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Effects of inhibitors of small- and intermediate-conductance calcium-activated potassium channels, inwardly-rectifying potassium channels and Na+/K+ ATPase on EDHF relaxations in the rat hepatic artery

1. In the rat hepatic artery, the SK(Ca) inhibitors UCL 1684 (300 nM) completely blocked, and scyllatoxin (1 μM) and d-tubocurarine (100 μM) partially inhibited EDHF relaxations when each of them was combined with charybdotoxin (300 nM). 2. The IK(Ca) inhibitors clotrimazole (3 μM) and 2-chlorophenyl-bisphenyl-methanol (3 μM) strongly depressed EDHF relaxations when each of them was combined with

On the use of coprostanol to identify source of nitrate pollution in groundwater

Investigation of contaminant sources is indispensable for developing effective countermeasures against nitrate (NO3 −) pollution in groundwater. Known major nitrogen (N) sources are chemical fertilizers, livestock waste, and domestic wastewater. In general, scatter diagrams of δ18O and δ15N from NO3 − can be used to identify these pollution sources. However, this method can be difficult to use for

The Impact of Different Drying Techniques and Controlled Storage on the Development of Advanced Glycation End Products in Skim Milk Powders Using Isotope Dilution ESI-LC-MS/MS

The impact of different drying techniques and storage conditions on the formation of carboxymethyl lysine (CML) as an advanced glycation end product (AGE) was investigated in various pilot-scale produced skim milk powders (SMP). CML, an indicator of advanced stages of the Maillard reaction, was analyzed by isotope dilution ESI-LC-MS/MS after drying and at intervals during storage for 200 days. The

Activation of complement by pigment epithelium-derived factor in rheumatoid arthritis

The aim of this study was to identify molecules that trigger complement activation in rheumatic joints. C4d, the final cleavage product of C4 activation, is found in the diseased joint and can bind covalently to complement-activating molecules. By using a highly specific Ab against a cleavage neoepitope in C4d, several molecules that were specifically bound to C4d were identified from pooled synov

Inductive energy transfer

With the diminishing reserves of oil and the growing public concern for environmental issues, the end of gasoline powered vehicles is getting closer each year. To prevent this from causing the personal and comfortable way of transportation mankind has gotten used to, to die with them, an alternative without the downsides of the gasoline engine must be developed. The environmentally friendly electr

Skatterättslig neutralitet mellan olika fastighetstransaktioner – en jämförelse

I denna uppsats kommer det skatterättsliga neutralitetsperspektivet hos fastighetstransaktioner att diskuteras och särskilt fokus kommer att ligga på stämpelskatten. De fastighetstransaktioner som tas upp är överlåtelse, bolagsförvärv och fastighetsbildning. Det moderna svenska skattesystemet bygger på nationalekonomiska teorier och de senaste 30 åren har fokus legat på att få ett effektivt skattIn this essay, the tax neutrality perspective of property transactions will be discussed and a special focus will be put on stamp duty. The real estate transactions which are covered in the essay are transfers, acquisitions and “fastighetsbildning”. The modern Swedish tax system is based on economic theories and in the last 30 years the focus has been put on getting an efficient tax system, wher

Combination of acoustic trapping and impedance spectroscopy for platelet analysis

A combination of acoustic trapping and impedance spectroscopy for micrometer-sized objects is here presented for the first time. Acoustic trapping has proven to be a well-functioning method for non-contact immobilization and positioning of particles or cells in microfluidic channels. The combination with impedance spectroscopy allows for simultaneous electrical measurements on the trapped objects.

Tumour tissue dissociation and acoustophoresis-based cell separation

Ultraljud och mikrochip kan hjälpa oss att förstå cancer bättre En tumör och dess omgivning spelar stor roll i hur cancer utvecklas och genom att förstå vilka celler den består av och sortera ut de viktigaste kan man öka kunskapen om hur cancern bäst ska bekämpas. I detta arbete har immunceller från sådan upplöst bröstvävnad sorteras ut med hjälp av ett mikrochip med små kanaler samt en ultraljudThe aim of this thesis was to compare different ways of dissociating tissue - specifically breast cancer tissue - and sorting out tumour cells and immune cells from the dissociated tissue using acoustophoresis in a microfluidic chip. Due to ethical issues with using tumour tissues to work on the methodology of a project, ultimately only healthy breast tissue was used in this work. Two dissociatio

Millimeter-Wave Radar data processing

Databehandling av signaler från millimetervågsradar i realtid Radarsensorer som använder millimetervågor är väldigt användbara inom avkänningsteknik, som har tillämpningar inom bland annat sjukvården, autonoma robotar, osv. Detta examensarbete bygger vidare på en genomförbarhetsstudie som med positiva resultat undersökte om det var möjligt att med hjälp av elektronik och algoritmer förhindra fallBased on the feasibility study [4], the goal of this master thesis is to compile custom firmware for the XM112 Pulsed Coherent Radar Module, which features a state of the art radar sensor integrated with a microcontroller unit (MCU). This allows the use of custom firmware to check the plausibility of real-time data processing on the radar signals and will lay some of the groundwork for further dev

En jämförelse av fastighetsbolags implementering av Agenda 2030 - med fokus på mål 11

År 2015 antog FN:s länder en agenda för hållbar utveckling som idag kallas för Agenda 2030. Agendan omfattar 17 globala mål samt 169 delmål som skapades för att världen över kunna uppnå en ekonomisk, social samt ekologisk hållbarhet. Dessa mål bygger på millenniemålen där syftet är att slutföra det som inte uppnåddes. Begreppet hållbarhet kan definieras på olika sätt och kan därmed uppfattas olikaIn 2015, the UN countries adopted an agenda for sustainable development, it is today called the 2030 Agenda. The agenda includes 17 global goals and 169 targets that were created to achieve economic, social and ecological sustainability worldwide. These goals are based on the Millennium Development Goals, the purpose of which is to complete what was not achieved. The concept of sustainability can

eBike Radars for Increased Safety

Radar - Dina ögon i nacken när du cyklar Cyklister är en utsatt grupp av trafikanter för olyckor. För att öka säkerheten kan radarteknologi användas för övervakning av döda vinkeln samt ge mervärde till fordonet. Med en enkel notis så kommer man undvika risken med att inte veta vad som kommer bakifrån.The purpose of this thesis is to develop a blind spot detection system for increased safety and comfort for a biker. The solution is based on power-efficient small A111 radars, developed by Acconeer AB, which have a range up to seven meters while consuming only a few milliwatts. Sensor evaluation is performed for the intended use and from this, concepts are generated. These are tested to obtain t

Robusthet och fortskridande ras av 22-våningshus med trästomme

Intresset för att bygga fler och högre trähus i Sverige har senaste tiden ökat bland annat då trä är ett betydligt mer miljövänligt alternativ att bygga med än stål och betong. Stomsystem i trä har dock ingen naturlig sammanhållning likt en platsgjuten betongstomme och därför måste anslutningarna i en trästomme hanteras explicit. RISE (Research Institutes of Sweden) driver en konceptstudie om högaThe interest in building more and higher timber buildings in Sweden has recently increased, for example, because wood is a much more environmentally friendly alternative to construct with then steel and concrete. Frame system in wood has no natural cohesion like a cast concrete frame and therefore the connection in a wooden frame must be managed explicitly. RISE (Research Institutes of Sweden) run

Finns det plats för lek? Samutnyttjande av skolgård och park inom detaljplanelagt område

Det råder idag en trend att förtäta, det vill säga bygga tätt i städer istället för att låta städer växa utåt. Det finns många fördelar med att förtäta då en tät stad ger underlag för bättre service och tätare kollektivtrafik vilket därmed kan leda till mer hållbara städer. Men det finns också nackdelar med att bygga tätt. Genom att förtäta städer samlas fler människor på mindre ytor och därmed ocToday it has become a trend to densify cities instead of allowing them to grow outwards. Densification has many advantages, a dense city provides a basis for better service and denser public transport, which can lead to more sustainable cities. However, building dense also has its disadvantages. By densifying cities, more people gather on a smaller area. This result in more children on a smaller a

Testing the Children: Do Non-Genetic Health-Care Providers Differ in Their Decision to Advise Genetic Presymptomatic Testing on Minors? A Cross-Sectional Study in Five Countries in the European Union

Background: Within Europe many guidelines exist regarding the genetic testing of minors. Predictive and presymptomatic genetic testing of minors is recommended for disorders for which medical intervention/preventive measures exist, and for which early detection improves future medical health. Aim: This study, which is part of the larger 5th EU-framework "genetic education'' (GenEd) study, aimed to

Local environmental governance: Assessing proactive initiatives in building energy efficiency

Popular Abstract in Swedish Städer har kommit att framstå som alltmer drivande i arbetet med att ställa om till ett ekologiskt hållbart samhälle. Utöver att genomföra statliga direktiv eller fokusera på klassiskt kommunala uppgifter som fysisk planering eller renhållning, har kommunala politiker och tjänstemän alltmer kommit att driva en egen miljöpolitik på lokal nivå. Ett exempel är energi- och Local governments are increasingly taking the initiative in environmental governance. But can they make any difference in addressing current environmental challenges, which are becoming more and more global in scope? This PhD thesis explores and analyses the outcomes of proactive initiatives in the field of building energy efficiency, and the governance approaches taken. It addresses outcomes both

Seasonal Variation in Human Salivary Cortisol Concentration

Measurement of cortisol concentration can contribute important information about an individual's ability to adjust to various environmental demands of both physical and psychosocial origin. However, one uncertainty that affects the possibilities of correctly interpreting and designing field studies is the lack of observations of the impact of seasonal changes on cortisol excretion. For this reason

Exposure and toxic effects of elemental mercury in gold-mining activities in Ecuador

Traditional gold mining, using metallic mercury (Hg-0) to form gold amalgam, followed by burning to remove the Hg-0, is widely used in South America, Africa and Asia. The gold is sold to merchants who burn it again to eliminate remaining Hg-0. In Ecuador, 200 gold miners, 37 gold merchants and 72 referents were studied. The median Hg concentrations in urine (U-Hg) were 3.3 (range 0.23-170), 37 (3.

Infromation sharing for improved collaborative planning

Title: Information sharing for improved collaborative planning – A case study in the food supply chain from manufacturer to retail stores Authors: Gunilla Hansson and Maria Hansson, Lund Institute of Technology, Lund University Supervisors: Maria Fagrenius, Customer Service & Development Sweden/Ahold Customer Supply Manager, Kraft Foods Sverige AB Fredrik Nilsson, Department of Design Sciences

Coastal evolution at Macaneta spit, Mozambique - an analysis of longshore and cross-shore processes

Macaneta spit is located about 30km north of Maputo, Mozambique, with the Indian Ocean on the east side and Incomáti River on the west side of the spit, composing an interesting and vulnerable area from a hydrodynamic point of view. Few studies regarding coastal processes are done in the area and changes of the morphology could result in breaching of the spit and thereby affect both accessibility

Evaluation of Steam-Treated Giant Bamboo for Production of Fermentable Sugars

Giant bamboo plantations are currently being established in the Southern Africa region and can be considered as potential lignocellulosic feedstock for the production of second generation bioethanol. In this study, giant bamboo internodal material was subjected to sulphur dioxide (SO2) impregnated steam pretreatment prior to enzymatic hydrolysis. The effect of temperature, residence time, and acid