design is unitary precoding and non-unitary precoding. Unitary precoding is only performing rotation of the data in a way beneficial for the channel. Non-unitary precoding additionally also uses power-loading to further improve the performance. Some
The closely related receptor tyrosine kinases c-Kit and Flt3 are mainly expressed in hematopoietic cells and are involved in driving cell proliferation and promoting survival in response to growth factor stimulation. Several gain-of-function mutations of both c-Kit and Flt3 have been found in malignancies like acute myeloid leukemia, gastrointestinal stroma tumors and small cell lung carcinomas, a
Smoking has recently been recognised as causally associated with the development of gastric cancer (GC). However, evidence on the effect by sex, duration and intensity of smoking, anatomic subsite and cessation of smoking is limited. Our objective was to assess the relation between tobacco use and GC incidence in the European Prospective Investigation into Cancer and Nutrition (EPIC). We studied d
Isolated skeletal elements of three hesperornithiform taxa are recorded from marine strata of latest early Campanian (sensu germanico) age in the Kristianstad Basin, southern Sweden. The material comprises Hesperornis rossicus Nessov and Yarkov, one of the largest Mesozoic aquatic birds known to date, Hesperornis sp. and Baptornis sp. The holotype (a dorsal vertebra) of Parascaniornis stensioei La
Hypertensive disorders of pregnancy, including preeclampsia, are major contributors to maternal morbidity. The goal of this study was to evaluate the potential of metabolomics to predict preeclampsia and gestational hypertension from urine and serum samples in early pregnancy, and elucidate the metabolic changes related to the diseases. Metabolic profiles were obtained by nuclear magnetic resonanc
The principle of extended producer responsibility (EPR) has been a policy paradigm behind the development of waste policies in the European Union including the End-of-Life Vehicle (ELV) Directive (2000/53/EC). This study compares and explains the environmental effectiveness of the ELV programmes in the United Kingdom and in Sweden between 1990 and 2005, using a framework that integrates the Dutch
Objective The complex genetic aetiology underlying irritable bowel syndrome (IBS) needs to be assessed in large-scale genetic studies. Two independent IBS cohorts were genotyped to assess whether genetic variability in immune, neuronal and barrier integrity genes is associated with IBS. Design 384 single nucleotide polymorphisms (SNPs) covering 270 genes were genotyped in an exploratory cohort (93
The principle aim of the study is to describe, analyze and problemize the ways in which television science documentaries (within a public service context) discursively represent scientific theories, research results and conclusions about the origins of human nature and the causes of human behavior. The study covers 25 programs broadcasted by SVT and UR during a period of four years, 2002-2005, and
This article explores the “question of the animal” in Swedish artist Ann-Sofi Sidén’s project Queen of Mud, executed between 1988 and 2004. Queen of Mud revolves around a naked female creature, smeared from top to toe in wet mud, which interferes in human affairs and challenges thereby common assumptions about the human/animal divide and the human-animal continuum. By reading Queen of Mud over aga
The specific insertion of a divalent metal ion into tetrapyrrole macrocycles is catalyzed by a group of enzymes called chelatases. Distortion of the tetrapyrrole has been proposed to be an important component of the mechanism of metallation. We present the structures of two different inhibitor complexes: (1) N-methylmesoporphyrin (N-MeMP) with the His183Ala variant of Bacillus subtilis ferrochelat
The machinability of two prehardened mould steels, one continuously-cooled and one quenched and tempered, is compared in terms of cutting temperature, cutting force and tool life. Both materials have a hardness of similar to 40 HRC which is a typical hardness for prehardened mould steels. The results of machinability tests are related to mechanical properties and microstructural features, and the
The overall aim of this thesis was to investigate the initial diabetes education process, the impact on children and their parents and parental satisfaction with the care received one and two years subsequent to the child’s diagnosis. In order to seek a deeper understanding for how the diabetes team’s initial education process works from admission to discharge among families with a child newly dia
OBJECTIVE - Stress may play a role in the pathogenesis of the metabolic syndrome. However, the scant evidence available is not population-based, restricting the external validity of the findings. Our aim was to test associations between stressful life events, their accumulation, and the metabolic syndrome in a large population-based cohort. We also tested associations between stress and the indivi
In migraine and other primary headaches there is a strong vascular component. Besides the trigeminovascular components some of the associated symptoms point to the involvement of brain stem regions. The central limb of the trigeminal vascular pathway is its projection to the trigeminal nucleus caudalis (TNC) and to the C1-C2 levels of the spinal cord. The aim of the present study was to demonstrat
Small-scale power plants based on the SOFC-GT (Solid Oxide Fuel Cell-Gas Turbine) system are foreseen for future application such as APU units in flight transportation systems or stationary power production. Although these new systems offer high load flexibility and potentially high efficiency, there are several constraints referring to thermal/mechanical stress of the fuel cell as well as to a po
Last year, we reported a perturbative theory of the Casimir-Lifshitz torque between planar biaxially anisotropic materials in the retarded limit [Thiyam et al., Phys. Rev. Lett. 120, 131601 (201810.1103/PhysRevLett.120.131601)], which is applied here to study the change in sign and magnitude of the torque with separation distance in biaxial black phosphorus having excess charge carriers. The study
