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The immunodeficiency, centromeric region instability, facial anomalies (ICF) syndrome is a rare autosomal recessive disease. Usually, it is caused by mutations in the DNA methyltransferase 3B gene, which result in decreased methylation of satellite DNA in the juxtacentromeric heterochromatin at 1qh, 16qh, and 9qh. Satellite II-rich 1qh and 16qh display high frequencies of abnormalities in mitogen-

Septic tanks with subsequent soil treatment systems (STS) are a common treatment technique for domestic wastewater in rural areas. Phosphorus (P) leakage from such systems may pose a risk to water quality (especially if they are located relatively close to surface waters). In this study, six STS in Sweden (11-28 years old) were examined. Samples taken from the unsaturated subsoil beneath the distr

Acute myeloid leukemia (AML) is a heterogeneous disease of the myeloid lineage. About 35% of AML patients carry an oncogenic FLT3 mutant making FLT3 an attractive target for treatment of AML. Major problems in the development of FLT3 inhibitors include lack of specificity, poor response and development of a resistant phenotype upon treatment. Further understanding of FLT3 signaling and discovery o

Background/Aims: Survival for patients on renal replacement therapy (RRT) has been shown to correlate to the level of physical activity and exercise capacity. We examined whether composite measures of functional status at the start of RRT predict survival. Methods: In this retrospective study, the same physiotherapist, using a standardized battery of tests for functional status, tested 134 patient

We investigated the development of a heterotrophic plankton food web with or without phytoplankton primary production in a long-term (>1 yr) laboratory experiment. Water from 3 Swedish lakes (humic, oligotrophic clearwater, eutrophic) was exposed to low light or kept in total darkness in triplicate 100 1 cylinders. Dissolved organic carbon (DOC) dynamics, bacterial growth and biomass of protozoans

Background: Limited information exists on the framework and content of postgraduate education in internal medicine in Europe. This report describes the results of a survey of postgraduate training in internal medicine in the European countries. Methods: Two online questionnaire-based surveys were carried out by the European Board of Internal Medicine, one on the practice of internists and the othe

"Inflammation resolution" has of late become a topical research area. Activation of resolution phase mechanisms, involving select post-transcriptional regulons, transcription factors, 'autacoids', and cell phenotypes, is now considered to resolve inflammatory diseases. Critical to this discourse on resolution is the elimination of inflammatory cells through apoptosis and phagocytosis. For major in

Background Point-of-care C-reactive protein (POCCRP) is a biomarker of inflammation that offers clinicians a rapid POC test to guide antibiotic prescribing decisions for acute cough and lower respiratory tract infections (LRTI). However, evidence that POCCRP is cost-effective is limited, particularly outside experimental settings. Aim To assess the cost-effectiveness of POCCRP as a diagnostic tool

Modern doubly fed induction generator (DFIG) wind turbines can ride through a symmetrical fault in the network by using a chopper protection on the direct current (DC) link without triggering a crowbar protection. A novel method to model the DC link system of such wind turbines as an equivalent resistance during symmetrical faults is presented in this paper. The method allows looking at the DFIG w

A major limitation to clinical stem cell-mediated gene therapy protocols is the low levels of engraftment by transduced progenitors. We report that CXCR4 overexpression on human CD34(+) progenitors using a lentiviral gene transfer technique helped navigate these cells to the murine bone marrow and spleen in response to stromal-derived factor 1 (SDF-1) signaling. Cells overexpressing CXCR4 exhibite

It is assumed that the Id helix-loop-helix (HLH) proteins act by associating with ubiquitously expressed basic HLH (bHLH) transcription factors, such as E47 and E2-2, which prevents these factors from forming functional hetero- or homodimeric DNA binding complexes. Several tissue-specific bHLH proteins, including HASH-1, dHAND, and HES-1, are important for development of the nervous system. Neurob

Pandemics such as Covid-19 have posed a set of questions concerning safe space usage given the risk of virus transmission in confined and open spaces. In this context, this report presents a risk analysis methodology for the use of crowd modelling tools as an aid to assess safety in confined and open spaces. Crowd models can be used to investigate people movement in the built environment, thus the

A memorable journey to the North – A study of the travel experiences of Chinese tourists in Scandinavia With the increasing number of outbound Chinese tourists, tourism bureaus in Scandinavia are now exploring ways in understanding Chinese tourists as well as to prepare themselves to be more “China-Ready”. The purpose of this thesis is to offer research demonstrating the importance of memory objec

Based on a research project on the refugee reception in Malmö, Sweden in the fall of 2015, this thesis explores how volunteers engaged in refugee related aid work acquire two conflicting identity positions. Through compassionate acts they orient between two poles: the refugees and the Swedish society. Analysis of interviews with volunteers engaged in the refugee reception, as well as observations

Thermal comfort is a topic that for the last century has interested designers and researchers. European and International standards have given guidelines for assessment of thermal comfort in typical indoor environments for long occupancy, however the transitory spaces and semi-external spaces have not been addressed. Available literature was reviewed and summarize to find appropriate methods for a

Today's network cameras are constantly evolving, giving us higher resolution and higher quality video streams which demands higher capacity data links. In Pan, Tilt, Zoom (rotating) cameras the Slip Ring acts as the single communication link between the stationary and rotating parts of the camera and at the same time enables unrestricted rotation. It is therefore a key component within the cam

This thesis covers specification and development of a distributed measurement system intended for CAN bus. It was completed at Scania CV, Södertälje in collaboration with Lund University. The goal of the thesis is to specifiy and develop a distributed measurement system that helps Scania with acquisition of functional and electrical data. Several topics are adressed such as filtering, at what spee

Makten att styra Sverige tillkommer statsråden, vilka utgör regeringen. Regeringsmakten begränsas genom lagbundenhet och funktionsfördelning. Riksdagens funktion är bland annat att kontrollera statsrådens arbete. Statsråden har ett såväl politiskt som rättsligt ansvar inför riksdagen. Uppsatsen utreder ifall regelverket för statsråds rättsliga ansvar för handlande i tjänsteutövningen är tillfredssThe power to govern Sweden belongs to the ministers, who form the government. The governmental powers are limited by law and by distribution of functions. One of the functions of the parliament is to monitor the work of the ministers. The ministers have both a political and a legal responsibility before the parliament. This essay examines whether the legal framework regarding the responsibility th

Decisions made by child welfare workers continue throughout the life of a case. Information is constantly being gathered and coming in from a variety of sources which can complicate the decision-making process. Child welfare agencies can benefit from understanding how child welfare workers make decisions and if certain interventions like the concepts from safety science can help increase the infor