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1Scientific RepoRts | 6:30828 | DOI: 10.1038/srep30828 www.nature.com/scientificreports A Comparison of Rule-based Analysis with Regression Methods in Understanding the Risk Factors for Study Withdrawal in a Pediatric Study Mona Haghighi1, Suzanne Bennett Johnson2, Xiaoning Qian3, Kristian F. Lynch4, Kendra Vehik4, Shuai Huang5 & The TEDDY Study Group† Regression models are extensively used in man

https://www.teddy.lu.se/sites/teddy.lu.se/files/2021-11/61%2010042016_679_61_MP99_Haghighi_SciRep_2016.pdf - 2026-06-23

Microfluidic devices have so far not seen widespread use, even though they could potentially be cheaper, better and faster than traditional methods. A possible reason for this is the lack of a middle step between one-of-a-kind experimental devices and cheap mass produced devices. With ongoing improvements in resolution it is starting to look possible that 3D-printing will fill this role. This the

The ability of the total extract from Physalis angulata; three fractions after partitioning with n-hexane, ethyl acetate (TBE), and water; and four withanolides (compounds 1 – 4) to phosphorylate 5'-adenosine monophosphate-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC) in HepG2 cells was evaluated. The TBE fraction (50 μg/mL) activated p-ACC and p-AMPK expression most strongly. C

With the increasing global awareness about the impacts of climate change on the built environments, the need for improving the climate resilience of buildings is being more acknowledged. Despite the high number of relevant studies, there is a lack of frameworks to assess the resiliency of buildings and urban areas. This study presents a multi-objective framework to optimize the form of buildings a

The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES an

Nickel-based catalysts are the most promising alternative to replace platinum in hydrogen conversion devices in alkaline media. One approach to narrowing the performance gap between Pt and Ni is to fine-tune the nickel surface coverage by (hydr) oxide (NiOxHy) species, which determines its electrocatalytic activity for the hydrogen oxidation (HOR) and hydrogen evolution (HER) reactions. As Ni easi

Parasol is a computer program for calculating the solar and thermal properties of windows with sunshades and the energy demands of a room with a window/shading system. The program has three main features. One of them is a calculation of g, T and U for normal incidence of beam irradiation, which is performed as soon as a window or an internal/interpane sunshade is selected. The other two are based

An efficient technique for enzymatic digestion of proteins in nanovial arrays and identification by peptide mass fingerprinting using matrix-assisted laser desorption/ionization (MALDI-MS) is presented in this work. Through dispensing of a protein solution with simultaneous evaporation the protein (substrate) is concentrated up to 300 times in-vial. At higher substrate concentrations the catalytic

A calorimetric method to determine water activity covering the full range of the water activity scale is presented. A dry stream of nitrogen gas is passed either over the solution whose activity should be determined or left dry before it is saturated by bubbling through water in an isothermal calorimeter. The unknown activity is in principle determined by comparing the thermal power of vaporizatio

BACKGROUND: Seed galactomannans are preferred hydrocolloids since they are comparatively cheap, non-toxic, eco-friendly and non-polluting during production and application. Galactomannans from seeds of three species of Gleditsia, namely G. sinensis, G. microphylla and G. melanacantha, were characterized in terms of structural and thermal properties. RESULTS: Gleditsia polysaccharides were characte

A laboratory study was executed to investigate the effect of surfactants to enhance sorption of polycyclic aromatic hydrocarbon (PAH) contaminants in loess soil. Phenanthrene and naphthalene were chosen as organic contaminant indicators in loess soil modi. fied by the cation surfactant hexadecyltrimethylammonium (HDTMA) bromide. The kinetic behavior of sorption during transport in natural and modi

The structural organization of the gene for the human cysteine-proteinase inhibitor cystatin C was studied. Restriction-endonuclease digests of human genomic DNA hybridized with human cystatin C cDNA and genomic probes produced patterns consistent with a single cystatin C gene and, also, the presence of six closely related sequences in the human genome. A 30 kb restriction map covering the genomic

Background: Poorly differentiated midline carcinoma with a translocation between chromosomes 15 and 19, i.e. t(15; 19), has been recognized as a distinct clinical entity for over a decade. This tumor affects young individuals, shows a rapidly fatal clinical course despite intensive therapy. The t( 15; 19) results in the fusion oncogene BRD4-NUT. Information concerning treatment of this rare disord

Phosphatidylethanol is formed by phospholipase D in animal cells exposed to ethanol. Previous reports have demonstrated that the degradation of phosphatidylethanol is slow, indicating that this lipid may be present in the cells after ethanol itself has disappeared. Accumulation of an abnormal alcohol metabolite may influence cellular functions. In the present study, cultivation of NG108-15 neurobl

Lung cancer is a common cause of cancer mortality in the world, largely due to the risk factor of tobacco smoking. The drug therapy at the molecular level includes targeting the epidermal growth factor receptor (EGFR) tyrosine kinase activity by using inhibitors, such as erlotinib (Tarceva) and gefitinib (Iressa). The heterogeneity of disease phenotypes and the somatic mutations presented in patie

A major bottleneck in high-throughput protein production is the validation step, which is why parallel and automated sample processing methods are highly desirable. Also, a miniaturized sample preparation format is preferred, as the reduction of reagent volumes significantly decreases the analysis cost per sample. We have developed an automated and miniaturized protein sequence verification protoc

The concentration of soluble HLA class I (sHLA-I) was measured by ELISA in serum samples from 30 well-characterised SLE patients at high and low disease activity states and from 100 healthy controls. HLA-A allotypes in the patients were analysed by a PCR-based typing technique. A higher level of sHLA-I was found in SLE patient sera both at high and low disease activity than in controls (P< 0.001).

The authors evaluated physiologic, psychologic and metabolic effects of a nine-week in-hospital training program on 14 men with severe disabling angina pectoris. The exercise program consisted of intensive interval training on an ergometer bicycle for two 30 min sessions daily. The physical performance increased by about 40% (p less than 0.001). Plasma insulin levels were reduced and glucose toler

Bone disease is an important feature of multiple myeloma, and hypercalcaemia is a frequent complication of this disease. We examined the association between serum calcium and quality of life (QOL) scores of 686 multiple myeloma patients at the time of diagnosis. Data from two Nordic studies using the EORTC QLQ-C30 questionnaire were analysed by means of linear regression analysis and a curve fitti

Speed and accuracy are crucial prerequisites in the application of proteomic methods to clinical medicine. We describe a microfluidic-based nanovial array for rapid proteolytic processing linked to MALDI-TOF MS. This microscale format consumes only minute amounts of sample, and it is compatible with rapid bioanalytical protocols and high-sensitivity readouts. Arrays of vials (300 mu m in diameter