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A Zn(Cys)4 center has been found in the C-terminal region of the crystal structure of the anaerobic class III ribonucleotide reductase (RNR) from bacteriophage T4. The metal center is structurally related to the zinc ribbon motif and to rubredoxin and rubrerythrin. Mutant enzymes of the homologous RNR from Escherichia coli, in which the coordinating cysteines, conserved in almost all known class I
Activated coagulation factor V functions as a cofactor to factor Xa in the conversion of prothrombin to thrombin. Based on introduction of extra carbohydrate side chains in recombinant factor V, we recently proposed several regions in factor Va to be important for factor Xa binding. To further define which residues are important for factor Xa binding, we prepared fifteen recombinant factor V varia
In this study, we show a significantly reduced assay time and a greatly increased bead recovery for a commercial Luminex-based multiplex diagnostic immunoassay by performing all liquid handling steps of the assay protocol in a non-contact acoustic trapping platform. The Luminex assay is designed for detecting antibodies in poultry serum for infectious bursal disease virus, infectious bronchitis vi
Tertiary lymphoid structures (TLS) in the tumor microenvironment are prognostically beneficial in many solid cancer types. Reports on TLS in high-grade serous tubo-ovarian carcinoma (HGSC) are few, and the prognostic impact is unclear. We investigated mature TLS (mTLS), immature TLS (iTLS) and lymphoid aggregates (LA) in primary adnexal tumors (PTs) and synchronous omental/peritoneal metastases (p
Il était une fois deux amis qui voulait partir en vacance en Italie. Autour d'une tasse de tea les deux amie réflechissaient à leur voyage et rêvaient déjà de leurs vacances. L'une rêvait de bronzer au soleil tandis que l'autre pensait plutôt au rencontre qu'elle allait faire. Au moment du départ, après avoir étudié la carte, elle s'apercurent que leurs valises ne tenaient pas dans le coffre de le
In Burkina Faso, the recent emergence of the “koglweogo” vigilante groups is often explained as a result of a “security vacuum.” This explanation, however, tends to depoliticize the power relations that underlie the phenomenon of vigilantism. In this article we analyze the justifications for the emergence and work of koglweogo groups and for the national policy of community-based policing that aim
A welfare state consists of a variety of client organisations withinwhich, among other professions, academics and social workers areactive. Social work as a profession has developed in a welfare contextwhere changes at the different levels of the individual, organisationand society constantly pose new challenges to the profession.When a society undergoes a total transformation, this also affectshi
OBJECTIVE: To investigate the possible role of FCGR2A 519A>G and FCGR3A 559A>C functional polymorphisms in the genetic predisposition to susceptibility to systemic sclerosis (SSc) or clinical phenotype. METHODS: A total of 1566 patients with SSc and 2271 geographically matched controls were included in our study. We analyzed the genotype and allele frequencies of the FCGR2A 519A>G and FCGR3A 559A>
