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A brief, 3 min period of global forebrain ischemia in the rat, induced by bilateral common carotid occlusion combined with hypotension, confers resistance to hippocampal pyramidal neurons against a subsequent 10 min ischemia, which is normally lethal to these cells. The molecular mechanisms underlying this ischemic preconditioning, or tolerance, are poorly understood. The tumor suppressor p53 is a
The changes in extracellular Ca2+ (Cae) and K+ (Ke) activities were studied in the rat brain during insulin-induced hypoglycemia. At about the time of onset of isoelectric EEG in severe insulin-induced hypoglycemia (300-g male Wistar rats under 70% N2O anaesthesia), there was an increase in Ke which, at ∼13 mM, was associated with a fall in Cae. Ke peaked at 48 ± 12 mM, and Cae at 0.18 ± 0.28 mM.
Next generation targeted sequencing of HLA-DRB1, -DRB3, -DRB4 and -DRB5 (abbreviated as DRB345) provides high resolution of functional variant positions to investigate their associations with type 1 diabetes risk and with autoantibodies against insulin (IAA), GAD65 (GADA), IA-2 (IA-2A) or ZnT8 (ZnT8A). To overcome exceptional DR sequence complexity due to high polymorphisms and extended linkage-di
It has been proposed that the EU Ecodesign Directive can promote resource efficiency through relevant ecodesign requirements. This paper examines the potential for rare earth element (REE) resource efficiency improvements in the event the current regulation for electric motors under the Ecodesign Directive is to be extended to comprise REE-based permanent magnet motors. The research is based on li
Background. Flattening filter-free (FFF) beams are an emerging technology that has not yet been widely implemented as standard practice in radiotherapy centers. To facilitate the clinical implementation of FFF, we attempted to elucidate the difference in plan quality and treatment delivery time compared to flattening filter beams (i.e. standard, STD) for several patient groups. We hypothesize that
Background Female sex is known to have increased perioperative mortality in cardiac surgery. Studies reporting effects of sex on outcome following surgical repair for acute Type A aortic dissection (ATAAD) have been limited by small cohorts of heterogeneous patient populations and have shown diverging results. This study aimed to compare perioperative characteristics, operative management, and pos
Purpose: In the last decade, the research community has focused on defining reliable biomarkers for the early detection of Alzheimer’s disease (AD) pathology. In 2017, the Geneva AD Biomarker Roadmap Initiative adapted a framework for the systematic validation of oncological biomarkers to cerebrospinal fluid (CSF) AD biomarkers—encompassing the 42 amino-acid isoform of amyloid-β (Aβ42), phosphoryl
A search for pair production of scalar leptoquarks, each decaying into either an electron or a muon and a top quark, is presented. This is the first leptoquark search using ATLAS data to investigate top-philic cross-generational couplings that could provide explanations for recently observed anomalies in B meson decays. This analysis targets high leptoquark masses which cause the decay products of
The results of a search for direct pair production of top squarks and for dark matter in events with two opposite-charge leptons (electrons or muons), jets and missing transverse momentum are reported, using 139 fb−1 of integrated luminosity from proton-proton collisions at s = 13 TeV, collected by the ATLAS detector at the Large Hadron Collider during Run 2 (2015–2018). This search considers the
Background: Parents of children with complex right ventricular outflow tract (RVOT) anomalies are con-fronted with their child’s need for heart surgery early in life and repeated reoperations later on. Preoperative assessment needs to be performed whenever an indication for reoperation is suspected. The aim was to illuminate the experiences of parents of children diagnosed with RVOT anomalies, in
In political debates, ‘children’ and notions of ‘the best interest of the child’ are used to dramatize and limit societal negotiations of sexuality and sexualities (Pellegrini, 2009). At the same time, “There has been a tendency amongst those who research marginalized youth to view social groups or identities as fixed units of analysis” (Loutzenheiser, 2007). With my presentation, I will engage no
Major crises create quite visible and serious problems for firms and regions. However there is a more or less continuous process of structural change going on, not least due to a globalizing economy. This less often highlighted process poses a number of challenges to regions and local communities. When firms or whole industries are heavily hit by change, windows of opportunity open up. In this pap
A search for the direct production of charginos and neutralinos in final states with three leptons and missing transverse momentum is presented. The analysis is based on 20.3 fb(-1) of root s = 8TeV proton-proton collision data delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with the Standard Model expectations and limits are set in R-parity
The results of a search for charged Higgs bosons decaying to a T lepton and a neutrino. H-+/- -> T-+/-nu, are presented. The analysis is based on 19.5 fb(-1) of proton-proton collision data at root s = 8 TeV collected by the ATLAS experiment at the Large Hadron Collider. Charged Higgs bosons are searched for in events consistent with top-quark pair production or in associated production with a top
This dissertation is set in the context of the modern space age, which is characterised by an overall increase in space activities on a global scale and a relative increase in private and commercial space activities. Space has become a business case.This study analyses the principle of international responsibility for activities in outer space as mainly codified in Article VI of the Outer Space Tr
A generic search for resonances is performed with events containing a Z boson with transverse momentum greater than 100 GeV, decaying into e + e − or μ + μ −. The analysed data collected with the ATLAS detector in proton-proton collisions at a centre-of-mass energy of 13 TeV at the Large Hadron Collider correspond to an integrated luminosity of 139 fb −1. Two invariant mass distributions are exa
Searches for the exclusive decays of Higgs and Z bosons into a vector quarkonium state and a photon are performed in the μ+μ-γ final state with a proton–proton collision data sample corresponding to an integrated luminosity of 139 fb - 1 collected at s=13 TeV with the ATLAS detector at the CERN Large Hadron Collider. The observed data are compatible with the expected backgrounds. The 95% confidenc
