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Historically, aerosols of anthropogenic origin have offset some of the warming from increased atmospheric greenhouse gas concentrations. The strength of this negative aerosol forcing, however, is highly uncertain-especially the part originating from cloud-aerosol interactions. An important part of this uncertainty originates from our lack of knowledge about pre-industrial aerosols and how many of

Background: In prostate cancer (PCa), questions remain on indications for prostate-specific membrane antigen (PSMA) positron emission tomography (PET) imaging and PSMA radioligand therapy, integration of advanced imaging in nomogram-based decision-making, dosimetry, and development of new theranostic applications. Objective: We aimed to critically review developments in molecular hybrid imaging an

Land cover governs biogeophysical and biogeochemical feedbacks between the land surface and atmosphere. Holocene vegetation-atmosphere interactions are of particular interest, both to understand the climate effects of intensifying human land use and as a possible explanation for the Holocene Conundrum, a widely studied mismatch between simulated and reconstructed temperatures. Progress addressing

Phosphorus (P) is a critical macronutrient for plant growth, often limiting plant production in areas where plant demand is higher than soil supply. In contrast to nitrogen (N), P cannot be sourced from the atmosphere; therefore, where it is rare, it becomes a strong constraint on primary production. Due to this, most dynamic global vegetation models (DGVMs) are incorporating a prognostic P cycle

Pollen analyses and AMS C-14 measurements were performed on lacustrine sediments and peat sequences from two former crater lakes (Preluca Tiganului, Steregoiu) situated in the Gutaiului Mountains in northwestern Romania, in order to reconstruct the vegetation development during the Lateglacial and Early Holocene. Before c. 14,700 cal. years BP (GS-2) open vegetation with shrubs (Salix, Juniperus),

Despite the fact that caring has been regarded as the core of nursing for decades, our knowledge about caring is still mainly on a philosophical level. The problem with these philosophical descriptions is that they do not serve as explicit guides for today's nurses, particularly in the light of the considerable changes that have taken place in the healthcare sector. One of the aims of this thesis

Popular Abstract in Swedish Närmare 30.000 svenskar drabbas årligen av stroke (slaganfall). I ungefär 85 % av fallen är orsaken en blodpropp i ett av hjärnans kärl s.k. hjärninfarkt. En avstängning av blodflödet orsakar en snabbt insättande förlust av funktionen i det drabbade området, t.ex. halvsidig förlamning, bortfall av delar av synfältet liksom störning av olika högre hjärnfunktioner såsom mAbstract Stroke is the third leading cause of death in the western world, and the number one cause of disability. 85% of all strokes are ischemic. Most stroke survivors will experience recovery of function. The mechanisms behind this improvement are partly unknown, but may involve elements of both compensation and restoration. Exposure to an enriched environment (EE) that stimulates social interac

Popular Abstract in Swedish Proteiner är helt nödvändiga för alla former av liv på jorden. En typisk cell består till 50-60 % av proteiner, om man bortser från vatten. Det är ett protein, hemoglobin, som transporterar syre från lungorna till kroppens celler och ger blodet dess röda färg. Det är ett protein, alfa- keratin, som bygger upp vårt hår och våra naglar. Det är två proteiner, aktin och myoProtein S is a modular protein and a cofactor in the protein C anticoagulant system. It consists of a Gla-module, a thrombin-sensitive loop, four EGF-modules and a SHBG-like module. Protein S has previously been shown to contain four binding sites with high affinities for Ca²⁺ (K_a>9x10⁵ M^-1 at physiological ionic strength) and at least one of the sites h

A youth care institution may seem like a sort of regulated home. It does not resemble a home in the sense of a private household, and the youth living there usually do not define it as a home, but it seems like a home in the sense of being a place where youth in treatment spend most of their days and nights. But is that what a home is? In many cases, people in modern societies are not supposed to

Popular Abstract in Swedish Lokal läkemedelsstatistik – ett verktyg för att identifiera problemområden och att bedöma effekter av information och utbildning om läkemedel. Det finns behov att studera läkemedelsförskrivning och läkemedelsanvändning och dessas samband med och effekter på hälsa, sjuklighet och överdödlighet. Det är också önskvärt att kunna använda individdata. I Sverige är det i allmAims: 1) To assess if drug sales data indicate differences in morbidity, mortality, socio-economic conditions and deviating prescribing habits among physicians; 2) to identify areas for educational interventions and to analyse changes in prescribing after educational activities. In addition, an effort was made to estimate differences between pharmacy sales and purchases by the population, and the

This thesis presents methods for improving the accuracy and efficiency of tasks performed using different kinds of industrial manipulators, with a focus on the application of machining. Industrial robots offer a flexible and cost-efficient alternative to machine tools for machining, but cannot achieve as high accuracy out of the box. This is mainly caused by non-ideal properties in the robot joint

Popular Abstract in Swedish Diabetes mellitus är en endokrin sjukdom. Hos friska individer producerar beta och alpha cellerna i bukspottkörteln insulin och glukagon, de viktigaste hormonerna för att reglera blodglukos¬koncentrationen. Insulin utsöndras som svar på förhöjda blodglukosnivåer. Hormonet minskar glukosproduktion från levern och ökar glukosupptaget samt dess användning och lagring i fetType 2 Diabetes (T2D) is a multifactorial disease, which has made it difficult to resolve its pathophysiology. We investigated processes that could contribute to the development of T2D. In addition to well-known hallmarks of the disease, such as defective insulin secretion, insulin resistance and perturbed glucagon secretion, we aimed to find a possible role for CLOCK genes in the pathogenesis of

Hematopoietic stem cells (HSC), the ancestors of all blood cells, have the ability to give rise to mature effector cells through a series of developmental steps. This is a tightly regulated, though a highly dynamic process: on the one hand, dysregulation in steady-state could lead to under- or overgrowth of certain blood cell lineages, whereas, on the other hand, demands for certain mature blood c

The incidence of Diabetes Mellitus increases globally in epidemic proportions. Type 2 Diabetes is the most prevalent form of Diabetes, comprising 90% of the patients. In Type 2 Diabetes, two processes contribute to the development of the disease: insufficient insulin secretion from the pancreatic ?-cell and insulin resistance of the target organs. This leads to loss of control of blood glucose lev

Popular Abstract in Swedish Sammanfattning Teknik är alltid skapad för en förväntad brukare i ett antaget sammanhang. Inom kommersiell luftfart är dessa antaganden när det gäller design tydliga. Såväl besättning som utrustning är certifierad för en viss typ av operationer i enlighet med flygplanets drifthandbok. Trots denna genomtänkta definition av användare i sitt sammanhang händer det ändå attAbstract Technology is always designed for an assumed user in an assumed context. In commercial aviation, these design assumptions are clearly spelt out in that both crew and equipment are certificated for a specific operation as stated in the aircraft flight manual. Despite this well defined user context, the designed-for and the real contexts often differ enough so that adaptations of working p

Today, as a rule, the most cost-effective way to remove nitrogen from municipal wastewater is the biological method based on nitrification and subsequent denitrification. All biological systems may be affected by toxicants, and biological nitrogen removal is no exception. An investigation of influent wastewaters from 109 Swedish municipal wastewater treatment plants was accomplished. Inhibitory s

Popular Abstract in German Spannungsgesteuerte Kalziumkanäle haben eine große Bedeutung in vielen elektrisch erregbaren Zellen, wie z.B. in Nervenzellen und pankreatischen beta-Zellen. Hier werden sie folgendermaßen aktiviert: In der Nahrung enthaltener Traubenzucker (Glukose) wird nach einer Mahlzeit über den Blutstrom im Körper verteilt und in die beta-Zellen über Glukosetransporter aufgenommen.Voltage-gated Ca2+ channels are essential transducers of cellular signals in many electrically excitable cells. In the pancreatic beta-cell they mediate controlled Ca2+ influx, which is the final trigger for Ca2+ dependent release (exocytosis) of the blood glucose lowering hormone insulin. Several subtypes of voltage-gated Ca2+ channels are known and the L-type has been found to be the main contri

The work presented in this thesis focuses on developing methods of measuring moisture properties at high moisture levels. Paper I deal with a new method of measuring moisture diffusivity at high moisture levels. Papers II to IV present methods of measuring moisture storage capacity as well as results from such measurements. Paper V evaluates the use of thermal imaging to measure transient moisture

Brämhults Juice AB is a Swedish company producing fresh juice for the Scandinavian market. Fresh juice is rich in taste but has limited durability and must be treated with special care throughout the whole supply chain. Not only will the quality of the product be affected if mistreated, but there are also contamination risks meaning that people actually could get sick, although the risk is very sm