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We sought to assess the impact of amino-acid (18)F-fluoro-ethyl-tyrosine (FET) positron emission tomography (PET) on the volumetric target definition for radiation therapy of high-grade glioma versus the current standard using MRI alone. Specifically, we investigated the influence of tumor grade, MR-defined tumor volume, and the extent of surgical resection on PET positivity.
Aromatic side chains are prevalent in protein binding sites, perform functional roles in enzymatic catalysis, and form an integral part of the hydrophobic core of proteins. Thus, it is of great interest to probe the conformational dynamics of aromatic side chains and its response to biologically relevant events. Indeed, measurements of (13)C relaxation rates in aromatic moieties have a long histor
A thermoelastic–plastic body consisting of two phases, a solid and a fluid, each comprising two constituents is considered where one constituent in one phase is allowed to exchange mass with another constituent (of the same substance) in the other phase. A large strain setting is adopted and the formulation applies to general anisotropy and the existence of residual stresses. Generalized forms of
Existing methods of primary stroke prevention are not sufficiently effective. Based on the recently developed Stroke Riskometer app, a new mass-elevated risk stroke/cardiovascular disease prevention' approach as an addition to the currently adopted absolute risk stroke/cardiovascular disease prevention approach is being advocated. We believe this approach is far more appealing to the individuals c
In many countries, practice-oriented programs have been recast as university programs, fueling debate on the purpose of higher education. We highlight two ways of talking about the challenges for higher education we think are already familiar to readers. We label them ‘political-worry discourse’ and ‘academic-worry discourse’. We argue for a third position that gives due recognition to the turn in
As a scientific field of study, neuroepidemiology encompasses more than just the descriptive study of the frequency, distribution, determinants and outcomes of neurologic diseases in populations. It also includes experimental aspects that span the full spectrum of clinical and population science research. As such, neuroepidemiology has a strong potential to inform implementation research for globa
Background and Aims A shift from outcrossing to selfing is thought to reduce the long-term survival of populations by decreasing the genetic variation necessary for adaptation to novel ecological conditions. However, theory also predicts an increase in adaptive potential as more of the existing variation becomes expressed as homozygous genotypes. So far, relatively few studies have examined how a
Several treatment alternatives for food waste can result in both energy and nutrient recovery, and thereby potential environmental benefits. However, according to the European Union waste management hierarchy, waste prevention should be the prioritized strategy to decrease the environmental burdens from all solid waste management. The aim of the present study was therefore to investigate the poten
As a lecturer in mathematics for first-year university students one faces several challenging problems; big classes, low motivation and a high level of abstraction. Based on interviews with several experienced university lecturers in mathematics, we present a toolbox of tips and tricks intended to be used when reflecting over one's own teaching in order to improve it.
The harmful effects of cyanotoxins in surface waters have led to increasing demands for accurate early warning methods. This study proposes a capacitive immunosensor for broad-spectrum detection of the group of toxic cyclic peptides called microcystins (∼80 congeners) at very low concentration levels. The novel analytical platform offers significant advances compared to the existing methods. Monoc
Renewable energy systems are likely to become wide spread in the future due to environmental demands. As a consequence of the dispersed nature of renewable energy systems, this implies that there will be a distributed generation of electric power. Since most of the distributed electrical energy sources do not provide their electric power at line frequency and voltage, a DC bus is a useful common c
The paper is in part an evaluation of using virtual focus groups in existing commercial platforms as a research method, in part a pilot study on motives and perceptions of Facebook users concerning political participation in social media. Two focus groups were set up in the commercial social network Facebook, consisting each of six participants, all of them residing in Sweden. One of the groups co
The use of a hydrogen-sensitive palladium-metal oxide semiconductor (Pd-MOS) sensor in combination with a membrane for liquid-to-gas transfer for the detection of dissolved hydrogen was investigated. The system was evaluated with known concentrations of dissolved hydrogen in water. The lowest concentration detected with this set-up was 160 nM. The method was applied to monitoring of a laboratory-s
The TRIPS Agreement allows WTO Members to enact and apply appropriate domestic competition law to address IPR-related anti-competitive practices. However, these flexibilities in the TRIPS Agreement do not provide any specific guidance for WTO Members. The application of domestic competition law to IPR abuses in technology transfer varies a great deal between developed and developing countries, and
This paper describes the design, simulation and measurement of a GaN power amplifier suitable for envelope and phase signal combination. The low-frequency envelope signal is used to vary the gate (bias) voltage of the device, resulting in a pulse width modulated drain voltage, while modulation of supply voltage or current is avoided. The test circuit is implemented using a discrete GaN HEMT power
Two alternative Human-Machine-Interface solutions for in-vehicle speed support were evaluated in field trials in Hungary and Spain. Twenty vehicles on both test sites were equipped with two kinds of systems: 1) support via an Active Accelerator Pedal and 2) warning via beep signals and flashing red light when exceeding the speed limit. The test drivers drove one month with each system. Both system
