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The development of multigene classifiers for cancer prognosis, treatment prediction, molecular subtypes or clinicopathological groups has been a cornerstone in transcriptomic analyses of human malignancies for nearly two decades. However, many reported classifiers are critically limited by different preprocessing needs like normalization and data centering. In response, a new breed of classifiers,
Background: Direct oral anticoagulants (DOACs) reduce the rate of thromboembolism in patients with atrial fibrillation but the benefits and risks in survivors of intracerebral haemorrhage are uncertain. We aimed to determine whether DOACs reduce the risk of ischaemic stroke without substantially increasing the risk of recurrent intracerebral haemorrhage. Methods: PRESTIGE-AF is a multicentre, open
Purpose: To present the outcomes of a randomised clinical trial for the treatment of progressive keratoconus using different kinds of riboflavin and the addition of sterile water in thin corneae. Methods: A randomised study using epithelium-off corneal cross-linking (CXL) with continuous UVA irradiance 9 mW/cm2 for 10 min (total fluence 5.4 J/cm2) and two kinds of riboflavin solutions: (i) isoosmo
Background: Proton beam therapy (PBT) offers dosimetric advantages in pediatric radiotherapy by reducing radiation exposure to healthy tissues. However, broad implementation raises important ethical, logistical, and equity considerations, especially in settings with limited access to advanced technologies. Procedure: This position paper by the Paediatric Radiation Oncology Society (PROS) reviews t
In political debates, ‘children’ and notions of ‘the best interest of the child’ are used to dramatize and limit societal negotiations of sexuality and sexualities (Pellegrini, 2009). At the same time, “There has been a tendency amongst those who research marginalized youth to view social groups or identities as fixed units of analysis” (Loutzenheiser, 2007). With my presentation, I will engage no
Detta är en kvalitativ intervjustudie med grund i fenomenologi och queerteori där sex sångpedagoger har intervjuats om deras individuella sångundervisning med transpersoner. Studien undersöker pedagogernas erfarenheter av och kunskaper om att undervisa transpersoner i sång, hur de resonerar kring könsnormer inom sång samt hur de beskriver dialogen med sina elever om röst, sång och identitet. ResulThis is a qualitative interview study based on phenomenology and queer theory where six voice teachers were interviewed about their one-on-one singing lessons with trans individuals. The study researches the teachers’ experience with and knowledge about teaching singing to trans people, how they reflect on gender norms related to singing as well as how they describe the dialogue with their student
Observations of young stellar objects (YSOs) in centimeter bands can probe the continuum emission from growing dust grains, ionized winds, and magnetospheric activity that are intimately connected to the evolution of protoplanetary disks and the formation of planets. We carried out sensitive continuum observations toward the Ophiuchus A star-forming region, using the Karl G. Jansky Very Large Arra
The special interest group on sensitive skin of the International Forum for the Study of Itch previously defined sensitive skin as a syndrome defined by the occurrence of unpleasant sensations (stinging, burning, pain, pruritus and tingling sensations) in response to stimuli that normally should not provoke such sensations. This additional paper focuses on the pathophysiology and the management of
In England saltmarshes account for less than 0.5% of the land area; however they have a very high biodiversity value and provide significant economic and social services. Climate change, continuous coastal urbanisation and port development are serious concerns for coastal protection planners, city councils and state government agencies interested in balancing the social, economic and environmental
Mitigation of greenhouse gas (GHG) emissions is essential for us humans to curb climate change. Around a fifth of the anthropogenic GHG emissions stem from the construction sector. Much come from energy used for space and water heating within buildings, but an increasing proportion comes from the manufacturing of the building materials and is virtually embodied within buildings. This is called Emb
TECK (thymus-expressed chemokine), a recently described CC chemokine expressed in thymus and small intestine, was found to mediate chemotaxis of human G protein-coupled receptor GPR-9-6/L1.2 transfectants. This activity was blocked by anti-GPR-9-6 monoclonal antibody (mAb) 3C3. GPR-9-6 is expressed on a subset of memory alpha4beta7(high) intestinal trafficking CD4 and CD8 lymphocytes. In addition,
This study with the Civil Aircraft for Regular Investigation of the Atmosphere Based on an Instrument Container (CARIBIC) platform investigates the aerosol elemental concentrations at 9-11 km altitude in the northern hemisphere. Measurements from 31 intercontinental flights over a 2-year period between Germany and Sri Lanka/Maldives in the Indian Ocean are presented. Aerosol samples were collected
On the basis of existing detailed kinetic schemes a general and consistent mechanism of the oxidation of hydrocarbons and the formation of higher hydrocarbons was compiled for computational studies covering the characteristic properties of a wide range of combustion processes. Computed ignition delay times of hydrocarbon -oxygen mixtures (CH4-, C2H6-, C3H8-, n-C4H10-, CH4 + C2H6-, C2H4, C3H6-O-2)
hEP4-R (human prostaglandin E2 receptor, subtype EP4) is a Gs-linked heterotrimeric GPCR (G-protein-coupled receptor). It undergoes agonist-induced desensitization and internalization that depend on the presence of its C-terminal domain. Desensitization and internalization of GPCRs are often linked to agonist-induced b-arrestin complex formation, which is stabilized by phosphorylation. Subsequentl
Germline mutations in BRCA1 and BRCA2 confer high risks of breast and ovarian cancer, but the average magnitude of these risks is uncertain and may depend on the context. Estimates based on multiple-case families may be enriched for mutations of higher risk and/or other familial risk factors, whereas risk estimates from studies based on cases unselected for family history have been imprecise. We p
