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Aim To examine the associations between individual- and disease-related factors and the odds of reaching a clinically relevant pain reduction in people with knee and/or hip osteoarthritis (OA) who underwent a first-line self-management program. Materials and methods An observational registry-based study including people with knee (n = 18,871) and hip (n = 7,767) OA who participated in a self-manag
Background: To maintain a low incidence of Catheter Related Infections (CRI) and Catheter Related Bloodstream Infections (CRBSI), continuous follow-up studies on catheter management are necessary. The aims of the present study were to investigate the incidence of catheter tip colonisation, CRI and CRBSI in the Region, to further explore the feasibility of automatic data collection and to investiga
The Antikythera Wreck represents a unique example of implementation and development of technological methods and systems aiding archaeological research. Since 1900, when the wreck was discovered, the challenges posed by the underwater environment and the variety of archaeological data hidden in the multifarious artifacts has been yielding great opportunities for technological innovation. Research
By 2050, seven billion people will be living in cities. In 2020 itself, these cities dumped a whopping 29 trillion tonnes of carbon dioxide into the atmosphere. This carbon dioxide along with other greenhouse gases poses a serious health hazard. It also manifests as extreme weather events, leading to the loss of lives, livelihoods, assets, and social wellbeing.Given the significant impact that cit
A search for a narrow scalar resonance decaying into an opposite-sign muon pair produced in events with and without b-tagged jets is presented in this paper. The search uses 36.1 fb−1 of s=13 TeV proton-proton collision data recorded by the ATLAS experiment at the LHC. No significant excess of events above the expected Standard Model background is observed in the investigated mass range of 0.2 to
BACKGROUND: The dual-mobility acetabular cup (DMC) has an additional bearing consisting of a mobile polyethylene component between the prosthetic head and the outer metal shell. This design has gained popularity in revision total hip arthroplasty (THA) and in primary treatment of femoral neck fractures with the anticipation of a reduced risk of THA instability. Our primary aim was to evaluate the
Urethral obstruction in cats is an emergency that without adequate intervention may progress to uremia and death of the patient. Prolonged distension of the bladder will result in loss of contractile function and consequently, bladderatonia and this can become permanent. It is concluded that the pre-pubic urethrostomy in feline is effective for correction of urethral stenosis even afte previous pe
Background: The Bethesda system for cytopathology (TBSRTC) is a 6-tier diagnostic framework developed to standardize thyroid cytopathology reporting. The aim of this study was to determine the risk of malignancy (ROM) for each Bethesda category. Methods: Thyroidectomy-related data from 314 facilities in 22 countries were entered into the following outcome registries: CESQIP (North America), Eurocr
BACKGROUND: Given today's high prevalence of common mental disorders and related sick leave among teachers, an urgent need exists for a more systematic approach to the management of social and organizational risk factors within schools. In 2015, we launched the first Swedish occupational health guideline to support a structured prevention of these risks at the workplace. The existence of guideline
BACKGROUND: The diagnosis of bone mineral density (BMD) abnormalities involves dual-energy x-ray absorptiometry (DXA), but few patients complete this after a fragility fracture. The assessment of BMD using Hounsfield unit (HU) measurements from computed tomography (CT) scans has been correlated with DXA results in previous studies. We aimed to evaluate the correlation between shoulder CT HU and DX
Notch wear often determines tool life when machining stainless steel. Chemical Vapour Deposited (CVD) Al2O3/Ti(C,N) coated cemented carbide tools are the first recommendation for turning of stainless steel. The CVD coating plays a vital role in reducing and delaying tool wear progress. Hence, it is essential to understand the interaction between the initiation of notch wear and the coating degrada
In stainless steel turning, cutting tool life is often limited by excessive localised damage at the depth of cut line, known as notch wear. Previous research revealed that notch wear in CVD (chemical vapour deposition) Al2O3/Ti(C,N) coated WC-Co tools begins as a coating brittle fracture already after 0.3 m of cutting. This paper investigates the impact of cutting tools and workpiece materials on
Evolvability is the capacity of a population to generate heritable variation that can be acted upon by natural selection. This ability influences the adaptations and fitness of individual organisms. By viewing this capacity as a trait, evolvability is subject to natural selection and thus plays a critical role in eco-evolutionary dynamics. Understanding this role provides insight into how species
A search for light long-lived neutral particles with masses in the O(MeV–GeV) range is presented. The analysis targets the production of long-lived dark photons in the decay of a Higgs boson produced via gluon–gluon fusion or in association with a W boson. Events that contain displaced collimated Standard Model fermions reconstructed in the calorimeter or muon spectrometer are selected in 139 fb−1
Background: The global incidence of stroke is on the rise, primarily due to an increase in the aging population and the prevalence of vascular risk factors among the elderly. However, stroke is a treatable condition if promptly recognized and managed effectively. To optimize stroke management, it is crucial to establish a well-prepared infrastructure comprising adequately trained physicians workin
In this didactic paper, we present a theoretical modeling framework, called the G-function, that integrates both the ecology and evolution of cancer to understand oncogenesis. The G-function has been used in evolutionary ecology, but has not been widely applied to problems in cancer. Here, we build the G-function framework from fundamental Darwinian principles and discuss how cancer can be seen th
The high-prevalence blood group antigen, Sda, had been puzzling blood bankers and transfusionists for at least a decade when it was reported in 1967. The characteristic mix of agglutinates and free red blood cells (RBCs), caused by anti-Sda, is seen with the RBCs from 90 percent of individuals of European descent. However, only 2-4 percent of individuals are truly Sd(a-) and may produce anti-Sda.
BACKGROUND: Traumatic brain injury (TBI) constitutes a global epidemic. Overall outcome is poor, with mortality ranging from 10 to 70% and significant long-term morbidity. Several experimental reports have claimed effect on traumatic edema, but no clinical trials have shown effect on edema or outcome. Antisecretory factor, an endogenous protein, is commercially available as Salovum®, which is clas
Purpose: To describe the rationale and design of the VOYAGER (NCT05476926) study, which aims to investigate the safety and effectiveness of faricimab and the Port Delivery System with ranibizumab (PDS) for neovascular age-related macular degeneration (nAMD) or diabetic macular edema (DME) in clinical practice. VOYAGER also aims to understand drivers of clinical practice treatment outcomes by gaini
