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Introduction: Opinions differ on what drugs have both a rationale and a development potential for the treatment of bladder storage dysfunction. Areas covered: In the present review, the focus is given to small molecule blockers of TRP channels (TRPV1, TRPV4, TRPA1, and TRPM8), P2 × 3receptor antagonists, drugs against oxidative stress, antifibrosis agents, cyclic nucleotide–dependent pathways, and
PURPOSE: To follow the clinical outcome after surgery for cervical radiculopathy caused by degenerative cervical disc disease and to compare it with the outcome after conservative treatment.METHOD: Forty-three patients all awaiting surgery were studied prospectively. A control group of 39 conservatively treated patients were chosen, matched for gender and age. All patients rated their Sickness Imp
The nature of work has already, for some time, been undergoing major changes as a result of technological progress. Mobile, virtual and cloud technologies, and the infrastructures that support them, are increasingly enabling work to be done from anywhere and at any time. The COVID-19 pandemic has further accelerated this process, driving a large share of white-collar knowledge work to remote and h
AIM: To compare two identification methods for risky drinking in primary health care centres (PHCs).METHODS: Sixteen PHCs from three Swedish counties were randomized into strands: consultation-based early identification (CEI) or systematic screening early identification (SS). Measurements took place at baseline and during two intervention periods. Patients filled in questionnaires including gender
Objective: This study aimed to report the initial experience with a novel bidirectional double cuff inner branch design for incorporation of renal and mesenteric arteries in patients undergoing fenestrated and branched endovascular aortic repair (F/BEVAR). Methods: A retrospective review was undertaken of the experience of F/BEVAR with grafts integrating at least one bidirectional double cuffed in
Evacuation models commonly employ pseudorandom sampling from distributions to represent the variability of human behaviour in the evacuation process, otherwise referred to as ‘behavioural uncertainty’. This paper presents a method based on functional analysis and inferential statistics to study the convergence of probabilistic evacuation model results to inform deciding how many repeat simulation
The trigeminal system is key to the pathophysiology of migraine and cluster headache, two primary headache disorders that share many features. Recently, MER proto-oncogene tyrosine kinase (MERTK), a cell surface receptor, was strongly associated with cluster headache through genetic studies. Further, the MERTK ligand galectin-3 has been found to be elevated in serum of migraine patients. In this s
EXECUTIVE SUMMARY: Microbes are all pervasive in their distribution and influence on the functioning and well-being of humans, life in general and the planet. Microbially-based technologies contribute hugely to the supply of important goods and services we depend upon, such as the provision of food, medicines and clean water. They also offer mechanisms and strategies to mitigate and solve a wide r
Liskov, Rivest and Wagner laid the theoretical foundations for tweakable block ciphers (TBC). In a seminal paper, they proposed two (up to) birthday-bound secure design strategies — LRW1 and LRW2 — to convert any block cipher into a TBC. Several of the follow-up works consider cascading of LRW-type TBCs to construct beyond-the-birthday bound (BBB) secure TBCs. Landecker et al. demonstrated that j
Youth gun violence has surged in Sweden recently. Quantitative studies have described the prevalence and geographical locations of gun violence, but little research has examined how perpetrators and victims themselves experience and make sense of guns. This article draws on ethnographic interviews with young men who have firsthand experience of gun violence in a criminal context. Drawing on narrat
PurposeCare has been theorized as a relational practice, but the research has focused on providers rather than users. Older care users have been cast in a passive role, and their relational activities to help with the provision of their care or to support those who provide it are underexplored. The purpose of this study is to develop knowledge about home care use as a form of relational ‘work’.Met
The study provides a new assessment of the water balance components of the catchment (evapotranspiration, surface and lateral flow etc., and its spatial distribution and temporal variability) for the transboundary catchment of Western Dvina river within the poorly gaged Russian part of the catchment. The study focuses on modeling the inland flow generation processes using open source data and the
Gambling disorder can be treated with cognitive behavioral therapy (CBT), but treatment is under-dimensioned in many settings. For example, in Sweden, a setting with mixed responsibility for addiction treatment between health care and social services, treatment for gambling disorder has only recently been introduced in the responsibilities of public institutions. After the introduction of gambling
We present a unique comparative analysis, and evaluation of vision, radio, and audio based localization algorithms. We create the first baseline for the aforementioned sensors using the recently published Lund University Vision, Radio, and Audio (LuViRA) dataset, where all the sensors are synchronized and measured in the same environment. Some of the challenges of using each specific sensor for in
At COP27, Parties agreed to establish a fund for loss and damage. During the COP28 opening plenary, the Loss and Damage Fund was operationalised. Despite this progress, significant questions about access to funding remain unanswered. We engage with a key term in the decision texts–particularly vulnerable. How Parties frame and define the term ‘particularly vulnerable’ will influence funding alloca
Little is known about the aetiology of thymoma. This study aims to identify medical risk factors for thymoma as a systematic approach to new hypotheses on the aetiology of this disease. A European multi-centre case–control study was conducted from 1995 to 1997, including incident cases aged 35–69 years with thymoma. Altogether, we accepted 85 cases and 3350 controls, of which we interviewed 77 cas
