Search results

Background: Some patients with atrial fibrillation (AF) cannot be treated with vitamin K antagonists (VKAs) and will therefore not receive effective thromboprophylaxis. The primary objective of the present Phase II trial (NCT00623779) was to assess the feasibility of conducting a study with a novel oral anticoagulant, the direct thrombin inhibitor AZD0837, in patients with AF unable or unwilling t

By employing seven semi-structured interviews with local judges and prosecutors in Kosovo, this study aims at examining how the European Union Rule of Law Mission (EULEX) has impacted the legal order in Kosovo and the practice of the judges and prosecutors. In addition, this study examines how the impacts of EULEX, and how the judges and prosecutors will be affected after the EULEX are withdrawn f

Given the calls to examine accelerators across different regions and contexts, we ask the research question: How do accelerators adapt to institutional, social, and spatial constraints of emerging and established ecosystems? With this research question, we conduct qualitative research to understand how two different accelerators, one located in Skåne, Sweden and another located in Dhaka, Banglades

Evidence of air pollution exposure, namely, ambient particulate matter (PM), during pregnancy and an increased risk of autism in children is growing; however, the unique PM sources that contribute to this association are currently unknown. The aim of the present study was to investigate local, source-specific ambient PM exposure during pregnancy and its associations with childhood autism, specific

BACKGROUND: Tuberculosis remains a leading infectious cause of death in resource-limited settings. Effective treatment is the cornerstone of tuberculosis control, reducing mortality, recurrence and transmission. Supporting treatment adherence through facility-based observations of medication taking can be costly to providers and patients. Digital adherence technologies (DATs) may facilitate treatm

Collagen VII is an essential anchoring protein in the basement membrane zone, maintaining the attachment of stratified and pseudostratified epithelia to the underlying interstitial matrix. However, collagen VII is largely unexplored in normal lungs and idiopathic pulmonary fibrosis (IPF), a disease characterized by excessive accumulation of extracellular matrix (ECM) and aberrant re-epithelializat

High latitude mires are key ecosystems in the context of climate change since they store large amounts of carbon while constituting an important natural source of methane (CH4). However, while a growing number of studies have investigated methane fluxes (FCH4) at the plot- (~1 m2) and ecosystem-scale (~0.1–0.5 km2) across the boreal biome, variations of FCH4 magnitudes and drivers at the mesoscale

The future role of boreal forests in the global carbon cycle is uncertain given the rapid climate change in high latitudes. At the landscape scale, heterogeneity in stand age and land cover, contributions from terrestrial and aquatic fluxes, and harvest export may create complex carbon cycle-climate interactions. However, the integrated response of the net landscape carbon balance (NLCB) to inter-

Deposition of phosphorus (P) is important for the nutrient supply to forests and open land but also contributes to the eutrophication of surface waters. Deposition to open land can be measured as bulk deposition while deposition to forests cannot be measured directly, due to internal circulation of P within forest canopies. This study aimed to quantify the total deposition of P to open land and fo

Väpnade aktörer, terrorism och illegal handel (med människor, narkotika och vapen) är alla företeelser som, i varierande omfattning, florerar i fallerade stater. Dessa företeelser återfinns inte minst i Colombia, som trots det inte bedöms vara fallerad. Uppsatsens syfte är att påvisa behovet av kvalitativa och kontextspecifika studier, då vår förförståelse är att analyser av fallerade stater, som

Previous studies suggest an increased risk of new-onset type 2 diabetes (T2D) following SARS-CoV-2 infection, which may be subject to detection bias from increased health care contacts among the infected. We aimed to assess the causal effect of SARS-CoV-2 infection on new-onset T2D using a test-negative design and negative control outcomes. We included all individuals aged ≥ 18 years registered in

In the adult murine brain, neural stem cells (NSCs) can be found in two main niches: the dentate gyrus (DG) and the subventricular zone (SVZ). In the DG, NSCs produce intermediate progenitors (IPs) that differentiate into excitatory neurons, while progenitors in the SVZ migrate to the olfactory bulb (OB), where they mainly differentiate into inhibitory interneurons. Neurogenesis, the process of ge

Firefighters can be occupationally exposed to a wide range of airborne pollutants during fire-extinguishing operations. The overall study aim was to characterize occupational exposure to smoke for several groups of workers responding to fires, with specific aims to determine the correlations between exposure markers and to biologically assess their systemic exposure to polycyclic aromatic hydrocar

Ageing societies are facing major housing challenges. Understanding and addressing older adults' diverse housing needs and preferences are crucial. Having access to suitable and sustainable housing options can improve social cohesion, independence, health, and well-being. Participatory processes in housing development can enhance inclusion and democratic participation. This study uses Ramlösa Port

Many forms of bioimage analysis involve the detection of objects and their outlines. In the context of microscopy-based high-throughput drug and genomic screening and even in smaller scale microscopy experiments, the objects that most often need to be detected are cells. In order to develop and benchmark algorithms and neural networks that can perform this task, high-quality datasets with annotate

The immune cell component of the tumor microenvironment is an important modulator of tumor progression. In patients with breast cancer, tumor-infiltrating lymphocytes (TILs) and tertiary lymphoid structures (TLS) represent core aspects of anti-tumor immunity, both increasingly recognized for clinical relevance. In this study, we evaluated immune-related histology features using whole slide H&E