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Treatment for Acute Anterior Cruciate Ligament Tear in Young Active Adults

BACKGROUND Anterior cruciate ligament (ACL) injury of the knee is common in young active adults and often has severe and sometimes lifelong consequences. The clinical management of this injury remains debated. A prior trial of early versus delayed optional ACL repair showed no differences in outcomes at 2 years. METHODS We present the 11-year follow-up of a randomized clinical trial involving 121

Coronary Artery Lesion Lipid Content and Plaque Burden in Diabetic and Nondiabetic Patients : PROSPECT II

BACKGROUND: Patients with diabetes have increased rates of major adverse cardiac events (MACEs). We hypothesized that this is explained by diabetes-associated differences in coronary plaque morphology and lipid content. METHODS: In PROSPECT II (Providing Regional Observations to Study Predictors of Events in the Coronary Tree), 898 patients with acute myocardial infarction with or without ST-segme

Empowerment and enablement and their associations with change in health-related quality of life after a supported osteoarthritis self-management programme - a prospective observational study

BACKGROUND: Osteoarthritis is a leading cause of disability worldwide. Current treatment supports coping strategies to improve health-related quality of life (HRQoL). The need to predict response to treatment has been raised to personalise care. This study aims to examine change in HRQoL from baseline to three and nine months follow-up after participating in a Supported Osteoarthritis Self-Managem

Genetic Moderation of the Association of β-Amyloid With Cognition and MRI Brain Structure in Alzheimer Disease

Background and Objectives: There is considerable heterogeneity in the association between increasing β-amyloid (Aβ) pathology and early cognitive dysfunction in preclinical Alzheimer disease (AD). At this stage, some individuals show no signs of cognitive dysfunction, while others show clear signs of decline. The factors explaining this heterogeneity are particularly important for understanding pr

Neuropsychological outcome after cardiac arrest : results from a sub-study of the targeted hypothermia versus targeted normothermia after out-of-hospital cardiac arrest (TTM2) trial

Background: Cognitive impairment is common following out-of-hospital cardiac arrest (OHCA), but the nature of the impairment is poorly understood. Our objective was to describe cognitive impairment in OHCA survivors, with the hypothesis that OHCA survivors would perform significantly worse on neuropsychological tests of cognition than controls with acute myocardial infarction (MI). Another aim was

Retained Metabolic Flexibility of the Failing Human Heart

Background: The failing heart is traditionally described as metabolically inflexible and oxygen starved, causing energetic deficit and contractile dysfunction. Current metabolic modulator therapies aim to increase glucose oxidation to increase oxygen efficiency of adenosine triphosphate production, with mixed results. Methods: To investigate metabolic flexibility and oxygen delivery in the failing

Surgical outcomes of gallbladder cancer: the OMEGA retrospective, multicentre, international cohort study

Background: Gallbladder cancer (GBC) is rare but aggressive. The extent of surgical intervention for different GBC stages is non-uniform, ranging from cholecystectomy alone to extended resections including major hepatectomy, resection of adjacent organs and routine extrahepatic bile duct resection (EBDR). Robust evidence here is lacking, however, and survival benefit poorly defined. This study ass

Transatlantic multicenter study on the use of a modified preloaded delivery system for fenestrated endovascular aortic repair

Objective: Analyze the outcomes of endovascular complex abdominal and thoracoabdominal aortic aneurysm repair using the Cook fenestrated device with the modified preloaded delivery system (MPDS) with a biport handle and preloaded catheters. Methods: A multicenter retrospective single arm cohort study was performed, including all consecutive patients with complex abdominal aortic aneurysm repair an

In-depth studies on sex trafficking in women: the case of justice response, jurisprudence and human rights in Southeastern Europe

Sex trafficking has from six hundred thousand to four million victims each year (McCabe and Manian, 2010: 41-43). Because of different legal barriers, sex trafficking is closely associated with organized crime; crime victims often do not search for support from legal systems, law enforcement authorities, or other officials (ibid.) This thesis was to understand how law affects the ability of preven

Achievment of sustainable solid waste management in developing countries

With an increasingly population and urbanization, the solid waste management have become a major challenge for local authorities in developing countries all over the world. The local authorities must improve their waste management in order to minimize the negative effects of solid waste and to avoid future land use conflicts. At the same time the economical resources are limited and solid waste ma

Advanced decision support methods for solving diffuse water pollution problems

Dealing with water diffuse pollution is a major problem for watershed managers. This problem raises many complicated questions, which are important to answer in order to reach water environment protection goals. This study suggested some possible answers for the country of Lithuania. Among them were the identification of critical source areas, the identification of sensitive areas and the applicat

Can Dwarf Galaxies Tell Us How the Milky Way Formed?

Dwarf galaxies are a key component in understanding the evolution of galaxies and provide tests on the standard cosmological $\Lambda$ Cold Dark Matter model. According to the formation hierarchy, dwarf galaxies are the pieces that create all galaxies. Our current understanding of dwarf galaxies faces discrepancies between theory and observations. These problems are mostly due to incompleteness in

Street-level greenery mapping and urban heat modelling using deep learning and street view imagery

In an urbanizing world, challenged by climate change and rising temperatures, street vegetation can help mitigate urban temperatures. However, scaling the understanding of street vegetation’s cooling effects from local observations to the city level introduces challenges. While several studies have assessed the influence of street greenery on land surface temperature (LST) at the city scale using

What are the trends and drivers of riverine CO2 emissions in the Tibetan Plateau?

The release of carbon dioxide (CO2) from inland waters plays an important role in the global carbon cycle. Yet, there are uncertainties related to estimating riverine CO2 evasion (FCO2), especially in data scarce regions such as the Tibetan Plateau. It is unclear how global change in the form of climate warming and anthropogenic disturbance affects emissions. This study reports annual CO2 fluxes a

Synergi, ett digitalt rapporteringsverktyg för arbetsmiljö

Title: Synergi, a digital reporting tool for working environment. Authors: Sebastian Larsson & Joel Ståhl Supervisor: Radhlinah Aulin, Senior lecturer at the Department of Building and Environmental Technology, Division of Construction Management, Lund University. Examinator: Anne Landin, Professor at the Department of Building and Environmental Technology, Division of Construction Management,

Analysis of vibrations in high-tech facility

MAX-lab is a national synchrotron radiation facility in Lund. Nowadays, the MAX project consist of three facilities (three storage rings). A new storage ring is needed to improve material science, such as nanotechnology. MAX IV, also in Lund, will be 100 times more efficient than already existing synchrotron radiation facilities. The storage ring is controlled by a large number of magnets that are

Absorbed dose distributions in the vicinity of high-density materials in head and neck radiotherapy A quantitative comparison between measurements, Monte Carlo simulations and treatment planning system

Varje år diagnostiseras i Sverige ungefär 1100 personer med cancer i huvudhalsregionen. Typiska diagnoser är tungcancer, läppcancer och cancer i struphuvudet. I och runt om munhålan finns det stora skillnader i densitet mellan till exempel vävnad och tänder och vävnad och tandlagningar. I detta arbete så har effekterna av ett antal olika tandlagningsmaterial på dosberäkningarna undersökts. För a"Introduction: Around 1.000 people are diagnosed with head and neck cancer in Sweden every year. Radiotherapy is often used to treat these tumors. When irradiating patients in the head and neck area there are some problems. One of these problems is the large difference in density between the oral tissue and dental materials. Another problem is the image artifacts due to high-density materials

Monte Carlo Simulations of a Clinical PET system using the GATE Software

Monte Carlo-simuleringar har fått en ökad betydelse som forskningsverktyg inom nuklearmedicinsk bildgivning eftersom man på ett mycket kontrollerat sätt kan studera nästan vad man vill. I denna studie har datorsimuleringar av ett PET-system gjorts med ett program som heter GATE. PET (Positron Emission Tomography) är en nuklearmedicinsk bildgivningsteknik som används mer och mer inom sjukvården sIntroduction: Monte Carlo simulation is a powerful tool in research in the field of nuclear medicine imaging and there is a wide area of applications. The purpose of this work was (1) to understand the basics of the Monte Carlo simulation software Geant4 Application for Tomographic Emission (GATE); (2) to create a model of Philips Gemini TF PET/CT system; (3) to run a number of simulations to comp