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Background: We evaluated the efficacy and safety of the aromatase inhibitor exemestane in patients with advanced, persistent or recurrent endometrial carcinoma. Methods: We performed an open-label one-arm, two-stage, phase II study of 25 mg of oral exemestane in 51 patients with advanced (FIGO stage III-IV) or relapsed endometrioid endometrial cancer. Patients were stratified into subsets of estro
The purpose of this phase II randomized trial was to evaluate the effect and safety of interferon-2a (IFN) in combination with extended dosing rituximab in patients with symptomatic, advanced indolent lymphoma responding to a standard single course of rituximab. Totally 123 patients were treated with rituximab 375mg/m2 once weekly for 4 weeks leading to 14 complete response (CR; 11%), 56 partial r
Background: The use of inhaled corticosteroids (ICSs) is associated with an increased risk of pneumonia in patients with COPD. However the risks of other respiratory infections such as TB and influenza remain unclear. Methods: Through a comprehensive literature search of MEDLINE EMBASE CINAHL Cochrane Library and ClinicalTrials.gov from inception to July 2013 we identified randomized controlled tr
Objectives. Studies have suggested a correlation between untreated celiac disease and risk for other autoimmune diseases. We investigated the prevalence of thyroid autoimmunity in 12-year-old children (i) with symptomatic celiac disease diagnosed and treated with a gluten-free diet, (ii) with screening-detected untreated celiac disease, and (iii) without celiac disease. Methods. Blood samples from
This project was done for the company Beijer Electronics Products AB and the task was given by the hardware development department of the company. The project was about developing a concept proposal for a new generation operator panels. This was done to inspire the product developers at Beijer Electronics with innovative ideas before the actual operator panel development. More in detail the object
In one way, international adoptees stands with one foot in each country. Their looks might make them look like they belong on the other side of the globe, but in manners, language, taste of music and interests they may be exactly like ethnical Swedish kids. Many adoptees experience that they don’t get looked at as swedes, because their appearance isn’t typical Swedish. This essay addressing if, an
Under 2015 ansökte 162 877 personer asyl i Sverige. Av dessa asylsökande var 35 369 ensamkommande barn. Detta var en femdubbling jämfört med föregående år. När den som söker asyl är ett barn har denne fler rättigheter och högre krav ställs på mottagandet. Det ansågs därmed viktigt att skapa en metod för att fastställa huruvida dessa asylsökande verkligen var under 18 år. Rättsmedicinalverket fick In 2015, 162 877 people applied for asylum in Sweden. 35 369 of these asylum seekers were unaccompanied minors. This was a five-fold increase compared to the previous year. When an asylum seeker is an unaccompanied minor he or she should benefit of certain rights, including housing, schooling and potential family unification. It was therefore considered necessary to put in place a medical age asse
Prior to the accomplishment of this research, the compatibility of the classic e-servicescape conceptual model in the context Taobao and TMall in China were rarely found among existing e-servicescape literatures due to the standardization taken by both online platforms towards the establishment of individual webshops. Meanwhile, the conceptualization of social factors as social dimension of e-serv
In E. coli cells ribosomal small subunit biogenesis is regulated by RNA-protein interactions involving protein S7. S7 initiates the subunit assembly interacting with 16S rRNA. During shift-down of rRNA synthesis level, free S7 inhibits self-translation by interacting with 96 nucleotides long specific region of streptomycin (str) mRNA between cistrons S12 and S7 (intercistron). Many bacteria do not
Abstract Objectives: The area of regenerative work is still close to unexplored. The aim was to explore the possibility for employees to gain energy at work. Methods: Questionnaire to all employees (n = 599) from different professions in public and private primary health care centers in one health care district in Sweden. The questionnaire, which had a salutogenic perspective, included information
Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency is commonly seen in malaria endemic areas as it is known to confer a selective advantage against malaria. Recently, we reported a high proportion of asymptomatic reservoir of Plasmodium vivax in Botswana, that calls for intervention with primaquine to achieve radical cure of vivax malaria. Considering that individuals with this enzyme deficiency
X-ray examinations of the pelvis and the urinary tract are frequent examinations of children, in which a large part of the trunk is irradiated. The irradiated volume contains many of the most radiation sensitive organs and tissues. The absorbed dose to children during the examination was estimated from measurements with a dose-area product meter and thermoluminescent dosemeters (TLDs). Entrance su
A crucial chemical link between stars and their orbiting exoplanets is thought to exist. If universal, this connection could affect the formation and evolution of all planets. Therefore, this potential vital link needs testing by characterizing exoplanets around chemically-diverse stars. We present the discovery of two planets orbiting the metal-poor, kinematic thick-disc K-dwarf TOI2345. TOI-2345
Most of the experiments related to quantum information applications, involving rare-earth doped inorganic crystals, are performed on yttrium orthosilicate single crystals. The work presented here is motivated by the search of new compounds which can be used in the field of quantum computing and/or quantum storage. Relaxation times and hyperfine structure of the H-3(4)(0)-> D-1(2)(0) transition in
OBJECTIVE - To elucidate whether family characteristics and stressful life events were associated with onset of autoimmune type 1 diabetes in young adults. RESEARCH DESIGN AND METHODS - This investigation was based on a nation-wide study (Diabetes Incidence Study in Sweden) of newly diagnosed patients aged 15-34 years. Patients clinically classified as type 1 diabetic with antibodies to islet cell
