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IMPORTANCE: Behavior therapy is a recommended intervention for Tourette syndrome (TS) and chronic tic disorder (CTD), but availability is limited and long-term effects are uncertain.OBJECTIVE: To investigate the long-term efficacy and cost-effectiveness of therapist-supported, internet-delivered exposure and response prevention (ERP) vs psychoeducation for youths with TS or CTD.DESIGN, SETTING, AN
In this essay I argue that with too few alternative approaches, the strong feminist epistemological habit of attending to the political utility of art risks placing representations of subjective narratives whose emancipatory qualities might be unclear or doubtful out of scholarly reach. Feminist art historian Irit Rogoff discusses how feminist art historians are inclined to acknowledge visual repr
To stay competitive in today’s environment, characterized by changing customer requirements, digitalization, new technologies, etc., companies must deliver fast and continuous innovation. Manufacturing companies have therefore started to launch large-scale agile transformation initiatives. A specificity of manufacturing companies is their need for deeply specialized organizational units. Knowledge
This article analyses the claims of contemporary disabilityrights activists mobilising in a context where de facto second-class citizenship co-exists with legal and political declarationsabout the rights of disabled people. As an empirical case,it focuses on the blog ‘Full Participation.Now’, which wasinitiated by disability rights activists in Sweden. Drawing uponcitizenship research, the article
Weighted blankets are a non-pharmacological intervention for treating sleep and anxiety problems in children with attention-deficit/hyperactivity disorder. However, research on the efficacy of weighted blankets is sparse. The aim of this randomized controlled trial with a crossover design (4 + 4 weeks) was to evaluate the efficacy of weighted blankets on sleep among children with attention-deficit
Introduction Firefighters have increased risk of chronic respiratory disease. Standard clinical techniques used in medical checkups may not detect the earliest microstructural changes in peripheral airways. A new technique called Airspace Dimension Assessment (AiDA) has been shown to enable early detection of emphysema in COPD. This method may be useful in the occupational setting to detect early
The Rieger syndrome is an autosomal dominant disease characterized by ocular, craniofacial, and umbilical defects. Patients have mutations in PITX2, a paired-bicoid homeobox gene, also involved in left/right polarity determination. In this study we have identified a family of genes for enzymes responsible for hydroxylizing lysines in collagens as one group of likely cognate targets of PITX2 transc
Over the past decade, there has been increasing interest in the use of grounded theory in information systems research. Grounded theory is a qualitative research method that seeks to develop theory that is grounded in data systematically gathered and analysed. The purpose of this paper is to suggest guidelines for grounded theory studies in information systems. Our guidelines are based on a framew
N-acyl taurines (NATs) are bioactive lipids with emerging roles in glucose homeostasis and lipid metabolism. The acyl chains of hepatic and biliary NATs are enriched in polyunsaturated fatty acids (PUFAs). Dietary supplementation with a class of PUFAs, the omega-3 fatty acids, increases their cognate NATs in mice and humans. However, the synthesis pathway of the PUFA-containing NATs remains undisc
The transition to agile manufacturing, Industry 4.0, and high-mix-low-volume tasks require robot programming solutions that are flexible. However, most deployed robot solutions are still statically programmed and use stiff position control, which limit their usefulness. In this paper, we show how a single robot skill that utilizes knowledge representation, task planning, and automatic selection of
INTRODUCTION: Platelet transfusions are frequently used in intensive care unit (ICU) patients, but contemporary epidemiological data are sparse. We aim to present contemporary international data on the use of platelet transfusions in adult ICU patients with thrombocytopenia.METHODS: This is a protocol and statistical analysis plan for a post hoc sub-study of 504 thrombocytopenic patients from the
We introduce a model description of a diatomic molecule in an optical cavity, with pump and fluorescent fields, and electron and nuclear motion are treated on equal footing and exactly. The model accounts for several optical response temporal scenarios: A Mollow spectrum hindered by electron correlations, a competition of harmonic generation and molecular dissociation, a dependence of fluorescence
This chapter provides a reassessment of the waste ‘crises’ in the so-called Land of Fires in Italy and highlights the contribution of local social mobilizations in advancing environmental justice and sustainability concerns. It is based on the long term collaboration between a social scientist and two activists, and it draws from a dialogue of academic and activist knowledge in the tradition of En
As an emerging country, Vietnam needs competent business entrepreneurs who are expected to modernize the economy, renew business and management practices, and develop sustainable growth strategies. The mission of business and management education, thus, is to prepare graduate students for the development of transitional Vietnam and future global challenges. Graduates’ competency, according to comp
Secondary mitral regurgitation (MR) occurs despite structurally normal valve apparatus due to an underlying disease of the myocardium leading to disruption of the balance between tethering and closing forces with ensuing failure of leaflet coaptation. In patients with heart failure (HF) and left ventricular dysfunction, secondary MR is independently associated with poor outcome, yet prognostic ben
Many glaciated valleys in Scotland contain distinctive, closely spaced ridges and mounds, which have been termed ‘hummocky moraine’. The ridges and mounds are widely interpreted as ice-marginal moraines, constructed during active retreat of mainly temperate glaciers. However, hummocky terrain can form by various processes in glacial environments, and it may relate to a range of contrasting glaciod
Studying the routes flown by long-distance migratory insects comes with the obvious challenge that the animal’s body size and weight is comparably low. This makes it difficult to attach relatively heavy transmitters to these insects in order to monitor their migratory routes (as has been done for instance in several species of migratory birds. However, the rather delicate anatomy of insects can be
