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OBJECTIVE: In observational epidemiologic studies, higher plasma high-density lipoprotein cholesterol (HDL-C) has been associated with increased risk of intracerebral hemorrhage (ICH). DNA sequence variants that decrease cholesteryl ester transfer protein (CETP) gene activity increase plasma HDL-C; as such, medicines that inhibit CETP and raise HDL-C are in clinical development. Here, we test the
Metal-halide perovskite semiconductors are certainly one of the hottest topic in solar energy conversion. Optimization of both the absorber material and device architecture has led to an astoundingly rapid increase in the reported device efficiencies. Initially developed in the context of dye-sensitized solar cell research, metal-halide perovskite devices now reach efficiency values and hence need
Things are seldom ideal. The quality in information underlying the assessment of risk and support decisions is not an exception. Quantitative measures of uncertainty are extremely useful, but a problem with quantitative measures of uncertainty is that qualitative aspects of uncertainty, e.g. related to weaknesses in background knowledge or deep uncertainty (Cox 2012), are difficult to address.
Introduction: The cesarean rates are low but increasing in most Nordic countries. Using the Robson classification, we analyzed which obstetric groups have contributed to the changes in the cesarean rates. Material and methods: Retrospective population-based registry study including all deliveries (3 398 586) between 2000 and 2011 in Denmark, Finland, Iceland, Norway and Sweden. The Robson group di
Purpose: A degenerative meniscus lesion is a slowly developing process typically involving a horizontal cleavage in a middle-aged or older person. When the knee is symptomatic, arthroscopic partial meniscectomy has been practised for a long time with many case series reporting improved patient outcomes. Since 2002, several randomised clinical trials demonstrated no additional benefit of arthroscop
The effect of the buffer formulation in terms of buffer identity and ionic strength on the interaction between chicken egg lysozyme and carboxyl-modified polystyrene nanoparticles has been systematically studied. The time evolution of the fluorescence of a reporter molecule shows that lysozyme interacts with the nanoparticles in all the studied conditions. The interaction results in changes in pro
Aims: The aim of this study was to investigate the associations between socioeconomic status (SES) and self-reported unmet health care needs, taking economic stress, generalized trust in other people and trust in the health care system into account. Methods: The 2012 public health survey in Scania was conducted using a postal questionnaire and included 28,029 participants aged 18-80 years. The stu
The structure and dynamics of nanostructure films formed by mixtures of soy phosphatidylcholine and glycerol dioleate at the silicon-aqueous interface were studied by grazing incidence neutron spin echo spectroscopy (GINSES), specular and off-specular neutron reflectometry, and small-angle X-ray diffraction. Reverse hexagonal (HII) and micellar cubic phase (Fd3m) layers at the solid-liquid interfa
Background and aim Pain is common and adds to the global burden of disease. However, individuals suffering from pain are a heterogeneous group in terms of pain spreading, intensity and duration. While pain influences overall health care consultation not everyone with pain consult health care. To be able to provide health care matching the patients’ needs increased knowledge about what factors dete
Objective: Prospectively monitor how treatment of acutely ruptured anterior cruciate ligament (ACL) affects biomarkers of inflammation and proteolytic degradation over 5 years. Design: We studied 119 subjects with acute ACL injury from the randomized controlled knee anterior cruciate ligament, non-surgical versus surgical treatment (KANON)-trial (Clinical trial ISRCTN 84752559) who had synovial fl
Biological membranes do not only occur as planar bilayer structures, but depending on the lipid composition, can also curve into intriguing threedimensional structures. In order to fully understand the biological implications as well as to reveal the full potential for applications, e.g. for drug delivery and other biomedical devices, of such structures, well-defined model systems are required. He
We show theoretically that a thermoelectric heat engine, operating exclusively due to quantum-mechanical interference, can reach optimal linear-response performance. A chiral edge state implementation of a close-to-optimal heat engine is proposed in an electronic Mach-Zehnder interferometer with a mesoscopic capacitor coupled to one arm. We demonstrate that the maximum power and corresponding effi
The concept of evaporation driven self-assembly of nanoparticles is exploited to fabricate three dimensional microstructures on textured superhydrophobic surfaces. The evaporative droplets always remain in Cassie–Baxter state during the process of drying. However, the wetting transition from Cassie to Wenzel state has been observed for pure water drop on similar surfaces. After complete evaporatio
Background: A hallmark of osteoarthritis is increased proteolytic cleavage of aggrecan. Cross talk between cartilage and the synovium + joint capsule (SJC) can drive cartilage degradation by activating proteases in both tissues. We investigated aggrecan proteolysis patterns in cartilage explants using a physiologically relevant explant model of joint injury combining cartilage mechanical compressi
We present a framework to segregate the roles of elastic and non-elastic deformations in the examination of real-space experiments of solid-solid Martensitic transitions. The Martensitic transformation of a body-centred-tetragonal (BCT) to a body-centred-orthorhombic (BCO) crystal structure has been studied in a model system of micron-scale ionic microgel colloids (P. S. Mohanty, P. Bagheri, S. Nö
Background and purpose — Analysis of the revision-free survival of knee and hip prostheses has traditionally been performed using Kaplan–Meier analysis and Cox regression. The competing risk problem that is related to patients who die during follow-up has recently been increasingly discussed, not least with regard to the problem of choosing a suitable statistical method for the analysis. We compar
