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BioMed CentralBMC Biotechnology ss Open AcceResearch article Incorporating double copies of a chromatin insulator into lentiviral vectors results in less viral integrants Troels T Nielsen1,2, Johan Jakobsson1, Nina Rosenqvist1 and Cecilia Lundberg*1 Address: 1CNS Gene Therapy Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Sciences, Lund University, BMC A11, S-221 84 Lund,
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Demand-responsive control of electrically heated hot water storage tanks (HWSTs) is one solution, already present in the building stock, to stabilise volatile energy networks and markets. This has been put into sharp focus with the current energy crisis in Europe due to reduced access to natural gas. Furthermore, increasing proportions of intermittent renewable energy will likely add to this volat
Comprehensive approaches to predict performance of wood products are requested by international standards, and the first attempts have been made in the frame of European research projects. However, there is still an imminent need for a methodology to implement the durability and moisture performance of wood in an engineering design method and performance classification system. The aim of this stud
AIMS: To describe the occurrence of psychiatric diagnoses in a specialist care setting in older people with intellectual disability (ID) in relation to those found in the same age group in the general population.METHOD: A cohort of people with ID (n = 7936), aged 55 years or more in 2012, was identified, as was an age and sex-matched cohort from the general population (n = 7936). Information regar
Agricultural intensification and extreme weather events can represent considerable stress to soil microorganisms and their functions by influencing the key players behind the degradation of soil organic matter. A better understanding of the diversity and abundance of microbial functional genes that predict the functional potential of soils, can link the microbial communities to their key ecosystem
The transport of ions related to the penetration of chlorides into concrete has been studied in the field by drilling 100-mm concrete cores from a marine bridge column. A 4-year-old concrete column in Sweden was selected. The concrete was of high quality (i.e., frost- and sulfate-resistant, with a low-heat, low-alkali portland cement with a maximum water-cement ratio of 0.40) according to new Swed
Background: For many children, public playgrounds represent environments that are playful and important in developing good health. Without efforts to facilitate climate change adaptation of outdoor playgrounds there may be a negative impact on children's health and well-being.Aim: With a special focus on play value, to explore the reasoning and described strategies among professionals responsible
In recent years, the need for affordable sustainable housing has increased. At the same time, there has been a gradual rising interest in compact living. With the mounting impacts of climate change, a new way of thinking is needed to develop more resilient and climate responsive ways of living that are compact, affordable, and climate-conscious. In response to this need, the idea of a ‘Z-Free Home
Vertical ground heat exchangers (GHEs) used with ground source heat pump systems have been constructed in a variety of configurations including single U-tubes, double U-tubes, quadruple U-tubes, and coaxial-type. Selections of vertical GHE other than single U-tubes are often motivated by a desire to decrease the borehole thermal resistance and therefore reduce the required amount of drilling and/o
Coastal protection has evolved from focusing on hard solutions such as breakwaters and groynes to include soft or nature-based solutions (NbS). NbS have been pro- posed as cost-effective means to offer long-term coastal protection and at the same time strengthen coastal resilience and biodiversity. However, projects utilizing NbS for coastal protection have often focused on a single solution and t
This paper discusses five major parameters in desalination, namely technology, raw-water, energy sources, cost and environmental effects. Both size and yield have grown rapidly in desalination plants due to high performance in technology developments in the last few years. Five different types of desalination technology are presented and bench-marked for long-term use: multistage flash evaporation
Innovation is an interactive learning process that is facilitated naturally by geographic proximity. Innovation intermediaries can serve as an extra catalyst to and facilitator of interaction and collaboration. With today’s more globalized knowledge and innovation landscape, companies and research organizations seek complementary competencies and partners with whom they can collaborate on a much b
Performance based building (PBB) and design is closely connected to various needs and requirements: Performance levels need to be defined, test methods for verification of performance need to be developed, and reliable performance data are needed for materials, products, constructions, and different design solutions. In contrast to other building materials, PBB and thus service life prediction of
Properties of varved sediments from Lake Logurinn in eastern Iceland and their link to climate and glacial processes of Eyjabakkajokull, an outlet glacier of the Vatnajokull icecap, were examined. A varve chronology, which covers the period AD 1262-2005, was constructed from visual observations, high-resolution images, X-ray density and geochemical properties determined from X-radiography and X-ra
This paper focuses on the use of egress models to assess the optimal strategy in the case of total evacuation in high-rise buildings. The model case study consists of two identical twin towers linked with two sky-bridges at different heights. Each tower is a 50-floor office building. The use of either horizontal or vertical egress components or a combination of them is simulated. The egress compon
Base cation weathering (BCw) rate is one of the most influential yet difficult to estimate parameters in the calculation of critical acid loads of nitrogen (N) and sulfur (S) deposition for terrestrial systems. Only the clay correlation-substrate method, a simple empirical model, has been used for estimating BCw rates for forest ecosystems in the conterminous USA and may not be suitable for applic
Popular Abstract in Swedish Utbredningen av besvär som attribueras till elektrisk utrustning respektive kemikalielukter och andra odörer är ännu ej till fullo fastställd. Vidare saknas kunskap om eventuella bakomliggande faktorer för dessa besvärs uppkomst. Syftet med avhandlingen var att undersöka utbredningen av besvär som attribueras till elektriska faktorer, kemikalier och lukter, samt undersSelf-reported annoyance from electrical equipment has been in evidence since the mid-eighties, and the first reports of illness from everyday chemicals arose already in the 1960?s. However, the extent of the problem or the mechanisms behind the development of environmentally related annoyance has not yet been fully established. Increased vulnerability to stress has been suggested to be a possible
Popular Abstract in Swedish Denna avhandling handlar om en grupp narkotikamissbrukare som gjort självmordsförsök. Såväl självmord som självmordsförsök är betydligt vanligare bland narkotikamissbrukare jämfört med totalbefolkningen. Bland vårdade narkotikamissbrukare är det mellan 19 till 47 procent som gjort självmordsförsök. Det höga självmordsförsökstalet bland narkotikamissbrukare förklaras oftThe aim of this thesis is to describe suicide attempts in a group of drug abusers who previously had received treatment of their addiction. Another aim is to interpret and analyse the life situations that the individual associates with the suicide attempt. The dissertation is based on interviews conducted on two occasions with 92 drug abusers, 62 men and 30 women. The majority of the drug abusers
Enligt lagen (2003:778) om skydd mot olyckor, LSO, har den som äger en byggnad eller bedriver verksamhet i byggnaden det yttersta ansvaret för sitt brandskydd. I skälig omfattning ska det finnas utrustning för livräddning vid brand, och i övrigt ska åtgärder vidtas för att förebygga samt begränsa skador till följd av brand. Det är kommunernas ansvar att utföra tillsyn på brandskyddet så att dettaAccording to Swedish Law (2003:778) on protection against accidents, LSO, the one who owns a building or conducts operations in a building has the ultimate responsibility of their fire protection. To a reasonable extent, there must be equipment for lifesaving in the event of a fire, as well as other measures which must be taken to prevent fire and limit damage as a result of fire. In this study, t
