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Spondyloarthritis (SpA) is a group of interrelated inflammatory rheumatic diseases with the sub-diagnoses ankylosing spondylitis (AS), psoriatic arthritis (PsA), arthritis-associated inflammatory bowel disease (Aa-IBD), undifferentiated SpA (USpA), where stiffness and pain are key symptoms. Insidious onset back pain, morning stiffness, waking up at night, and improvement from exercise are common c
Objective . To evaluate the clinical performance in a paediatric population of the Lund-Malmo creatinine-based glomerular filtration rate (GFR) prediction equations, primarily developed for adults. Material and methods . Iohexol clearance was used as the gold standard in 85 paediatric Caucasian patients (0.3-17 years; 37 F/48 M). One Lund-Malmo equation was based on age and gender (LM) and one inc
Popular Abstract in Swedish Men älskar du honom? Så frågar en ung flicka på 1820-talet sin syster Henrietta som just skall gifta sig. Nej det gör Henrietta inte men hon böjer sig för den krassa verkligheten, behovet att bli försörjd. Den stillsamma frågan anger något som kan tolkas som en tyst revolution: övergången från en äldre syn på äktenskapet som ett ekonomiskt kontrakt till en uppfattning aThe main theme of this dissertation is the question of how young women in the early middle class handled the new demands for marriage based on love instead of on judgements of moral, economy and status. Another theme is the education of these middle class girls around 1800 and the question how this new education interacted with the new demands for love marriage. The German social historian Ulrike
Popular Abstract in Swedish Små partiklar i form av vätska eller fast material mellan 0.001 till 100 µm i diameter, kan sväva i luften och kallas då aerosolpartiklar. De påverkar direkt på klimatet genom att reflektera solstrålar ut till rymden. Detta gör att vi får ett kallare klimat. Indirekt kan de påverka klimatet genom att verka som kondensationskärnor vid molnbildning. Med detta påverkar de The aim of this work was to study atmospheric aerosols, focusing on the chemical composition, the morphology and the origin of the aerosol in the upper troposphere and lowermost stratosphere. An aerosol sampler was developed for this purpose. A new method for quantitative analysis of the major components of the aerosol, i.e. C, N and O was developed, and methodologies for single-particle analysis
Popular Abstract in Swedish Denna avhandling handlar om energieffektiva fönstersystem i svenska byggnader. Simuleringar av energianvändningen har gjorts för både småhus och kontor för att bedöma effekterna av olika fönsterval på energibehov och inneklimat. Två års mätningar av energianvändning och innetemperaturer för ett energisnålt radhus har utvärderats. Två beteendestudier har även genomförts This thesis deals with energy-efficient windows in Swedish buildings. Parametric studies were performed in the dynamic energy simulation tool Derob-LTH in order to study the effects of window choices on energy use and indoor climate for both residential and office buildings. A steady-state program was used to evaluate two years of measurements of energy use and indoor temperatures of an energy-eff
The fire technical properties of products are determining factors for the initiation and growth of fires. Measurement of fire technical properties and the understanding of how they relate to real hazards are therefore important for fire safety. This work deals with the fire technical properties of building products, their tendency to ignite and release heat in different fire scenarios. Building p
Navigation is the ability of animals to move through their environment in a planned manner. Different from directed but reflex-driven movements, it involves the comparison of the animal’s current heading with its intended heading (i.e., the goal direction). When the two angles don’t match, a compensatory steering movement must be initiated. This basic scenario can be described as an elementary nav
Background: The loss of carbon (C) from agricultural soils has been, in part, attributed to tillage, a common practice providing a number of benefits to farmers. The promotion of less intensive tillage practices and no tillage (NT) (the absence of mechanical soil disturbance) aims to mitigate negative impacts on soil quality and to preserve soil organic carbon (SOC). Several reviews and meta-analy
Most studies that validate GFR equations present accuracy results stratified by measured GFR (mGFR; diagnostic correctness) or by estimated GFR (eGFR; diagnostic predictiveness) only, without a clear distinction in interpretation. The accuracy of a GFR equation is normally reported in percent (e.g. P30), but is often misinterpreted when stratified by eGFR. The aim of the study was to develop new a
BACKGROUND: The Eight-Twenty-One (ETO) nuclear co-repressor gene belongs to the ETO homologue family also containing Myeloid Translocation Gene on chromosome 16 (MTG16) and myeloid translocation Gene-Related protein 1 (MTGR1). By chromosomal translocations ETO and MTG16 become parts of fusion proteins characteristic of morphological variants of acute myeloid leukemia. Normal functions of ETO homol
Background: Many women of childbearing age are occupationally active, which leads to a large number of pregnancies potentially exposed to occupational exposures. Occupational noise has been identified as a risk factor for hearing impairment in adults. However, very few studies have assessed the effect of occupational noise on the fetus. Objectives: The aim of this study was to investigate whether
As observed in earlier studies, there is evidently a performance gap between the predicted annual energy use from building performance simulations basedon traditional deterministic methods compared to the monitored annual energy use of a building. The hypothesis is that using a probabilistic method makes it possible to consider the uncertainties in the input data and quantify the overall uncertainAs observed in earlier studies, there is evidently a performance gap between the predicted annual energy use from building performance simulations based on traditional deterministic methods compared to the monitored annual energy use of a building. The hypothesis is that using a probabilistic method makes it possible to consider the uncertainties in the input data and quantify the overall uncertai
One of the basic principles of Swedish law is that everyone is entitled to have his/her claims determined by a court and that the judgment should be given after a hearing. The main rule is that the plaintiff can claim whatever he/she wants, even if it seems absurd. This is a right also given by the European Convention of the human rights article 6:1, which says that everyone is entitled to a publi
Popular Abstract in Swedish Diffust storcelligt B-celllymfom (DLBCL) är den vanligaste aggressiva lymfomsjukdomen, och drabbar ca 450 personer årligen i Sverige. Med modern antracyklin-innehållande cytostatikabehandling är DLBCL en potentiellt botbar sjukdom. Av patienter med lokaliserad sjukdom botas 70 %, med spridd sjukdom ca 50 %. Bakgrunden till arbete 1 i denna avhandling var en rapport därDiffuse large B-cell lymphoma (DLBCL) is the most frequent lymphoma subtype. In Sweden 450 new cases are diagnosed annually. With modern anthracycline-containing chemotherapy DLBCL is potentially curable, with an estimated overall cure rate of approximately 50% for patients with advanced stage disease. Through molecular profiling of DLBCL the ?cell-of-origin concept? has been established: patients
De flesta makar och sambor bor tillsammans i en fastighet eller i en lägenhet som de vanligtvis betraktar som deras gemensamma bostad. Inte ovanligt är att fastigheten utgör en lantbruksfastighet eller att någon av parterna bedriver näringsverksamhet i bostaden. För makar och sambor finns i äktenskapsbalken respektive sambolagen ett par skydds¬regler som kan bli tillämpliga vid en separation mellaThe majority of married couples and co-habitants live together in rented or owned accommodation which they usually consider to be their joint property. It is not unusual that the property is an agricultural property or that one half of the couple use the property for business purposes. There are protective provisions in The Marriage Code and also in The Cohabitees Act which are relevant in case of
In conventional design of pile foundations, all loads are taken by the piles, i.e. the contact pressure between the raft and the soil is neglected. In the last decades geotechnical engineers have started to take this pressure into account in design of pile foundation. Such a foundation, where the raft and the piles interact to transfer the loads to the ground, is in this dissertation called piled
Popular Abstract in Swedish Vi är under ständig attack från mikroorganismer som vill leva på oss och i oss. Vissa av dessa är vanligtvis nyttiga medan andra är sjukdomsframkallande. Kroppens försvar mot invaderande organismer består av många delar. Ytterst sitter huden som en mekanisk barriär, vi har slem och epitelceller i luftvägar och magtarmkanal samt skyddande ämnen i exempelvis tårvätska. I Transplantation antigens encoded in the major histocompatibility complex (MHC) bind peptides and present them to T cells. We showed that mouse T cells expressing transgenic human CD8 can recognise human MHC class I. Expression on mature T cells is sufficient for activation in a mixed lymphocyte culture but expression both on thymocytes and mature T cells is necessary for peptide specific MHC restr
Background: To examine rates of serious pneumococcal infections up to 10 years after vaccination with 7-valent conjugated pneumococcal vaccine (PCV7) in patients with arthritis compared to non-vaccinated arthritis patients.Methods: In total, 595 adult arthritis patients (rheumatoid arthritis; RA = 342, 80 % women and spondylarthropathy; SpA = 253, 45 % women) received one dose of PCV7. Mean age/di
AIM: To describe sociodemographic disparities in temporal trends of incidence and age distributions of first registered osteoarthritis (OA) diagnosis in southern Sweden.METHODS: We identified all Skåne residents aged 35+ who had lived in the region at any point during the period 2006-2019 with no previous OA diagnosis (ICD-10 codes M15-M19) for 8 years prior to inclusion in the study (n = 849,061)
Introduction: With over 360 blood group antigens in systems recognized, there are antigens, such as RhD, which demonstrate a quantitative reduction in antigen expression due to nucleotide variants in the non-coding region of the gene that result in aberrant splicing or a regulatory mechanism. This study aimed to evaluate bioinformatically predicted GATA1-binding regulatory motifs in the RHD gene f
