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PURPOSE OF REVIEW: Small cell lung cancer (SCLC) is an aggressive disease with a poor prognosis, whereas its metastatic capacity carries a predilection for the brain. Although prophylactic cranial irradiation (PCI) has been used to address this problem, upcoming alternatives might necessitate reflection of its application in SCLC treatment. RECENT FINDINGS: The addition of immunotherapy to treatme
Purpose: To remedy the lack of a measure that jointly assesses the psychological status and impact of migration stressors among forced migrants, we developed and tested the Screening of Refugees Self-Report (ScoRE-SR) Questionnaire.Method: Four institutions with expertise on posttraumatic symptomatology and/or migration stressors developed the ScoRE-SR through an iterative process also involving c
This paper explores how pro-active government policies could promote artificial intelligence (AI) in healthcare for the public good. Building on insights from the literature on industrial policy, we argue that without clear conditions and guardrails to ensure future public benefit, state assistance and subsidies will be nothing more than corporate welfare with unpredictable, if any, societal benef
In pursuit of advancing the capabilities of ground testing facilities, a complete road map for broadening operational range of the H3 hypersonic blowdown wind tunnel, operated at the von Karman Institute for Fluid Dynamics (VKI), with the addition of a new Mach 5 contoured nozzle is constructed. The main characteristics of the facility are presented. The supersonic ejector is identified as a criti
This CMES Regional Outlook by Pinar Dinc focuses on the recent political developments in Turkey.
Due to the large amount of accidents negatively affecting the wellbeing of the survivors and their families, a substantial amount of research is conducted to determine the causes of road accidents. This type of data come in the form of non-negative integers and may be modelled using the Poisson regression model. Unfortunately, the commonly used maximum likelihood estimator is unstable when the exp
In recent years, a growing interest in sustainable tourism and outdoor recreation has emerged in Sweden and globally. While a positive development for many reasons, it coincides with other shifting patterns in recreational nature use, influenced by climate change, social media, and experimental interventions in natural areas. These developments bring opportunities to broaden participation, but als
Atrial fibrillation and heart failure have both been suggested to increase stroke and dementia risk. However, in observational studies, reversed causation and unmeasured confounding may occur. To mitigate these issues, this study aims to investigate if higher genetic risk for atrial fibrillation and heart failure increases dementia and stroke risk. Data were obtained from the population-based Goth
Debate over the future of international science takes place in light of two trends that are frequently interpreted as standing in tension with each other. The longer-term pattern shows that science is increasingly an international endeavour, as collaboration across borders has grown. A more recent apparent re-nationalisation of science, however, raises questions over the march of international sci
The purpose of this work is to identify and analyze the key important barriers to uptake the compressed biogas (CBG) plants in India for enhancing their role as a sustainable energy source. Initially, the barriers are identified from the past academic literature using literature review process and are then validated through the fuzzy Delphi method with expert opinions. The finalized barriers were
The legal opacity of AI technologies has long posed challenges in addressing algorithmic harms, as secrecy enables companies to retain competitive advantages while limiting public scrutiny. In response, ideas such as qualified transparency have been proposed to provide AI accountability within the confidentiality constraints. With the introduction of the EU AI Act, the foundations for human-centri
A crystallogenesis study of human transthyretin using the counter-diffusion method is described as an alternative to conventional convective vapour diffusion and batch approaches for protein crystallization. The X-ray diffraction results show systematic trends that exhibit unique patterns of crystallization and high crystal quality as well as a remarkable degree of coherence within extended crysta
INTRODUCTION: Behavioral and psychological symptoms of dementia (BPSD) are a common driver of suffering and high care needs. We describe the Swedish BPSD registry, founded in 2010 to develop an evidence base for quality improvement in the care of patients with BPSD. Further, we illustrate the potential of the registry by evaluating how individual BPSD affects mortality. METHODS: The registry provi
Improving accuracy and timeliness for osteoporosis diagnosis could help prevent fragility fractures, morbidity, and mortality for older individuals. Osteoporosis is an often silent health condition, especially as regards vertebral fractures, and WHO issued a call to action for primary care to lead efforts in screening, assessing, and managing diseases such as osteoporosis. We used a machine learni
Empiric combination antibiotic therapy (ECAT) is commonly used to treat healthcare-associated bloodstream infections (HA-BSIs) and sepsis. However, the level of supporting evidence is low and clinical practice varies significantly. We conducted a post hoc analysis using the EUROBACT-2 international cohort study database, which contained data on 2406 adult patients from 328 intensive care units (IC
Böcker och läsning är ett centralt motiv i berättelsen om Jane Eyre (1847), vilket på många sätt bidrar till framställningen av karaktärisering, världsbygge och narrativets framfart. Det finns särskilt samband mellan framställningen av böcker och läsning och framställningen av makt och maktdynamiker i Jane Eyre. Tidigare forskning om böcker och läsepraktiker i Jane Eyre har fokuserat på den allusiBooks and reading are a central motif within the narrative of Jane Eyre (1847) by Charlotte Brontë and contributes in many ways to the depiction of characterisation, world-building, and the progression of the narrative. In particular, there are correlations between the depiction of books and reading and the depiction of power and power dynamics in Jane Eyre. Previous research into books and readin
Major depressive disorder (MDD) is a prevalent psychiatric condition and poses a significant burden on public health. The underlying causes and mechanisms of depression remain poorly understood. There is a growing body of evidence linking microRNAs (miRNAs) to major depressive disorder (MDD). However, the causal relationship between miRNAs and MDD remains unclear. This study aimed to investigate t
The Iberian Lynx (Lynx pardinus) faces imminent endangerment due to climate change resulting in the declining population of its primary prey, the European Rabbit (Oryctolagus cuniculus). With ongoing environmental shifts, this threat intensifies, heightening the risk of extinction for the species. The aim of this study was to explore a potential conservation strategy; the possibility of relocating
