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There is considerable enthusiasm for the prospect of using common polymorphisms (primarily single nucleotide polymorphisms; SNPs) in candidate genes to unravel the genetics of complex disease. This approach has generated a number of findings of loci which are significantly associated with sporadic Alzheimer's disease (AD). In the present study, a total of 15 genes of interest were chosen from amon
Toxoplasma gondii infection can lead to life-threatening systemic disease in the immunocompromised individual and in the developing fetus. Despite intensive investigation in animal models of toxoplasmosis, the processes leading to systemic dissemination remain poorly characterized. In the present study, in vivo bioluminescence imaging (BLI) was applied to the Toxoplasma mouse model to study the dy
Background and purpose Tibial osteotomy by the hemicallotasis technique (HCO) requires strong pin fixation. We compared pin fixation in HCO using a new self-drilling XCaliber pin (Orthofix) with optimized thread and tip design, with the commonly used standard pin (Orthofix). Patients and methods 50 patients, mean age 51 (35-66) years, to be treated by HCO were randomized to standard pins or XCalib
The possible contribution of HLA-DRB3, -DRB4 and -DRB5 alleles to type 1 diabetes risk and to autoantibodies against insulin (IAA), GAD65 (GADA), IA-2 (IA-2A) or ZnT8 against either of the three amino acid variants, R, W or Q at position 325 (ZnT8RA, ZnT8WA, and ZnT8QA, respectively) at clinical diagnosis is unclear. Next generation sequencing (NGS) was therefore used to determine all DRB alleles
Scand J Caring Sci; 2011 Individual placement and support - a model to get employed for people with mental illness - the first Swedish report of outcomes Lack of participation in the open labour market is highly prevalent for people with a mental illness across countries, and the proportion of people who get some kind of sickness benefit because of mental illness is steadily growing in Europe. Voc
We propose a method for dividing large regions into biogeographical sub-regions based mainly on natural disturbance regime, forest history and potential tree species distribution. This subdivision could be used as a guide when designing conservational strategies and management plans for landscapes and protected areas. At present, conservational strategies and management of valuable areas on the on
This paper examines the assumption that the volume of domestic patenting in Vietnam is too low and needs to be expanded. The structure and state of development of the Vietnamese economy and a set of relevant systems - including the Science and Technology (S&T) System, the Intellectual Property System, the National Innovation System (NIS), and the Science, Technology and Innovation (STI) Policy
In the present investigation, we sought to refine the classification of urothelial carcinoma by combining information on gene expression, genomic, and gene mutation levels. For these purposes, we performed gene expression analysis of 144 carcinomas, and whole genome array-CGH analysis and mutation analyses of FGFR3, PIK3CA, KRAS, HRAS, NRAS, TP53, CDKN2A, and TSC1 in 103 of these cases. Hierarchic
Human embryonic stem cells (hESCs) are a potential source of dopaminergic neurons for treatment of patients with Parkinson's disease (PD). Dopaminergic neurons can be derived from hESCs and display a characteristic midbrain phenotype. Once transplanted, they can induce partial behavioral recovery in animal models of PD. However, the potential research field faces several challenges that need to be
To study cell-free fetal hemoglobin (HbF) and the heme-scavenger α1- microglobulin (A1M) in patients with manifest preeclampsia (PE) and how these proteins performed as possible biomarkers of PE and adverse maternal and fetal outcomes.
There is a serious need in the automotive industry to predict surface defects in outer panels. Measures to prevent these defects can not be taken until a test part has been manufactured. This costs a lot in time and money. Within the present project stamping tools for a model part resembling the area around the fuel filler lid was developed. This is an area of the outer surface of a car, which is
For Rb 87 the level crossing method was applied to the first four levels ( n = 5, 6, 7, and 8) of the np 2 P 3/2 series in the Rb I spectrum. By using magnetic dipole interaction constants from corresponding zero field optical double resonance experiments, the electronic g J factors of 5, 6, and 7 p 2 P 3/2 were calculated from the level crossing data. For these levels the natural radiative lifeti
Background Laser capture microdissection (LCM) can be applied to tissues where cells of interest are distinguishable from surrounding cell populations. Here, we have optimized LCM for fresh frozen normal breast tissue where large amounts of fat can cause problems during microdissection. Since the amount of DNA needed for genome wide analyses, such as single nucleotide polymorphism (SNP) arrays, is
This thesis includes four appended papers. The thesis describes the challenges and advantages of the use of FE-analysis in the design of a component forming process in the automotive industry. Today, shortened lead-times in the automotive industry have dramatically increased the need for more efficient development methods in each stage of the process development chain. In order to decrease the lon
The presentation will describe the results of a randomized controlled trial of cognitive therapy for childhood GAD, including analyses of mediation of outcome by changes in intolerance of uncertainty.
A sound pedagogical framework must be explored and identified to implement opportunities for collaborative learning through international exchange. This paper identifies the framework used by two universities, in Sweden and the United States. Virtual learning environments and meaningful learning activities can be constructed using web-based learning platforms. The goal for this initiative was 'int
