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Germline BRCA1 mutations predispose to breast cancer. To identify genetic modifiers of this risk, we performed a genome-wide association study in 1,193 individuals with BRCA1 mutations who were diagnosed with invasive breast cancer under age 40 and 1,190 BRCA1 carriers without breast cancer diagnosis over age 35. We took forward 96 SNPs for replication in another 5,986 BRCA1 carriers (2,974 indivi
Abstract In childhood atopic dermatitis (AD) is the most frequent inflammatory condition. Validated eczema questionnaires have been available for schoolchildren only, but the incidence of atopic dermatitis is highest during infancy. Evidence is needed on the further development of asthma, and rhinitis in these infants with AD and on remission of AD in children. We aimed to validate a parental ques
This thesis is a study of the articles published in the Chinese newspaper 人民日报 Renmin Ribao, the People’s Daily, during the Great Chinese famine 1959-1961. The famine is considered to be the worst famine in the history of China and an estimated more than 30 million people died of starvation or illnesses brought about by starvation during these years. This thesis will be focusing on the articles pu
This essay studies the Swedish law on dangerous asocial behaviour, lagen om åtgärder mot samhällsfarlig asocialitet (SFS 1964:450). The law was passed during a period of time in Swedish social political history characterized by a growing social state and a greater focus on individual rights than before. The stated purpose of the law was, among other things, to send problematic individuals, asocial
Introduction: Proteomics may help discover novel biomarkers and underlying mechanisms for cardiovascular disease. This could be useful for childhood cancer survivors as they show an increased risk of cardiovascular disease. The aim of this study was to investigate circulating cardiovascular proteins in young adult survivors of childhood cancer and their relationship to previously reported subclini
BACKGROUND: Acute retroviral syndrome (ARS) is associated with HIV-1 subtype and disease progression, but the underlying immunopathological pathways are poorly understood. We aimed to elucidate associations between innate immune responses during hyperacute HIV-1 infection (hAHI) and ARS.METHODS: Plasma samples obtained from volunteers (≥18.0 years) before and during hAHI, defined as HIV-1 antibody
With an increasing demand for rural resources and land, new challenges are approaching affecting and restructuring the European countryside. While creating opportunities for rural living, it has also opened a discussion on rural gentrification risks. The concept of rural gentrification encircles the influx of new residents leading to an economic upgrade of an area making it unaffordable for local
Violence against women is a major public health concern. Comparative research on outcomes across different service providers remains limited. Method: Women seeking support from social welfare units or women's shelters were recruited from six organizations in Sweden. A pre–post design was applied, with structured interviews and questionnaires at baseline and 1-year follow-up. Fifty-one women partic
BACKGROUND: Definition of temporal serum proteome profiles after out-of-hospital cardiac arrest may identify biological processes associated with severe hypoxia-ischaemia and reperfusion. It may further explore intervention effects for new mechanistic insights, identify candidate prognostic protein biomarkers and potential therapeutic targets. This pilot study aimed to investigate serum proteome p
Although thinking double thoughts and living dual lives are not specifically Iranian traits, Iranians have, nevertheless, become more susceptible to them for historical reasons, which may be traced back to when Persians became Muslims. The gradual normalization of double‐thinking over the centuries has given rise to social and political patterns of behavior and institutional arrangements which osc
Despite the expanding role of services in the global economy, economic history has paid lit-tle attention to their geographic localization. This paper provides a description of the increasing specialization and localization patterns of services across US counties compared to other sectors from 1930 to 2010. It stresses that market potential influences most of these changes. I use cen-sus employmen
In developing EnergyNet we have leveraged and are extending lessons from telecom's shift from a centralized, circuit-switched phone system to decentralized, packet-switched data networks. EnergyNet utilizes 1) an Energy Router that enforces galvanic separation and utilizes software-controlled energy flows over a DC backplane, 2) Energy Local and Wide Area Networks (ELAN/EWAN) based on DC microgridIn developing EnergyNet we have leveraged and are extending lessons from telecom's shift from a centralized, circuit-switched phone system to decentralized, packet-switched data networks. EnergyNet utilizes 1) an Energy Router that enforces galvanic separation and utilizes software-controlled energy flows over a DC backplane, 2) Energy Local and Wide Area Networks (ELAN/EWAN) based on DC microgrid
This masters thesis deals with smoke spread via ventilation systems. One aim of the thesis is to investigate and explain the differences in efforts to prevent smoke spread via ventilation systems in different countries. A second aim of this thesis is to investigate how frequently occurring smoke spread via ventilation systems in Swedish buildings are. A third aim is to investigate how uncertaintie
BackgroundViolence is a major public health concern with a significant impact on the health and well-being of individuals, families, and communities. Living in a new environment without parental control and experimenting with new lifestyles may increase the risk of violence among university students. Therefore, this study aimed to assess exposure to violence and its associated factors among univer
