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BACKGROUND: The isolation of cell-free DNA (cfDNA) from the bloodstream can be used to detect and analyze somatic alterations in circulating tumor DNA (ctDNA), and multiple cfDNA-targeted sequencing panels are now commercially available for Food and Drug Administration (FDA)-approved biomarker indications to guide treatment. More recently, cfDNA fragmentation patterns have emerged as a tool to inf
Cell cycle regulation, especially faithful DNA replication and mitosis, are crucial to maintain genome stability. Cyclin-dependent kinase (CDK)/cyclin complexes drive most processes in cellular proliferation. In response to DNA damage, cell cycle surveillance mechanisms enable normal cells to arrest and undergo repair processes. Perturbations in genomic stability can lead to tumor development and
För att svensk järnvägsinfrastruktur skall kunna vara konkurrenskraftig i jämförelse med mindre miljövänliga alternativ krävs kapacitetsutbyggnad och hastighetsökning av det svenska järnvägsnätet. Vid hastigheter över 200 km/h finns krav på att dynamiska analyser behöver utföras. För vissa brotyper, exempelvis samverkansbroar med ändskärmar, är det svårt att påvisa acceptabel vertikal accelerationFor Swedish railway infrastructure to be competitive compared to less environmentally friendly alternatives, capacity expansion and speed increase of the Swedish rail network are required. At speeds above 200 km/h, dynamic analyses are required by code. For some bridge types, such as composite bridges with end screens, there are difficulties in meeting the requirements for vertical acceleration in
Background: Out-of-hospital cardiac arrest (OHCA) survivors and their relatives may face challenges following hospital discharge, relating to mood, cognition, and returning to normal day-to-day activities. Identified research gaps include a lack of knowledge around what type of intervention is needed to best navigate recovery. In this study, we investigate the feasibility and patient acceptabilityBackground: Out-of-hospital cardiac arrest (OHCA) survivors and their relatives may face challenges following hospital discharge, relating to mood, cognition, and returning to normal day-to-day activities. Identified research gaps include a lack of knowledge around what type of intervention is needed to best navigate recovery. In this study, we investigate the feasibility and patient acceptability
BACKGROUND: The risk of venous thromboembolism is high after total hip arthroplasty and could persist after hospital discharge. Our aim was to compare the use of rivaroxaban for extended thromboprophylaxis with short-term thromboprophylaxis with enoxaparin.METHODS: 2509 patients scheduled to undergo elective total hip arthroplasty were randomly assigned, stratified according to centre, with a comp
Doktorsavhandlingen ger inblick i en betydelsefull konsekrerande beslutsprocess inom det svenska konstfältet under perioden 1885–1920. Den analyserar de sociala strukturer som bar fram Nationalmuseums inköpsnämnds och museinämnds årliga beslutsförslag till Kungl. Maj:t om vilka oljemålningar, skapade av vid tiden levande svenska konstnärer, som skulle inlemmas i samlingarna och vilka som skulle exThis dissertation examines the Swedish National Museum of Fine Arts (Nationalmuseum) as a consecrating institution of fine art, between 1885 and 1920. A time influenced by major events such as the First World War, Sweden’s industrial revolution and the advent of universal suffrage. During this period, the production and consumption of the Arts was characterised by rivalry between three fractions,
This paper re-focuses the Silk Road discussions from the position of contemporary art in Central Asian region. Since the late 1980s contemporary art in Central Asia boomed and it eventually became an alternative public space for the discussion of cultural transformations, social and global processes and problems that local societies faced. Initially the questions raised by many artists concerned i
The purpose of the dissertation is to trace the working process of Johannes Widekindi (ca 1620–1678), Swedish historiographer of the Realm, when writing his bilingual history of the Swedish military actions in Russia in 1609–1617, published in 1671 in Swedish as Thet Swenska i Ryssland tijo åhrs Krijgz-Historie and in 1672 in Latin as Historia Belli Sveco-Moscovitici Decennalis.Chapter 1 of the di
In this thesis fabrication and optimization of vertical III-V Tunneling Field-Effect transistors was explored. Usage of vertical nanowires, allows for combination of materials with large lattice mismatch in the same nanowire structure. TFETs in this thesis were fabricated using vertical InAs/GaSb or InAs/InGaAsSb/GaSb nanowires of high material quality. Usage of these material systems allowed for
The free Modelica library ThermoFluid was developed for simulation ofthermo-hydraulic applications, both for single-species applicationslike the water-steam cycle in a thermal power plant and formulti-species applications with gas mixtures. It has demonstratedits flexibility for modeling thermodynamic and process applicationsin a variety of industrial and academic projects. This articledescribes h
Assessment of amyloid deposits is a critical step for the identification of Alzheimer disease (AD) signature in asymptomatic elders. Whether the different amyloid processing methods impacts on the quality of clinico-radiological correlations is still unclear. We directly compared in 155 elderly controls with extensive neuropsychological testing at baseline and 4.5 years follow-up three approaches:
OBJECTIVES: To simplify the previously published Nottingham 12-year risk prediction model for knee osteoarthritis (OA) and examine whether it can be used to predict the 40-year risk of knee OA in young men.METHODS: We included 40 118 men aged 18 undergoing military conscription in Sweden 1969-70. Diagnostic OA codes were obtained from the Swedish National Patient Register 1987-2010. The original N
Metal cutting is a very common operation in the manufacturing industry. Drilling and other hole-making operations perhaps account for 50% of all metal cutting, according to some investigations. All metal cutting including drilling always produces burrs, as a by-product. Actually burrs are nothing but uncut metal at the beginning and at the end of the operations. Yet, despite burr's omnipresence in
The ordered c(2×2) Na on Al(100) and (3 × 3) R30°K on Al(111) structures formed at either 100 K or at room temperature are studied by high-resolution core-level spectroscopy. For both systems equal alkali coverages are found at these two temperatures. The core-level spectra, however, show strong changes with temperature. This behavior leads to the surprising conclusion that annealing at room tempe
Chemistry and Climate Change (5hp) This is a specialized course that will utilize a reading seminar/peer-review format to revisit the state-of-the-knowledge regarding certain topical themes in atmospheric chemistry and climate. Previously, similar courses have focused on reviewing (i) a 2012 special edition “Atmospheric Chemistry” in Chemical Society Reviews and (ii) the IPCC WGI report, Climate C
https://www.cec.lu.se/sites/cec.lu.se/files/kursplan_chemistry_and_climate_change_2017.pdf - 2026-05-19
Rapport vecka 40 (publicerad 2020-10-07) COVID Symptom Study Innehåll Bakgrund 2 Metod 2 Etiskt godkännande 5 Aktuell status 5 10 postnummerområden med lägst andel studiedeltagare med symtom överensstämmande med covid-19 den 5 oktober . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 Störst ökning senaste 7 dagarna . . . . . . . . . . . . . . . . . . . . . . . . . .
https://www.covid19app.lu.se/sites/covid19app.lu.se/files/rapport_vecka40_coss.pdf - 2026-05-19
