Filetype
Background Multiple myeloma cells uniformly overexpress CD38. We studied daratumumab, a CD38-targeting, human IgG1κ monoclonal antibody, in a phase 1-2 trial involving patients with relapsed myeloma or relapsed myeloma that was refractory to two or more prior lines of therapy. Methods In part 1, the dose-escalation phase, we administered daratumumab at doses of 0.005 to 24 mg per kilogram of body
Background. Several clinical studies have suggested possible increase in cardiovascular risk during and in the first weeks after an acute inflammatory disease. Using influenza vaccine as inflammatory stimulus, we investigated whether arterial endothelial dysfunction could persist beyond the inflammatory state, and whether amplified oxidative modification of low-density lipoprotein (LDL) accompanie
Precipitation is often the sole source of water replenishment in arid and semi-arid areas and, thus, plays a pertinent role in sustaining desert ecosystems. Revegetation over 40 years using mainly Artemisia ordosica and Caragana korshinskii at Shapotou Desert Experimental Research Station near Lanzhou, China, has established a dwarf-shrub and microbiotic soil crust cover on the stabilized sand dun
Previous cytogenetic studies of myeloid and acute lymphoblastic leukemias in children with Down syndrome (ML-DS and DS-ALL) have revealed significant differences in abnormality patterns between such cases and acute leukemias in general. Also, certain molecular genetic aberrations characterize DS-related leukemias, such as GATA1 mutations in ML-DS and deregulation of the CRLF2 gene in DS-ALL. Wheth
BACKGROUND: Maintenance of the botanical integrity of cereal kernels and the addition of acetic acid (as vinegar) in the product or meal has been shown to lower the postprandial blood glucose and insulin response and to increase satiety. However, the mechanism behind the benefits of acetic acid on blood glucose and satiety is not clear. We hypothesized that the gastric emptying rate could be invol
Certain pesticides may affect children's neurodevelopment. We assessed whether pesticide exposure was associated with impaired neurobehavioral outcomes in children aged 6–9 years. We conducted a cross-sectional study in 140 children living near banana plantations and plantain farms in the Talamanca County, Costa Rica and assessed their neurobehavioral performance. Exposure was determined by analyz
Background: Our hypothesis was that a modified diet would improve blood glucose control with beneficial impact on weight management and overall health in established diabetes. Objective: This prospective interventional study investigated the clinical effect of an Okinawan-based Nordic diet on anthropometry, metabolic control, and health-related quality of life (HRQoL) in Scandinavian type 2 diabet
Summary: This study used nationwide hip fracture data from Denmark and Sweden during 1987–2010 to examine effects of (birth) cohort and period. We found that time trends, cohort, and period effects were different in the two countries. Results also indicated that hip fracture rates may increase in the not so far future. Introduction: The reasons for the downturn in hip fracture rates remain largely
The Eastern Mediterranean Region (EMR) is witnessing an increase in chronic disorders, including mental illness. With ongoing unrest, this is expected to rise. This is the first study to quantify the burden of mental disorders in the EMR. We used data from the Global Burden of Disease study (GBD) 2013. DALYs (disability-adjusted life years) allow assessment of both premature mortality (years of li
This report describes a model for the estimation of the time required to evacuate a building, by dividing the evacuation process into three phases: awareness, behaviour and response, and movement. The times required in each of these phases can be estimated separately and the sum then represents the total evacuation time. The time elapsed from the fire breaking out, to the discovery of the fire, is
Popular Abstract in Swedish Huvudsyftet med den utförda forskningen var att öka förståelsen för hur variabiliteten hos styrkevärden i trä påverkar tillförlitligheten hos en träkonstruktion. Jämfört med andra byggnadsmaterial som tex stål och betong har trä markant högre variabilitet i styrke- och styvhetsegenskaper både mellan och inom element. I byggnadsnormer tar man generellt inte hänsyn till The main purpose of the performed research presented in this thesis is to increase the understanding of the effect of variability of strength properties on the reliability of timber structural systems. Compared to other structural materials such as steel and concrete, structural timber has a considerably higher variability of strength both within and between members. The advantage of the low proba
Due to increased urbanisation, and climate change, there have been calls for a more sustainable management of stormwater. Blue-green measures have been recognised as a sustainable solution and a necessary complement to pipe-bound approaches. The aim of this study is to identify barriers and drivers in the implementation of blue-green measures in a Swedish context, to increase the understanding of
Access to compatible blood for transfusion is a prerequisite for modern health care. The compatibility is limited by the presence of antibodies to blood group antigens, polymorphic protein and carbohydrate structures, on the surface of the red blood cell. Blood group antigens arise from genetic variation in the genes underlying their expression. Knowledge of these genes and their variation can fac
Byggbranschen är i dagsläget en av de störst bidragande faktorerna till utsläpp av fossila bränslen i Sverige och besitter en stor utvecklingspotential beträffande reducering av klimatpåverkan. En byggnads klimatpåverkan under en livscykel kan beräknas genom metoden livscykelanalys, som inkluderar en produkts, eller i detta fall en byggnads, klimatpåverkan från råvaruutvinning till avfallshanterinThe construction industry is currently one of the largest contributing sources to carbon dioxide emissions in Sweden and has great development potential in reducing its climate impact. Since January 2022, the Swedish government requires a declaration of the climate impact of each recently constructed building. To calculate the climate impact of a building, the life cycle assessment tool is used, a
Amazing scissors or revolutionizing treatments? Autoimmune diseases, cancer and allergies are something that is on the rise in the Western world and can cause major problems in everyday life, in the worst case even death. In addition to that, we have a growing problem with antibiotic-resistant bacteria and increased complications for both healthy people, and especially for those who already have
By increasing the amount of CO2 emissions to the atmosphere because of using fossil fuel and the limitation of non-renewable energy sources, solar photovoltaics technology has been growing steadily and is thought to play an important role in the realm of future energies. The objective of this thesis is to investigate the potential of the rooftops for installing PV system on a small scale of 30 mu
Rapporten är ett examinerande moment i kursen Brandteknisk riskvärdering. Syftet med rapporten är att utvärdera personsäkerheten vid brand för besökarna på Halmstadtravet och ge förslag på eventuella förbättringar. Syftet är även att studenterna ska tränas i sin ingenjörsmässiga förmåga. I byggnaden som utvärderas finns bland annat restaurang, kök, sittplatsläktare och caféverksamhet. Det redogörThe report is an examination element of the course Brandteknisk riskvärdering. The purpose of the report is to evaluate human safety of visitors in case of fire at the racetrack Halmstadtravet and suggest possible solutions if the human safety is deemed insufficient. The purpose is also to train the students in their engineering capability. The method is to choose several fire scenarios that chal
The theoretical focus in this master is information retrieval (IR), and especially the part of IR that includes interactivity. This research is by some researchers called IIR. Our principal aim was to examine if search engines on the WWW are taking advantage of research results from IIR research. A way to do this is to look at the application of special features, in this case query expansion (QE)
A review was performed of eight previously performed investigations of environmental impacts from end-consumer food waste prevention. The overall aim of the study was to investigate the state of the art in these assessments, identify key factors which could explain seen variations in GWP-emission savings, and suggest methodological improvements leading to increased potentials for cross-study compa
During more than three decades, corporate non-financial and sustainability reporting has been widely conceived as a voluntary practice, a matter of going beyond the requirements of the law. Therefore, it has been traditionally overlooked by legal and socio-legal scholars. However, during the last decade things have rapidly changed. We are currently witnessing the emergence of a mix of mandatory a
