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Objective: To assess the proportion of participants reconsidering their willingness to undergo surgery after 3 and 12 months. Secondary aims were to analyze and compare the characteristics of individuals willing and unwilling to undergo joint surgery for osteoarthritis (OA) before a first-line intervention, and to study the association between pain intensity, walking difficulties, self-efficacy, a
The present investigation emphases on rotation effects on internal cooling of gas turbine blades both numerically and experimentally. The primary motivation behind this work is to investigate the possibility of heat transfer enhancement by dean vortices generated by Coriolis force and U-bend with developing turbulent in the view point of the field synergy principle and secondary flow intensity ana
Background: Research has indicated that interactive, computerized case simulations using immersive virtual reality (VR) technology may be beneficial in the augmentation of conventional methods of assessment and treatment in forensic psychiatry, primarily through providing an engaging and safe environment in which the user can practice and learn skills and behaviors. However, there does not appear
Recent outlooks suggest a long-term relevance of internal combustion engines for both power generation and transportation. Nonetheless, stringent pollutant reduction requirements combined with new CO2 mandates draws a challenging scenario, requiring intensive research and development activities to develop and optimize combustion modes to fulfill these requirements. Among the recent advancements, t
Doxorubicin (DOX) is a cornerstone drug in the treatment of osteosarcoma. However, achieving sufficient concentration in the tumor tissue after systemic administration with few side effects has been a challenge. Even with the most advanced nanotechnology approaches, less than 5% of the total administered drug gets delivered to the target site. Alternatives to increase the local concentration of DO
Background In cohorts with voluntary participation, participants may not be representative of the underlying population, leading to distorted estimates. If the relevant sources of selective participation are observed, it is however possible to restore the representativeness by reweighting the sample to resemble the target population. So far, few studies in epidemiology have applied reweighting bas
PURPOSE: We performed an exploratory analysis of prostate cancer-related pain and fatigue on health-related quality of life in patients with metastatic castration-sensitive prostate cancer receiving apalutamide (240 mg/day) or placebo, with continuous androgen deprivation therapy (ADT), in the phase 3, randomized, double-blind, placebo controlled TITAN trial (NCT02489318). MATERIALS AND METHODS: P
Introduction This study aims to clarify the role(s) of endogenous sex hormones to influence health outcomes in men, specifically to define the associations of plasma testosterone with incidence of cardiovascular events, cancer, dementia and mortality risk, and to identify factors predicting testosterone concentrations. Data will be accrued from at least three Australian, two European and four Nort
INTRODUCTION: Diabetes mellitus (DM) and colorectal cancer (CRC) share some risk factors, including lifestyle and metabolic disturbances. We aimed to provide in-depth information on the association of CRC risk, especially early-onset CRC, with DM, family history of CRC, and age at DM diagnosis. METHODS: A nationwide cohort study was conducted using Swedish family cancer data sets, inpatient, and o
We investigated type 2 diabetes (T2D) genetic susceptibility via multi-ancestry meta-analysis of 228,499 cases and 1,178,783 controls in the Million Veteran Program (MVP), DIAMANTE, Biobank Japan and other studies. We report 568 associations, including 286 autosomal, 7 X-chromosomal and 25 identified in ancestry-specific analyses that were previously unreported. Transcriptome-wide association anal
Long term multiple systemic antibiotics form the cornerstone in the treatment of bone and joint tuberculosis, often combined with local surgical eradication. Implanted carriers for local drug delivery have recently been introduced to overcome some of the limitations associated with conventional treatment strategies. In this study, we used a calcium sulphate hemihydrate (CSH)/nanohydroxyapatite (nH
OBJECTIVE: Pulse pressure (PP) is a risk marker for cardiovascular disease (CVD) in individuals 50 years and older. Inflammation is suggested to influence atherosclerosis, but could also increase PP. We aimed to examine the combined effects of PP and the inflammatory marker sialic acid, and their independent roles on CVD risk. METHODS: From a population-based study in Sweden between 1962 and 196
OBJECTIVES: /st> To investigate the association between meniscal pathology and incident or enlarging bone marrow lesions (BML) in knee osteoarthritis. METHODS: /st> The authors studied subjects from the Multicenter Osteoarthritis Study aged 50-79 years either with knee osteoarthritis or at high risk of the disease. Baseline and 30-months magnetic resonance images of knees (n=1344) were scored for
The aim of this thesis was to study nurse assistants’ experience of palliative care and to investigate how an intervention with a focus on a palliative care approach in residential care facilities influenced the nurse assistants and their work situation. The thesis is based on two qualitative and two quantitative studies, focusing on nurse assistants working at residential care facilities for olde
Studiens syfte är att få fram hur FN ser på sexuella övergrepp som utförs av deras egen personal. Jag har utfört en diskursanalys utifrån frågeställningarna om det pågår ett förebyggande arbete inom FN för att stoppa sexuella övergrepp och hur FN talar om övergreppen och förövarna. Teorin jag använder mig av är R. W. Connells teori om maskulinitet som utgår från tre relationstyper och fyra maskuli
Denna uppsats argumenterar för behovet av mer forskning, förståelse och medvetenhet kring destruktiva konsekvenser av ledarskap. Företag drabbas i dag av nedskärningar, stora förändringar och hög grad av arbetsbelastning. Dessa faktorer skapar tillsammans en grogrund för mellanmänskliga konflikter inom företagen, varför ledarskap får sig en allt större och mer betydelsefull roll. Genom att utforsk
Representationskompetensen hos den verkställande direktören i svenska aktiebolag regleras genom 8 kap. 36 § ABL och därigenom rekvisitet ”löpande förvaltning” i 8 kap. 29 § ABL. Vad denna löpande förvaltning omfattar är dock inte helt tydligt och kan variera kraftigt mellan olika typer av bolag och situationer. Detta kan skapa såväl praktiska som juridiska problem för både bolag och den verkställaThe legal capacity for Chief Executive Officers (CEO) in Swedish corporations is regulated through the legal condition “everyday operations” in Chapter 8, 36 § of the Swedish Companies Act of 2005. What is meant with “everyday operations” is not completely clear and can vary massively between different kinds of companies and situations. This may cause problems from both a practical and a jurisdict
