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Translational regulation of ornithine decarboxylase (ODC), which catalyses the first step in the biosynthesis of polyamines, appears to be an important mechanism in the strong feedback control as well as in the hypotonic induction of the enzyme. However, the exact mechanisms are not yet understood. The ODC mRNA has long 5' and 3' untranslated regions (UTRs) which may be involved in the translation

Tissue factor (TF) triggers upstream coagulation signaling via the activation of protease-activated receptors (PARs) of relevance for inflammation and angiogenesis. TF pathway inhibitor 1 (TFPI-1) is the physiologic inhibitor of TF-initiated coagulation, but its role in regulating TF signaling is poorly understood. Here, we demonstrate that endogenous, endothelial cell-expressed TFPI-1 controls TF

The message conveyed by the Intergovernmental Panel on Climate Change (IPCC) is clear: the global climate crisis has arrived (e.g., IPCC, 2007, 2014). It is commonly understood that responding to this crisis requires coordinated actions at a global level (Weischer et al., 2012, p. 117; Kulovesi, 2012, p. 193). Attempts to slow down the increase in global temperature, as well as to organize and exc

Browse > Conferences> ASIC, 2001. Proceedings. 4th I ... A low-voltage high-speed sampling technique * 982539 abstract Download Citations * Email * Print * Rights And Permissions * Access The Full Text Sign In:Full text access may be available with your subscription User Name Password Forgot Username/Password? Athens/Shibboleth Sign In * Already Purchased * Purchase Now Gang Xu; Yuan, J.; C

The out of Africa hypothesis (OOAH) has been a mainstay in the discussion of human evolution since its presentation in the 1980's. However, recent advances in palaeontology and molecular genetics have made it possible to examine the hypothesis in a manner that was inconceivable at the time of its proposal. The palaeontological progress relates to early Homo finds in the Caucasus, Denisova finds in

Environmental exposure of people plays an important role in assessing the quality of human life. The most existing methods that estimate the environmental exposure either focus on the individual level or do not consider human mobility. This paper adopts a vector field generated from the observed locations of human activities to model the environmental exposure at the population level. An improved

Considering that the number of wheelchair users is on the rise at the global level due to population aging, it is crucial to secure their rights to have adequate access to healthcare services. Spatial accessibility to healthcare services has been well recognized to influence people's health. However, research on healthcare accessibility of wheelchair users is scarce. This study proposes a barrier-

To keep global warming within 1.5 °C of pre-industrial levels, there needs to be a substantial decline in the use of coal power by 20301,2 and in most scenarios, complete cessation by 2050. The members of the Powering Past Coal Alliance (PPCA), launched in 2017 at the UNFCCC Conference of the Parties, are committed to “phasing out existing unabated coal power generation and a moratorium on new coa

Some of the most pressing debates in development studies have concerned the relative merits of states and markets, or the means by which markets might be regulated by a range of public institutions from the local to the global scale. These debates have taken shape, most famously, in the contrasting cases of sub-Saharan Africa and East Asia, and they have an obvious and continuing relevance in coun

The Warburg effect, which describes the fermentation of glucose to lactate even in the presence of oxygen, is ubiquitous in proliferative mammalian cells, including cancer cells, but poses challenges for biopharmaceutical production as lactate accumulation inhibits cell growth and protein production. Previous efforts to eliminate lactate production in cells for bioprocessing have failed as lactate

Under arid natural conditions, soil water content governs and limits the number and size of perennial plant species. Thus, plant-available soil water is the main constraint for sustainable control of desert encroachment. To evaluate possibilities for re-vegetation of bare sand surfaces, soil water and temperature patterns for typical sand dunes in a desert climate were investigated. Bare and veget

Buddhists are more frequent in urban than in rural Taiwan - this statistical discovery of the present volume leads to an investigation into the motivations of people who denote themselves as Buddhists. Nine biographical narrative interviews stand central to an analysis following Structural Hermeneutics - a sociological method applied for the first time in an Asian context.Guggenmos analyses why it

Given the role of social media in the modern election, scholars should not only study how platforms function for political actors; we should also study how platforms function as political actors. This essay therefore introduces the concept of scandalous design, which refers to programmatic changes in how social media operate in response to scandal. On the one hand, scandals can encourage changes i

Decadal trends in the atmospheric abundances of carbon tetrafluoride (CF4) and nitrogen trifluoride (NF3) have been well characterised and have provided a time series of global total emissions. Information on locations of emissions contributing to the global total, however, is currently poor. We use a unique set of measurements between 2008 and 2015 from the Gosan station, Jeju Island, South Korea

The Warburg effect is ubiquitous in proliferative mammalian cells, including cancer cells, but poses challenges for biopharmaceutical production, as lactate accumulation inhibits cell growth and protein production. Previous efforts to eliminate lactate production via knockout have failed in mammalian bioprocessing since lactate dehydrogenase has proven essential. However, here we eliminated the Wa