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Rodent models have been developed to study the pathogenesis of diseases caused by Helicobacter pylori, as well as by other gastric and intestinal Helicobacter spp., but some murine enteric Helicobacter spp. cause hepatobiliary and intestinal tract diseases in specific inbred strains of laboratory mice. To identify these murine Helicobacter spp., we developed an assay based on PCR-denaturing gradie
About 25% of C2-deficient homozygotes have increased susceptibility to severe bacterial infections. C2-deficient homozygotes had significantly lower serum levels of IgG2, IgG4, IgD, and Factor B, significantly higher levels of IgA and IgG3 and levels of IgG1 and IgM similar to controls. Type I ( 28 bp deletion in C2 exon 6 on the [HLA-B18, S042, DR2] haplotype or its fragments) and type II ( non-t
BACKGROUND AND OBJECTIVES: During the past 10 years several DNA-typing methods have been developed to complement routine serological typing for determination of polymorphisms in the ABO, RH, KEL, JK and FY blood group genes. However, the molecular basis of blood groups can differ widely between ethnic groups. The purpose of this study was to evaluate selected DNA-based methods for phenotype predic
Background: Interactions between Th1 and Th2 immune responses are of importance to the onset and development of allergic disorders. A Toll-like receptor 7 agonist such as AZD8848 may have potential as a treatment for allergic airway disease by skewing the immune system away from a Th2 profile. Objective: To evaluate the efficacy and safety of intranasal AZD8848. Methods: In a placebo-controlled si
Background Pre- and perinatal adversities may increase the risk for schizophrenia and bipolar disorder. Hypoxia-related obstetric complications (OCs) are associated with brain anatomical abnormalities in schizophrenia, but their association with brain anatomy variation in bipolar disorder is unknown. Method Magnetic resonance imaging brain scans, clinical examinations and data from the Medical Bir
Objective. To study degree of blood pressure (BP) control in primary healthcare (PHC) treated hypertensive patients in relation to sex, age, drug treatment, and concomitant diseases. Design. Random sample of patients with hypertension. Setting. Ten PHC centres in the Region of Skane, Sweden. Subjects. All the 30- to 95-year-old patients with hypertension who during the period 12 September to 24 Se
Sporadic mutations in the thrombomodulin (TM) gene occur in patients with both arterial and venous thrombosis, but the effects of these mutations on expression and function are largely unexplored. Full-length wild-type TM complementary DNA (cDNA) was incorporated into vector pcDNA6 for transfection into COS-7 cells for transient expression. Mutagenesis was performed to create 7 TM mutants with nat
OBJECTIVE--To investigate whether a lack of glutathione-S-transferase mu (GSTM1) activity was related to an increased risk for adverse outcome after asbestos exposure. METHODS--A study was made of 78 male former asbestos cement workers, with retrospective cohort data on exposure, radiographical findings, and lung function. Venous blood samples were obtained for the analysis of GSTM1 polymorphism b
Cholesterol-lowering effects of oats have been demonstrated in both animals and human subjects. However, the crucial properties of oat-containing diets that determine their health effects need to be further investigated to optimise their use. A mouse model would be a valuable tool, but few such studies have been published to date. We investigated the effects of oat bran on plasma cholesterol and l
OBJECTIVES: The methyltransferase genotype and pregnancy both influence the arsenic metabolism phenotype, but it is unknown whether these factors interact, explaining the drastic changes in the efficiency of arsenic metabolism observed among pregnant women. The aim of this study was to evaluate the relative contribution of the methyltransferase genotype and pregnancy to the arsenic metabolism phe
Bifidobacterium breve 46, Bifidobacteriumlactis 8:8 and Bifidobacteriumlongum 6:18 and three reference strains B. breve CCUG 24611, B. lactis JCM 10602, and Bifidobacteriumpseudocatenulatum JCM 1200 were examined for acid and bile tolerance, prebiotic utilization and antimicrobial activity against four Clostridium difficile (CD) strains including the hypervirulent strain, PCR ribotype NAP1/027. B.
BACKGROUND AND AIMS: The optimal position for pH electrode placement in the diagnosis of gastroesophageal reflux disease (GERD) is unknown. The aim of this study was to evaluate the discriminatory power of targeted pH recording immediately above the squamocolumnar junction (SCJ) and to compare the results with those obtained by simultaneous recording at the conventional level for pH monitoring. SU
Background: Recombinant factor VIIa (rFVIIa) is used to treat bleeds in hemophilia patients with inhibitors. A subcutaneous formulation could potentially improve its half-life and make it suitable for prophylactic treatment. Objectives: A study was conducted to determine the safety of subcutaneously administered rFVIIa in patients with hemophilia and the pharmacokinetic profile (including bioavail
Byggbranschen står för elva procent av koldioxidutsläppen i världen (WorldGBC, 2019). För att minimera den påverkan måste byggbranschen förbättra byggnaders hållbarhet. Detta skulle kunna göras genom att få en mer exakt förståelse för de laster som påverkar byggnader. En av de laster som påverkar dimensioneringen av byggnader är den nyttiga lasten. Den nyttiga lasten beror på belastningar som uppsThe construction sector stands for eleven percent of the carbon dioxide emissions in the world WorldGBC (2019). To minimize that impact, the construction sector must take a closer look at improving the sustainability of buildings. One way to do this would be to have a more accurate understanding of the loads that affect buildings, including the so-called imposed load. The imposed load includes loa
Cancer cell detection by particle sorting systems is a very challenging field which could help to discover cancers at an earlier stage. Acoustophoresis used as a particle sorting system is based on the difference between the acoustic properties of particles and the medium. Using a standing acoustic wave, the particles with the equivalent acoustic properties are focused at the same point in the cha
This study will show what particular elements, by using a digital tool such as Pluttra, in the practice of conducting pedagogical documentation in the Swedish preschools are profound. By conducting an ethnographic fieldwork and participant observation among the preschool teachers at one preschool, and in-depth interviews with two preschool teachers at another preschool, within the same town. The e
This study compares the two traditional ventilation methods ; mixed ventilation and displacement ventilation, with a new type of dif fuser which attempts to solve the problem with blockage of the diffuser for the displacement ventilation. This new diffuser called Airshower is a product developed by Airson engineering AB whom is also the company where all simulations and tests for this study were
This is a thesis about the Finnish populistic party Perussuomalaiset, in English the Finns Party. The party has become a force to be reckoned within the Finnish politics, therefore, knowing more about the Finns Party members is a must. The aim of the thesis is to map the identities of the Finns Party members and to find out why they chose this particular party. This is interesting because populism
Översvämningshotade byggnader är ett växande problem som uppkommer till följd av havsnivåhöjningen. Problemet är större i södra delar av landet, där många fastigheter riskerar att ta skada eller förstöras till följd av översvämningar. För att förbereda Skåne och Halland för framtiden behövs därför informationen hur havsnivåhöjningen kommer uttrycka sig. Detta projekt fokuserar på att samla, förvalBuildings threatened by folding is an ever-increasing problem due to sea level rise. The problem is greater in the southern parts of Sweden compared to the rest of the country, where a lot of properties are at risk of being destroyed or damaged as a consequence of floods. To prepare Scania and Halland for the future, information about the sea level rise is therefore needed. This project focuses on
As society becomes more ecologically conscious there is a push toward the use of materials with a smaller environmental burden, one of these materials is glulam (GLT), which has gained a lot of traction in recent years not only for ecological reasons but for its ease in manufacture, transport, noise dampening, etc. The focus of this project was to evaluate the influence of different joint configu
