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BackgroundPopulations of long-distance migratory birds experience different environments and are consequently exposed to different parasites throughout their annual cycles. Though, specific whereabouts and accompanied host-parasite interactions remain unknown for most migratory passerines. Collared sand martins (Riparia riparia) breeding in the western Palaearctic spend the nonbreeding period in A
Background: This study investigates the patterns of PET-positive lymph nodes (LNs) in anal cancer. The aim was to provide information that could inform future anal cancer radiotherapy contouring guidelines. Methods: The baseline [18F]-FDG PET-CTs of 190 consecutive anal cancer patients were retrospectively assessed. LNs with a Deauville score (DS) of ≥3 were defined as PET-positive. Each PET-posit
The SRY (sex determining region Y)-box 11 (SOX11) gene, located on chromosome 2p25, encodes for a transcription factor that is involved in tissue remodeling during embryogenesis and is crucial for neurogenesis. The role for SOX11 in hematopoiesis has not yet been defined. Two genes under direct control of SOX11 are the class- III β-tubulin gene (TUBB3) in neural cells and the transcription factor
Even though floral scent is of major importance for pollinator attraction, it is less investigated than other floral traits. Previous studies suggest the importance of joint exploration of olfactory and visual floral cues to understand plant–pollinator interactions. We investigated flower scents in Collinsia heterophylla, a bee-pollinated, annual herb a with mixed-mating system combining self- and
Objective The current study aimed to check whether early vascular aging, measured as carotid-femoral pulse wave velocity (cfPWV), is related to kidney function, measured as creatinine-based estimated glomerular filtration (eGFR) and urinary albumin-to-creatinine ratio (UACR), in middle-aged subjects with metabolic syndrome. Methods Participants were recruited from Lithuanian high-risk cohort (LitH
PURPOSE: The incidence of colorectal cancer (CRC) is increasing in individuals aged < 50 years of age. This study aimed to examine whether high-frequency follow-up after CRC surgery reduces 5-year overall mortality, cancer-specific mortality and recurrence in patients with CRC aged ≤ 50 years. METHODS: The COLOFOL trial performed between 2006 and 2010 was used to analyse patients randomised to hig
Objective: Worse women's outcomes after elective standard endovascular aneurysm repair have been widely reported. Similar data have surfaced from cohorts undergoing fenestrated and branched repair; however, studies reporting from a sex perspective are rare and mostly limited to single centre designs. This study aimed to examine survival following nationwide complex endovascular repair according to
Objective: To characterize patients with protein-losing enteropathy (PLE) diagnosed before age 18 years within a nationwide Swedish Fontan cohort. Methods: Surgical records and medical charts were reviewed for all patients born after January 1, 1993, who underwent Fontan completion before January 1, 2021. Results: Among 573 reviewed patients, 28 (4.8%) developed PLE. The median time to onset of PL
BACKGROUND In patients with acute myocardial infarction (MI), therapies that could further reduce the risk of adverse cardiovascular and metabolic outcomes are needed. METHODS In this international registry-based, randomized, double-blind trial, patients without prior diabetes or chronic heart failure, presenting with acute MI and impaired left ventricular systolic function, were randomly assigned
Purpose: Reduced rapid-eye movement (REM) sleep has been linked to increased mortality in the general population. We investigated whether diminished REM sleep is associated with higher mortality in adults with coronary artery disease (CAD) and obstructive sleep apnea (OSA). Methods: This secondary analysis of the RICCADSA trial included 356 revascularized CAD patients with OSA (apnea–hypopnea inde
Background: Helicobacter pylori (Hp) and its virulence factor Cytotoxin-associated gene A (CagA) have been linked to myocardial infarction (MI), but the mechanisms are unknown. This study aims to test if Hp infection and CagA are associated with pre-specified inflammatory and vascular biomarkers in patients with MI and to explore whether a broader biomarker panel can predict infection. Furthermore
Urban meteorology, the study of atmospheric phenomena in urban areas, is vital for understanding the dynamic interactions between rapid urbanization and environmental changes. Over the past two decades (2004–2024), urban heat islands (UHIs), extreme rainfall, pollution, and temperature anomalies have intensified, adversely affecting human health, infrastructure, and ecosystems worldwide. The prese
Abstract – Introduction: – Spinal disorders are among the biggest contributors to health care utilization (HCU).Objective: – To develop and externally validate a prediction model for high all-cause HCU (75th percentile during 1 year after the index date) among patients with spinal disorders visiting multidisciplinary secondary care clinics.Methods: – We developed and internally validated the model
Background Carotid and coronary atherosclerosis are critical determinants of cardiovascular risk, yet their interrelationship in middle-aged populations is incompletely understood. This study assessed carotid plaque composition, risk-factor associations, coronary disease, and sex differences in a subclinical cohort. Methods Within the Swedish CArdioPulmonary bioImage Study, 533 asymptomatic indivi
Background: Tick-borne encephalitis (TBE) is a serious vector-borne neurological disease in Europe, with a complex transmission cycle involving ticks of genus Ixodes, animal hosts, environmental and climatic determinants. Methods: We modelled annual Geocoded Swedish TBE case data for the period 2005–2023 as a log-Gaussian Cox process in relation to population, environmental and climate data, and w
Background: Quantitative fecal immunochemical test (FIT) is widely used for colorectal cancer (CRC) screening, with substantial variation in positivity thresholds across countries. This study examines how these thresholds affect FIT's diagnostic performance for detecting CRC and advanced precancerous lesions (APCL). Methods: We analyzed data from a single round screening of 7398 men and women aged
Background: Physical inactivity is a main cause of childhood obesity which tracks into adulthood obesity, making it important to address early in life. Physical activity on prescription (PAP) is an evidence-based intervention that has shown good effect on physical activity levels in adults, but has not been evaluated in children with obesity. This project aims to evaluate the prerequisites, determ
BACKGROUND: Triglyceride-glucose (TyG) index is a useful low-cost marker of insulin resistance. We aimed to evaluate the association between TyG index and arterial stiffness, incidence of diabetes, adverse cardiovascular outcomes, and all-cause and cardiovascular mortality in two large prospective Swedish cohorts, the Malmö Diet and Cancer Study-Cardiovascular Cohort (MDCS-CV) and the Malmö Preven
Aim: Understanding how climate conditions influence plant–pollinator interactions at the global scale is crucial to understand how pollinator communities and ecosystem function respond to environmental change. Here, we investigate whether climate drives differences in network roles of the main insect pollinator orders: Diptera, Coleoptera, Lepidoptera and Hymenoptera. Location: Global. Time period
The EU Biodiversity strategy aims to plant 3 billion trees by 2030, in order to improve ecosystem restoration and biodiversity. Here, we compute the land area that would be required to support this number of newly planted trees by taking account of different tree species and planting regimes across the EU member states. We find that 3 billion trees would require a total land area of between 0.81 a
