Filetype
Key topics in the study of host–microbe interactions—such as the prevention of drug resistance and the exploitation of beneficial effects of bacteria—would benefit from concerted efforts with both mechanistic and evolutionary approaches. But due to differences in intellectual traditions, insights gained in one field rarely benefit the other. Here, we develop a conceptual and analytical framework f
BACKGROUND: It is still not clear whether anastomotic leakage after anterior resection for rectal cancer affects long-term functional outcome. OBJECTIVE: This study aimed to evaluate how anastomotic leakage following anterior resection for rectal cancer influences defecatory, urinary, and sexual function. DESIGN: In this retrospective population-based cohort study, patients were identified through
A deprioritization of economic growth in policy making in the rich countries will need to be part of a global effort to re-embed economy and society into planetary boundaries. However, societal support for a degrowth transition remains for the time being moderate, and it is not well understood as yet why this is the case. This article argues that Pierre Bourdieu’s sociology can help theorize socie
Lignin is the second most abundant biopolymer in nature and a promising renewable resource for aromatic chemicals. For the understanding of different lignin isolation and conversion processes, the identification of phenolic compounds is of importance. However, due to the vast number of possible chemical transformations, the prediction of produced phenolic structures is challenging, and a non-targe
During the First World War Muslim soldiers from India made up a significant part of the British forces. Attempts to satisfy the soldiers' religious needs became a British strategy to maintain military discipline among the soldiers in Europe and to avoid public unease and discontent in colonial India. Based on archival material, this article examines how the British tried to identify the religious
Various less-toxic substitutes for the Pb2+-based perovskites have been proposed, of which Sn2+-based metal halide perovskites (namely, Sn-PVSKs) hold the best prospects because of their optoelectronic properties comparable to those of the Pb analogues. Nevertheless, the intrinsic instability and unfavorable crystallization of Sn-PVSKs place restrictions on both the device performance/durability a
This article analyzes administrative practices in relation to the emergence of novel technologies. “Smart mobility” is an umbrella term used to denote the potentially disruptive changes in the transport sector relating to automatization, digitalization, and the platform economy. While this development is largely driven by industry, public administrations are engaging in a number of processes where
Most catalytic, structural and regulatory functions of the cell are carried out by functional modules, typically complexes containing or consisting of proteins. The composition and abundance of these complexes and the quantitative distribution of specific proteins across different modules are therefore of major significance in basic and translational biology. However, detection and quantification
The UN Security Council's involvement in the area of international criminal justice raises concerns about judicial independence. Of primary concern in this study is the degree to which this political organ has come to determine and restrict jurisdiction of international criminal tribunals, with the effect of excluding cases involving alleged grave crimes by actors whose presence in situations of w
The possibility of prosecuting serious international crimes before domestic foreign courts when territorial courts are unwilling and unable to perform this function and international criminal tribunals with suitable competences are unavailable has been intensively debated since the time of the Spanish arrest warrants against Pinochet. The African disapproval of decisions by European courts to exer
The public sector is showing increased interest in Mobility as a Service (MaaS), as its introduction and market penetration is proposed to potentially disrupt the personal transport system. However, involved public actors are approaching MaaS very differently. This paper applies a neo-institutional perspective to study the activities of public actors in the ongoing development of MaaS in Finland a
Earth system models (ESMs) are key tools for providing climate projections under different scenarios of human-induced forcing. ESMs include a large number of additional processes and feedbacks such as biogeochemical cycles that traditional physical climate models do not consider. Yet, some processes such as cloud dynamics and ecosystem functional response still have fairly high uncertainties. In t
One way of valorizing the lignin waste stream from the pulp and paper industries is depolymerizing it into low-molecular-mass compounds (LMMC). However, a common problem in the depolymerization of Kraft lignin is the low yields of small aromatic molecules obtained. In the present work, the combination of the repeated depolymerization of lignin and the separation of LMMC from depolymerized lignin t
The project examines how grassroots organizations and networks providing urban critical services in informal settlements contribute to improve the quality of life of urban dwellers and to more inclusive forms of urban governance, constructing the city from below.The project is informed by the study of Kisumu’s informal settlements’ Resident Associations, the Water Delegated Management Model, and t
Kindling, induced by repeated subconvulsive electrical or chemical stimulations leads to progressive and permanent amplification of seizure activity, culminating in generalized seizures. We report that kindling induced by electrical stimulation in the ventral hippocampus leads to a marked and transient increase of mRNA for NGF and BDNF in the dentate gyrus, the parietal cortex, and the piriform co
A simple and sensitive immunoradiometric assay for the detection of islet cell surface antibodies (CIRMA) has been developed. Live, transformed islet cells derived from a liver metastasis of a transplantable islet cell tumor were grown in removable microtiter wells and incubated with antibody. Cell-bound antibodies were quantitated using 125I-labelled second antibodies. The assay was used to detec
Polymer films based on mixtures of ethyl cellulose (EC) and hydroxypropyl cellulose (HPC) have been widely used to coat pellets and tablets to modify the release profile of drugs. For three different EC/HPC films we used 1H and 19F MRI in combination with a designed release cell to monitor the drug, polymer and water in 5 dimensional (5D) datasets; three spatial, one diffusion or relaxation and a
The loss of p53 induces spontaneous tumors in mice, and p53 mutations are found in approximately 50% of human tumors. These tumors are generally caused by a number of events, including genomic instability, checkpoint defects, mitotic defects, deregulation of transcriptional targets, impaired apoptosis, and G 1 deregulation or a combination of these effects. In order to determine the role of protei
