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Background: Immunohistochemical (IHC) PD-L1 expression is commonly employed as predictive biomarker for checkpoint inhibitors in triple-negative breast cancer (TNBC). However, IHC evaluation methods are non-uniform and further studies are needed to optimize clinical utility. Methods: We compared the concordance, prognostic value and gene expression between PD-L1 IHC expression by SP142 immune cell
While organizations providing critical services to society must have the ability to anticipate and prepare for foreseeable threats, they also need to develop a capacity to adapt in the face of unforeseen challenges and crises. While adaptive capacity becomes manifested in a specific situation through the concrete adaptations carried out by an organization, the preconditions to adapt exist already
Background: Depression and anxiety often reduce people’s ability to cope with everyday occupations. There is a lack of knowledge about such problems in people of working age with depression and anxiety. Aim: To describe which problems people with depression or anxiety disorders experience when performing everyday occupations and which occupations are affected. Materials and methods: Data based on
Critical infrastructure such as transportation, power, telecommunication and water supply systems accommodate and enable flows of essential goods and services that modem societies are highly dependent upon. These critical flows connect countries, organizations and communities, and are imperative for upholding vital societal functions. Disruptions of such flows hold the potential of severe and pote
Proof load testing may be performed to confirm the reliability of the bridge for an existing classification or to prove the reliability for a higher classification.In this paper, a probabilistic decision analysisapproach is applied to the scenario for the evaluation of target proof load in the situation where information on the bridge resistance model is lacking. In this case, the resistance model
We explore peoples' dispositions and practices with regard to social–ecological transformations based on a sustainable welfare policy strategy in Sweden. We draw on Bourdieu's concept of habitus to highlight the relations between social positions, dispositions, and position-takings. Using data from an own survey, we identify habitus types and place these in the space of social positions. We apply
Multi-story apartment buildings, also known as multi-family or multi-unit residential buildings, represent the largest share of newly constructed, residential floor area in Norway, Sweden and Finland. Since the start of 2021, these buildings are required to be nearly-zero-energy under the Energy Performance of Buildings Directive. However, there has been limited research into defining solution-set
The purpose of this conference paper is to showcase how the user experience (UX) methodology of design thinking can facilitate organizational change processes in situations of multiple and often conflicting values and opinions in university libraries. The paper also elaborates on the application of design thinking under both normal circumstances and Covid-19 restrictions. The conference paper is b
Previous research has identified sociodemographic inequalities in fire prevention measures. This study examined whether sociodemographic differences persist in the Swedish population concerning fire prevention measures and particularly whether there remains an inverted u-curve related to age in protection habits. Additionally, it investigated whether fire protection practices are influenced by the
Background: Endocrine disrupting chemicals (EDCs) can cross the placenta and thereby expose the fetus, which may lead to developmental consequences. It is still unclear which chemicals are of concern regarding neurodevelopment and specifically behaviour, when being exposed to a mixture. Objective: The objective is to determine associations between prenatal exposure to EDCs and behavioural difficul
The building sector, as a major consumer of energy and resources, has been slow to adopt sustainability and digitalization compared to other sectors. This dissertation investigates how digital tools, particularly computational design (CD), can support the reuse of building parts within a circular economy framework, through design for disassembly and reuse-centred design (RCD) strategies. The resea
The objectives of this study were to explore active aging among people listed with an interest in relocation, and the relationships between active aging and aspects of perceived home. Using cross-sectional data from the 2022 RELOC-AGE project ( N = 1,509, mean age = 70 years), linear regression analysis was conducted. Women and individuals with higher self-rated health and education reported hig
Mango production plays a vital role in rural livelihoods in Mozambique, yet post-harvest losses remain high, ranging from 25% to over 50%, due to inadequate preservation methods. Improved solar drying technologies offer a sustainable solution by extending shelf life and enhancing product quality. However, their adoption among smallholder mango farmers remains limited. This study investigates the k
Much of the animal ethics and welfare debate today is accused of anthropomorphism, i.e. that human mental states are ascribed to animals. It is generally claimed that these attitudes does no service to animals, since they, according to many natural scientists, usually fail to recognize what animals really are, that animals' needs and responses are actually very different from humans'. The damagin
Could honeybees' most valuable contribution to mankind besides pollination services be alternative tools against infections? Today, due to the emerging antibiotic-resistant pathogens, we are facing a new era of searching for alternative tools against infections. Natural products such as honey have been applied against human's infections for millennia without sufficient scientific evidence. A uniqu
Since 2009, the United Nations Framework Convention on Climate Change (UNFCCC) regime has seen the emergence of several new political groups. This article analyses how the new political groups are positioning themselves in relation to the key UNFCCC principles (the North–South divide and ‘common but differentiated responsibility and respective capabilities’, CBDR/ RC). Drawing on original data, in
Popular Abstract in English Modern society is still largely based on fossil resources. However, there are growing concerns about the security and cost of these resources, as well as climate change resulting from the combustion of fossil fuels. Biofuels represent renewable fuels with the potential to mitigate the adverse effects of fossil fuels, providing a more sustainable alternative. The transpBioethanol from sugarcane is a sustainable alternative to fossil fuels, and the increasing demand for fuel ethanol has prompted studies on the use of the lignocellulosic residues of sugarcane, namely bagasse and leaves, as new feedstock. This thesis describes various process designs and the economic feasibility of producing second generation (2G) ethanol from bagasse and leaves via the enzymatic r
Many of society’s critical infrastructures, such as power supply, telecommunications, and transportation, have become increasingly interconnected. While this gives rise to increased efficiency, tighter connections also invites increased vulnerability and the risks of cascading failures. Moreover, at the same time as many of these vital systems have become increasingly dependent on one another, the
Lead (Pb) is one of the most important models for biomonitoring of exposure, with the blood Pb concentration as a predominant choice in practice and in epidemiology. In this article the alternatives for biomarkers to blood are reviewed. This overview focuses on a number of different qualities that are of importance in the evaluation of a biomarker's usefulness and performance. The qualities scruti
The aim of the present study was to gain information about adrenergic-, cholinergic- and nonadrenergic, non-cholinergic (NANC)- transmitter systems/mediators in the rat vagina, and to characterize its smooth muscles functionally. Tissue sections from vagina of Sprague Dawley rats were immunolabelled with antibodies against protein gene product 9.5 (PGP), synaptophysin (Syn), tyrosine hydroxylase (
