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A quite common view is that the scientific persona matters less in contemporary Western knowledge societies. Large research groups produce new scientific discoveries gathered around impersonal expert system. However, it is also well known that scientific cultures differ widely. In physics, the projects are quite impersonal, sometimes including thousands of persons. The prime example is the CERN or
As the contribution of dispersed or distributed energy resources (DER) to the electric power production increases, the effects on the power system grow more important. As an example a critical situation may arise if protective relays trip a large part of the dispersed generation due to undervoltage at a short-circuit event. On the other hand it is crucial that the protection system acts correctly
Objective. Infliximab, an anti-tumor necrosis factor alpha (anti-TNF alpha) antibody, is effective in the treatment of several immunoinflammatory diseases. However, many patients experience primary or secondary response failure, suggesting that individualization of treatment regimens may be beneficial. This study was undertaken to investigate whether serologic monitoring of infliximab bioavailabil
Combustion of hydrocarbons in under-ventilated conditions has been studied experimentally and simulated with the CFD-code SOFIE. This report covers the experimental study in a 1/3 scale model of the ISO room corner test (ISO) 9705). The CFD-simulation part of the project has been published earlier in a SP-Report 1996:41 “CFD Modelling if under-ventilated Fires” by Heimo Touvinen and presented at t
Background: Laser photocoagulation is a well-established treatment for diabetic retinopathy but the mechanism behind its effectiveness has not been elucidated. The protein kinase C (PKC) family is a group of enzymes which has been the subject of extensive interest in clinically related research since the advent of its role in the pathogenesis of diabetic retinopathy. With this study we wanted to e
Popular Abstract in Swedish Sjukdomen ärftlig hjärnblödning med cystatin C-amyloid angiopati (engelsk förkortning, HCCAA) beror på att en ärftlig mutation i genomet förändrar en byggsten (aminosyra) i proteinet cystatin C. Cystatin C-varianten som uppkommer deponeras som olösligt material (amyloid) i blodkärlens väggar och leder till att dessa ofta brister före 40-årsåldern med hjärnblödning som fHereditary cystatin C amyloid angiopathy (HCCAA) is a disorder characterised by multiple strokes in young adults, resulting in paralysis and dementia. The disease is caused by a mutation in the gene coding for the peptidase inhibitor cystatin C. The mutation causes an amino acid substitution Leu68 -> Gln in cystatin C (L68Q cystatin C) which results in deposition of the protein in the blood vessel
The time that it takes an occupant population to reach safety when descending a stair during building evacuations is typically estimated by measureable engineering variables such as stair geometry, speed, stair density, and pre-observation delay. In turn, engineering models of building evacuation use these variables to predict the performance of egress systems for building design, emergency planni
Manager och Civil Servant är en utforskning av aktörers förgivet tagna antaganden vilka styr uppfattningar kring hur offentlig förvaltning ska ske i samtida välfärdsstater. Det hävdas att mer än 30 år av pågående och riktade reformer gentemot den offentliga förvaltningen har orsakat dilemman att uppstå. Dessa dilemman har resulterat i en förskjutning av balansen kring några fundamentala pelare inoManager and Civil Servant is an exploration of actors’ taken-for-granted assumptions that govern perceptions concerning how public administration should be undertaken within contemporary welfare states. It is argued that more than 30 years of continuous reforms directed towards public administration have caused dilemmas to arise. These dilemmas have resulted in a shifting of balances regarding the
Background: Health-related quality of life (HRQoL) was a secondary end point in AGO-OVAR 16, which randomized 940 patients with EOC after first-line chemotherapy to maintenance pazopanib (PZ) or placebo (P). Additional post hoc analyses were carried out to investigate additional patient-centered end points. Patients and methods: HRQoL was measured with EORTC-QLQ-C30, QLQ-OV28 and EQ-5D-3L. Pre-spe
Over the last 15 years significant advancements in induced polarization (IP) research have taken place, particularly with respect to spectral IP (SIP), concerning the understanding of the mechanisms of the IP phenomenon, the conduction of accurate and broadband laboratory measurements, the modelling and inversion of IF data for imaging purposes and the increasing application of the method in near-
Objectives: To examine the risk of putative pneumococcal infections in adult arthritis patients on different anti-rheumatic drugs immunized with heptavalent pneumococcal conjugate vaccine (Prevenar 7; PCV7) and non-vaccinated individually matched arthritis patients. Method: All individuals in a cohort of 505 patients with rheumatoid arthritis (RA) or spondylarthropathy (SpA) receiving different an
Objectives: Improved prediction modeling in osteoarthritis (OA) may encourage risk reduction through calculation of individual and population lifetime risks. There are currently no prediction models for hand OA. Thus, we aimed to 1) develop a prediction model for hand OA in men and 2) to contrast its discriminative performance to a prediction model for lung cancer and chronic obstructive pulmonary
The cysteine proteases are enzymes found in every kingdom of life. Clan CA is the largest of the cysteine protease clans, with members all displaying a Cys/His/Asn(Asp) catalytic triad responsible for hydrolysing the peptide bond within the substrate. To regulate the activity of the proteases, another group of proteins act as natural inhibitors (cysteine protease inhibitors) and bind to the protea
Background: Achlorhydria caused by e.g. atrophic gastritis allows for bacterial overgrowth, which induces chronic inflammation and damage to the mucosal cells of infected individuals driving gastric malignancies and cancer. Enterococcus faecalis (E. faecalis) can colonize achlohydric stomachs and we therefore wanted to study the impact of E. faecalis infection on inflammatory response, reactive ox
I Sverige har under de senaste åren ungefär 19 000 barn under 15 år årligen misstänkts för att ha begått ett brott. Det finns dock ingen bra samlad statistik då barn under 15 år inte kan lagföras för brottet. När ett barn misstänks för ett brott har polisen en anmälningsplikt till socialtjänsten. Om det begångna brottet har minst ett års fängelse i straffskalan eller om socialtjänsten begär det skDuring the last few years approximately 19 000 children below the age of 15 have been suspected for committing an offence. However there is no comprehensive statistics when children below the age of 15 cannot be charged for the offence. The police must report all children who are suspected for committing a crime to the local social services. If the minimum sentence for the committed crime is one y
Detta examensarbete var en del i ett forskningsprojekt som utfördes vid avdelningen för maskinkonstruktion vid Lunds tekniska högskola och gick ut på att studera hur metodiken kring produktutveckling används hos ett antal företag i praktiken och jämföra detta med metodiken från litteraturen och det som lärs ut vid Lunds tekniska högskola, för att identifiera brister i modellerna och fungera som etThis Master´s Thesis is part of a larger research project carried out at the Division of Machine Design, Department of Design Science, LTH, and is about studying the product development methodologies applied in the industry and compare these to the methodologies described in the literature and taught at LTH. The first part of the assignment consisted in studying the existing methodologies about pr
Three speakers engaged with theatre in different ways (professor, director, actor, lecturer, philosopher) got inspired by the dialogical structure of Brecht’s Buying Brass and staged a similarly structured conversation. This conversation imitated the way how thespians and intellectual met in Brecht’s original text, but it was thematically focused on the current socio-cultural context. The research
OBJECTIVES: Evidence on waning patterns in protection from vaccine-induced, infection-induced, and hybrid immunity against death is scarce. The aim of this study is to assess the temporal trends in protection against mortality.METHODS: Population-based case-control study nested in the total population of Scania Region, Sweden using individual-level registry data of COVID-19-related deaths (<30 day
Background: Leakage of fire-fighting foam from an airfield caused contamination of the drinking water supplied to a third of the population in Ronneby, resulting in very high serum levels of predominantly perfluorooctane sulfonate (PFOS) and perfluorohexane sulfonate (PFHxS). The results of studies investigating the association between exposure to perfluorinated alkyl substances (PFAS) and pregnan
Objective: To investigate whether the Multi-Biomarker Disease Activity (MBDA) score predicts optimal add-on treatment in patients with early rheumatoid arthritis (RA) who were inadequate responders to MTX (MTX-IRs). Methods: We analyzed data from 157 MTX-IRs (with a Disease Activity Score using the erythrocyte sedimentation rate [DAS28-ESR] >3.2) from the Swedish Pharmacotherapy (SWEFOT) trial who
