Filetype
Large skeletal muscle injuries, such as a volumetric muscle loss (VML), often result in an incomplete regeneration due to the formation of a non-contractile fibrotic scar tissue. This is, in part, due to the outbreak of an inflammatory response, which is not resolved over time, meaning that type-1 macrophages (M1, pro-inflammatory) involved in the initial stages of the process are not replaced by
Ti-6Al-4V alloy obtained by powder metallurgy (PM) is a good candidate biomaterial in the manufacture of dental implants but its inherent porosity makes it have worse corrosion behavior than conventionally obtained alloys. In order to improve the corrosion and biological properties, surface modification technologies could be used. The plasma electrolytic oxidation (PEO) process is a novelty proces
A dislocation-based flow stress model is proposed to describe the behavior of Alloy 718 fabricated using laser-based and electron-beam powder bed fusion methods. This physics-based model is adaptive to microstructural variations including the size and volume fraction of γ″ precipitates, crystallographic texture, grain size and the density of immobile dislocations. Coupled with data from thermodyna
This invention is directed to a method for efficiently separating and purifying 13-dehydroxybaccatin III and 10-deacetylpaclitaxel with a high purity of 90% or higher purity, preferably 99.5% or higher purity, from taxane-containing materials such as Taxus species, and the thusly obtained highly pure 13-dehydroxybaccatin III and 10-deacetylpaclitaxel can be used as semi-synthetic precursors of pac
Electric scooters (e-scooters) have emerged as a fundamental component of urban micro-mobility, particularly in European cities during the Covid-19 pandemic. This study employs the Full Consistency Method (FUCOM) and Kendall rank correlation method to assess the preferences and priorities of university students in Catania, Italy, regarding e-scooter adoption. By analyzing influencing factors, this
Teams are dynamic systems that develop, adapt, and change as members interact and respond to their environments. Theory in organizational research emphasizes that team phenomena are multilevel, temporal, and often nonlinear. Yet, the statistical methods commonly used to study teams have lagged behind these theoretical advances, limiting empirical progress. This dissertation addresses this methodol
Despite several randomized controlled trials demonstrating the benefits of combination therapies for metastatic hormone-sensitive prostate cancer (mHSPC), a significant treatment gap persists. This initiative by the Prostate Cancer Foundation (PCF) convened stakeholders from academia, community practices, industry, and patient advocacy groups to address critical challenges in mHSPC care. Expert di
Information- and data literacy, the ability to critically examine and evaluate information and arguments in relation to empirical evidence, is increasingly crucial in a world overflowing with data and information from a multitude of sources. Information- and data literacy in younger students being understudied, we investigate these skills in Swedish 6th graders to learn more about the educational
Timber’s sustainability benefits make it an attractive construction material, but public concerns about fire safety remain a challenge. Many associate timber buildings with higher fire risks, particularly in taller structures, despite trusting regulations and professionals to ensure safety. This highlights a gap between public perception and technical knowledge. Designers have a professional respo
The rapid uptake of electric vehicles presents both opportunities and challenges for modern power systems. As charging demand increases, intelligent and data-driven approaches are essential to predict and manage future grid impacts. This paper presents a probabilistic and data-driven approach for generating realistic electric vehicle charging profiles, which can be integrated into probabilistic lo
The UK Hydrogen Strategy (August 2021) and subsequent Heat and Buildings Strategy (October 2021) affirm that a strategic decision is set to be taken by 2026 on the prospect of residential decarbonisation via ‘hydrogen homes’. As this decision date draws nearer, quantitative insights on consumer perceptions of hydrogen-fuelled heating and cooking appliances remain limited. The existing knowledge de
Forest loss, fragmentation, and transformation negatively impact forest biodiversity and ecosystem functionality worldwide. Improving landscape intactness and connectivity through restoration is critical. Determining where to restore remains, however, a challenge. As an approach for prioritizing restoration areas, we define connectivity forest (CFs) as forests outside recognized high conservation
The increasing use of digital tools in archaeology has vastly expanded our capacity to document and visualise the past, yet the reasoning that connects evidence to interpretation often remains implicit or undocumented. This paper addresses that gapby integrating Inference to the Best Explanation (IBE)—a philosophical model of hypothesis evaluation—into the Archaeological Interactive Report (AIR),
The Industrial Symbiosis Readiness Level Matrix (ISRLM) tool presented in this paper, was developed to address the challenges inherent in implementing and managing Industrial Symbiosis (IS) networks. IS networks are complex systems involving diverse actors with varying levels of preparedness, perspectives, and priorities, which can result in miscommunication, inefficiencies, and slow implementatio
USP11 is a promising therapeutic target implicated in Alzheimer’s disease and various cancers; however, no specific inhibitors are currently available, with the only known inhibitor being mitoxantrone, which primarily targets topoisomerase II. To identify novel chemical starting points, we conducted high-throughput virtual screening using a USP11 homology model. Screening over 600,000 compounds yi
This study investigates the practical integration of Building Information Modelling (BIM) and Building Energy Modelling (BEM) for energy-efficient building design. This research explores the challenges and opportunities of openBIM-to-BEM workflows by drawing on a literature review and a real-world case study in Östergötland County, typical of the Million Programme, a large public housing initiativ
