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A short period of sublethal preconditioning ischemia (3 min) followed by two days of reperfusion provides almost complete protection against ischemic cell death induced by a second (9 min) lethal ischemic episode. Here, we have investigated the extracellular signal-regulated protein kinase kinase and extracellular signal-regulated protein kinase, two kinases known to activate gene transcription an
A brief, 3 min period of global forebrain ischemia in the rat, induced by bilateral common carotid occlusion combined with hypotension, confers resistance to hippocampal pyramidal neurons against a subsequent 10 min ischemia, which is normally lethal to these cells. The molecular mechanisms underlying this ischemic preconditioning, or tolerance, are poorly understood. The tumor suppressor p53 is a
The changes in extracellular Ca2+ (Cae) and K+ (Ke) activities were studied in the rat brain during insulin-induced hypoglycemia. At about the time of onset of isoelectric EEG in severe insulin-induced hypoglycemia (300-g male Wistar rats under 70% N2O anaesthesia), there was an increase in Ke which, at ∼13 mM, was associated with a fall in Cae. Ke peaked at 48 ± 12 mM, and Cae at 0.18 ± 0.28 mM.
Next generation targeted sequencing of HLA-DRB1, -DRB3, -DRB4 and -DRB5 (abbreviated as DRB345) provides high resolution of functional variant positions to investigate their associations with type 1 diabetes risk and with autoantibodies against insulin (IAA), GAD65 (GADA), IA-2 (IA-2A) or ZnT8 (ZnT8A). To overcome exceptional DR sequence complexity due to high polymorphisms and extended linkage-di
I uppsatsen undersöks i vilken mån som personal inom hälso- och sjukvården kan omfattas av rättsskyddet i 17 kap. 1 §§ BrB. Lagbestämmelserna anger rekvisiten för våld och hot mot tjänsteman och innebär ett utökat rättsskydd för den som uppfyller definitionen av tjänstemannabegreppet. Uppsatsen kommer därför att utreda omfattningen av rättskyddet samt vilka kriterier som ska uppfyllas för att tjän
I vår studie har vi kommit fram till att det inte finns någon entydigt och klart svar på våra frågeställningar. Vårt exempelföretag Previa visar och mäter att kundens investering ger effekt genom ett unikt kommunikationsverktyg som heter Hälsoeffekten. Verktyget fungerar så att företagets alla siffror förs in i ett system som ger en överblick av företaget. Previa kan sällan garantera att den önska
Denna uppsats syftar till att undersöka hur EU-rätten har påverkat svenska arbetstagarorganisationers möjligheter att använda sig utav stridsåtgärder och vilka effekter denna påverkan kan ha på den svenska arbetsmarknadsmodellen. För det första måste det sägas att EU-domstolens genom Laval och Viking har gjort det svårare för arbetstagarorganisationer att vidta stridsåtgärder då domstolen ansett aThis thesis has the aim of investigating how EU-law has affected the legal position regarding Swedish trade union’s possibilities of undertaking industrial actions. It also aims at determining whether the influence of EU-law on the right to undertake industrial actions has had any effects on the Swedish model. According to CJEU’s judgements in Laval and Viking it must be said that the possibilit
This paper uses an explorative case study approach to study the potential of export-led growth in the Ethiopian economy by focusing on the agribusiness sector of the economy. The paper draws on a GVC framework to analyse Ethiopian agribusiness exports and the use of the preferential trade agreement, Everything but Arms, as a potential enabler for further export growth. The aim of the paper is to s
Upphovsrätten utmanas ständigt av nya teknologiska fenomen. På senare tid har den tekniska utvecklingen möjliggjort att alster som tidigare var beroende av mänskligt skapande kan åstadkommas genom mer eller mindre automatiserade processer. I denna kategori finner vi kamerafällor som förenklat kan beskrivas som kameror som antingen ställs in för att ta fotografier konstant eller vid ett visst tidsiCopyright law is constantly challenged by new technological phenomena. Recently, new technology has enabled the making of creations through more or less autonomous processes. Some of these creations were previously dependent on human creativity for its existence. Situated in this category are camera traps. Camera traps can somewhat simplified be explained as cameras that are either set to take pic
This study aims to analyze the effects of competition on quality, efficiency, produced volume and gaming the system of specialized health care in Sweden, after implementation of the Freedom of Choice Act (LOV, Lagen om Vårdval). This is done by using data for specialized ophthalmology, which is a patient-elective diagnostic category. The motive behind the law, which established free entry for priv
Fiducial cross-sections for [Formula: see text] production with one or two additional b-jets are reported, using an integrated luminosity of 20.3 fb[Formula: see text] of proton-proton collisions at a centre-of-mass energy of 8 TeV at the Large Hadron Collider, collected with the ATLAS detector. The cross-section times branching ratio for [Formula: see text] events with at least one additional b-j
Results are presented of a search for particles decaying into final states with significant missing transverse momentum and exactly two identical flavour leptons (e, mu) of opposite charge in root s = 7 TeV collisions at the Large Hadron Collider. This channel is particularly sensitive to supersymmetric particle cascade decays producing flavour correlated lepton pairs. Flavour uncorrelated backgro
Life on Earth was sharply disrupted 66 Ma ago as an asteroid hit the sea-floor in what is today Yucatan Peninsula, Mexico. Approximately 600 km(3) of sedimentary rock were vapourized, ejected into the atmosphere and subsequently deposited globally as an ejecta apron and fallout layer. Proximal ejecta deposits occur in Belize and southern Mexico where the so called Albion island spheroid bed is sup
Abstract In childhood atopic dermatitis (AD) is the most frequent inflammatory condition. Validated eczema questionnaires have been available for schoolchildren only, but the incidence of atopic dermatitis is highest during infancy. Evidence is needed on the further development of asthma, and rhinitis in these infants with AD and on remission of AD in children. We aimed to validate a parental ques
The modern medical treatment of HIV with antiretroviral therapy (ART) has drastically reduced the morbidity and mortality in patients infected with this virus. ART has also been shown to reduce the transmission risk from individual patients as well as the spread of the infection at the population level. This position statement from the Public Health Agency of Sweden and the Swedish Reference Group
A search for a new resonance decaying to a W or Z boson and a Higgs boson in the [Formula: see text] final states is performed using 20.3 fb[Formula: see text] of pp collision data recorded at [Formula: see text] 8 TeV with the ATLAS detector at the Large Hadron Collider. The search is conducted by examining the WH / ZH invariant mass distribution for a localized excess. No significant deviation f
A search has been performed for the experimental signature of an isolated photon with high transverse momentum, at least one jet identified as originating from a bottom quark, and high missing transverse momentum. Such a final state may originate from supersymmetric models with gauge-mediated supersymmetry breaking in events in which one of a pair of higgsino-like neutralinos decays into a photon
Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb[Formula: see text] of [Formula: see text] TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with [Formula: see text] GeV and no leptons. Nine signal regions are considered with increasing mi
