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Several studies suggest that the apolipoprotein E (APOE) ε4 allele modulates cerebrospinal fluid (CSF) levels of β-amyloid 42 (Aβ42). Whether this effect is secondary to the association of the APOE ε4 allele with cortical Aβ deposition or whether APOE ε4 directly influences CSF levels of Aβ42 independently of Aβ pathology remains unknown.
-Plasma lipid levels as well as coronary artery disease (CAD) have been shown to be highly heritable with estimates ranging from 40%-60%. However, top variants detected by large-scale genome-wide association studies (GWAS) explain only a fraction of the total variance in plasma lipid phenotypes and CAD.
This study presents the institutional experience of the use of vomer flap for early closure of hard palate during unilateral complete cleft-lip repair. The purpose of this study was to determine the survival rate of the vomer flap and to investigate its effect on the subsequent palatoplasty.
In a recent article Emanuel Adler and Vincent Pouliot argued that attention to 'practices' could help IR scholars overcome ontological gaps and provide a new basis, on which the discipline could be established. Four such dichotomies are particularly salient: between the material and the meaningful, the rational and the practical, between agencies and structures, and between the forces of stability
Results based on virtual instrument models for the first high-flux, high-resolution, spallation based, backscattering spectrometer, BASIS are presented in this paper. These were verified using the Monte Carlo instrument simulation packages McStas and VITESS. Excellent agreement of the neutron count rate at the sample position between the virtual instrument simulation and experiments was found, in
A practical inversion method to calculate the size distribution of colloidal homogeneous particles from small-angle scattering experiments is presented. It is based on the analysis of the deviations of the scattering signal from the Porod law. The resulting inversion formula provides a reliable way to assess complex size distributions such as power-law, multimodal or very broad distributions. It i
Multiple nerve branches were created during the regeneration procedure after a nerve injury and such multiple branches are suggested to be used to control, for example, prosthesis with many degrees of freedom. Transected rat sciatic nerve stumps were inserted into a nine mm long silicone tube, which contained four, five mm long, smaller tubes, thus leaving a five mm gap for regenerating nerve fibe
Abstract Background. It has been debated whether or not heparin infusion before or after non-heart-beating donors are declared dead improves the quality of pulmonary grafts. In clinical lung transplantation with heart-beating donors (HBDs) heparin is routinely infused prior to organ harvesting since it is believed to improve pulmonary grafts by minimizing thrombosis formation in the pulmonary graf
We report on the characterization of the new I1011 beamline at the MAX-II storage ring, in the MAX-lab synchrotron radiation laboratory and give examples of first results. This beamline is using an Elliptically Polarizing Undulator source, producing soft x-rays of a variable polarization state. It delivers high flux and high brightness circularly polarized x-rays in the energy range 0.2 to 1.7 keV
In many countries, practice-oriented programs have been recast as university programs, fueling debate on the purpose of higher education. We highlight two ways of talking about the challenges for higher education we think are already familiar to readers. We label them ‘political-worry discourse’ and ‘academic-worry discourse’. We argue for a third position that gives due recognition to the turn in
Purpose – The purpose of this paper is to examine the influence that family factors have on an individual’s intention to be self-employed. Design/methodology/approach – The authors selected, from Swedish national registers, all full siblings born between 1945 and 1960 and their biological children, who were born before 1985. The authors created one family database consisting of male individuals (n
Economic significance is frequently assessed through statistical hypothesis testing, which however, does not always correspond to the implicit economical questions being addressed. In this article we propose using mean value decomposition to assess economic significance. Unlike most previously suggested methods the proposed one is intuitive and simple to conduct. The technique is demonstrated and
A trade-off between survival to sexual maturity and mating success is common across alternative reproductive tactics (ARTs), and can lead to tactical disruptive selection on shared traits (i.e. positive selection gradient in one tactic, and negative selection gradient in another). We were interested in examining the theoretical possibility of tactical disruptive selection on intrinsic growth rate.
Autoantibodies termed C3-nephritic factor (C3NeF), which stabilize convertases of the alternative complement pathway, often stimulate autoinflammatory diseases. However, knowledge about analogous autoantibodies acting on the classical pathway (C4NeF) is limited to a few reports, which indicate association with kidney dysfunction, systemic lupus erythematous, and infections. C4NeF may appear indepe
In this paper the development of an extension module to the IWA/COST simulation benchmark to include expert reasoning is presented. This module enables the detection of suitable conditions for the development of settling problems of biological origin (filamentous bulking, foaming and rising sludge) when applying activated sludge control strategies to the simulation benchmark. Firstly, a flow diagr
Purpose: SCOPA-SLEEP is a rating scale for night-time sleep and daytime sleepiness (DS) proposed for use among people with Parkinson’s disease (PD) as well as others. We translated it into Swedish and assessed its psychometric properties in PD and age-matched healthy controls. Methods: Following translation according to the dual-panel approach, the Swedish SCOPA-SLEEP was field-tested regarding co
