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Although biologics have revolutionized psoriasis treatment, they pose a significant burden on the healthcare budget. With the wide range of biologics available and the increasing number of biosimilars, insights into the real-world cost per responder (CPR) are required. Therefore, this study aims to evaluate the real-world CPR of adalimumab, ustekinumab, IL17-and IL23-inhibitors, incorporating both
Given many recent advanced embedding models, selecting pre-trained word representation (ie, word embedding) models best fit for a specific downstream NLP task is non-trivial. In this paper, we propose a systematic approach to extracting, evaluating, and visualizing multiple sets of pre-trained word embed-dings to determine which embeddings should be used in a downstream task. First, for extraction
In the current era, the meat supply chain plays a vital role in the food industry. The meat supply chain is experiencing significant challenges due to the increase in demand and Circular Economy (CE) challenges. In the meat supply chain, a huge waste is generated during the meat processing, and it is much needed to manage waste effectively, considering the large quantities of by-products, packagin
The establishment of innovation ecosystems has become an increasingly prevalent strategy for fostering territorial, economic and social development. However, the existing literature provides limited insights into the strategic conditions that enable the emergence of such ecosystems. This paper addresses this gap by identifying the critical elements and mechanisms underpinning their creation. Speci
What is the context?: Platelets contain three major types of granules (alpha granules, dense granules and lysosomal granules) that carry distinct cargo. Dense granules store small molecules such as calcium, serotonin and adenosine 5′-diphosphate (ADP) that are essential for platelet activation and aggregation. Impaired production or release of dense granules can affect blood clotting and cause inc
Universities offer a variety of services to students, staff, and affiliates, traditionally managed through physical campus cards. However, increasing mobility requirements and the need for secure, interoperable digital identity solutions call for a modernized approach to service access. This paper introduces eduTAP, an open-source concept and software framework that builds on top of digital wallet
Water structure is crucially important to protein function and catalysis and can be conserved throughout related proteins despite differences in sequence. The complex hydrogen-bonding networks formed by water molecules and protein residues have been studied extensively, and graph-theory-based methods have frequently been used to describe these networks. Although there exist a number of tools which
Large language models (LLMs) and their applications in low-resource languages (such as in Vietnamese) are limited due to lack of training data and benchmarking datasets. This paper introduces a practical real-world implementation of a question answering system for Vietnamese, called ViGPTQA, leveraging the power of LLM. Since there is no effective LLM in Vietnamese to date, we also propose, evalua
We present a novel deep neural network architecture for representing robot experiences in an episodic-like memory that facilitates encoding, recalling, and predicting action experiences. Our proposed unsupervised deep episodic memory model as follows: First, encodes observed actions in a latent vector space and, based on this latent encoding, second, infers most similar episodes previously experie
We describe an experimental setup for non-linear interaction and propagation of ultrashort and intense x-ray free-electron laser (XFEL) pulses in a dense gas. It allows one to provide high, but adjustable, target-gas pressures of up to 6 bar within a vacuum environment of 3∙10− 3 mbar or better. The setup enables investigation of intense x-ray propagation in an optically thick medium with minimal
Abstract – Introduction: Peripheral intravenous catheterization is commonly required in sick neonates but remains challenging due to small vessels, leading to multiple attempts and complications. This review evaluated the benefits and harms of device-assisted techniques versus standard technique. Methods: We searched MEDLINE, Embase, CENTRAL, Cochrane Reviews, WHO ICTRP, and ClinicalTrials.gov (Oc
We have generated two reporter plasmids that either monitor expression of human papillomavirus type 16 (HPV16) E2 mRNAs using splice site SA2709 or HPV16 E1C mRNAs utilizing splice site SA2582. In plasmid pE2sLuc, the entire E2 open reading frame was replaced by the secreted luciferase (sLuc) reporter gene and in the pE1nLuc plasmid the E1/E1C open reading frame was fused in frame with the nanoluc
Introduction: The first-line evidence-based treatment for chronic pain is multidisciplinary treatment involving pain-focused CBT. Studies have shown that changes in psychological flexibility (PF) during pain-focused CBT positively mediatesoutcomes, even when the treatment does not specifically target PF. While CBT and PF-based treatments for chronic pain yield small to moderate, but clinically mea
The transformation of CO2 and green hydrogen into methanol presents a sustainable route for chemical and fuel production. Conventional methanol synthesis catalysts, such as Cu/ZnO/Al2O3, employ Al2O3 as a structural promoter, while Ga2O3 has recently emerged as a promising alternative. This study compares Cu-based catalysts supported on Al2O3 (CA) and Ga2O3 (CG), prepared via coprecipitation of la
BackgroundChronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF) are characterized by persistent airway inflammation and airflow limitation. Measuring airway inflammation may be of value both in research and clinical practice. Calprotectin, a protein associated with neutrophil activation, serves as a potential biomarker for airway inflammation. This study evaluates the performance o
Inhalation administration of therapeutics is a crucial method for treatment of respiratory diseases, offering direct access to the target organ. However, the progression of candidate drugs is frequently impacted by clinical dose level limitations due to lung histopathological findings or functional effects identified in in vivo studies. Addressing these safety concerns is crucial in advancing comp
Studio recordings of music for English bass horn and string trio from the composers Louis Massonneau, Emma Jane Lloyd, and Ylva Lund Bergner, recorded at the St Cecilia's Hall in Edinburgh on 17 January 2026.
