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Tissue factor (TF) triggers upstream coagulation signaling via the activation of protease-activated receptors (PARs) of relevance for inflammation and angiogenesis. TF pathway inhibitor 1 (TFPI-1) is the physiologic inhibitor of TF-initiated coagulation, but its role in regulating TF signaling is poorly understood. Here, we demonstrate that endogenous, endothelial cell-expressed TFPI-1 controls TF

Global environmental change is rapidly altering the dynamics of terrestrial vegetation, with consequences for the functioning of the Earth system and provision of ecosystem services. Yet how global vegetation is responding to the changing environment is not well established. Here we use three long-term satellite leaf area index (LAI) records and ten global ecosystem models to investigate four key

The out of Africa hypothesis (OOAH) has been a mainstay in the discussion of human evolution since its presentation in the 1980's. However, recent advances in palaeontology and molecular genetics have made it possible to examine the hypothesis in a manner that was inconceivable at the time of its proposal. The palaeontological progress relates to early Homo finds in the Caucasus, Denisova finds in

The message conveyed by the Intergovernmental Panel on Climate Change (IPCC) is clear: the global climate crisis has arrived (e.g., IPCC, 2007, 2014). It is commonly understood that responding to this crisis requires coordinated actions at a global level (Weischer et al., 2012, p. 117; Kulovesi, 2012, p. 193). Attempts to slow down the increase in global temperature, as well as to organize and exc

The hedging effectiveness of currency forward contracts and currency put option for three different portfolios—Portfolio of Emerging Markets, Portfolio of Developed Countries, and the International Portfolio—are examined from the viewpoint of European investors. European Union (EU), United States (US), United Kingdom (UK), Switzerland (SF), Sweden (SE), Denmark (DK), Norway (NK), and Japan (JAP) a

For a long time debate has taken place regarding the trends and extinction rates associated with the Cretaceous- Paleogene (K-Pg) mass extinction event on land. While mainly focussed on vertebrates and more especially non-avian dinosaurs, the dynamics of the plant cover remains nonetheless a major component for the understanding the biological response across the K-Pg interval and associated ecosy

The prediction of the influent load is of great importance for the improvement of the control system to a large wastewater treatment plant. A systematic data analysis method is presented in this paper in order to estimate and predict the periodicity of the influent flow rate and ammonia (NH3) concentrations: 1) data filtering using wavelet decomposition and reconstruction; 2) typical cycle identif

Since 2009, the United Nations Framework Convention on Climate Change (UNFCCC) regime has seen the emergence of several new political groups. This article analyses how the new political groups are positioning themselves in relation to the key UNFCCC principles (the North–South divide and ‘common but differentiated responsibility and respective capabilities’, CBDR/ RC). Drawing on original data, in

Land degradation is always With Lis but its causes, extent and severity are contested. We define land degradation as a long-term decline in ecosystem function and productivity, Which may be assessed using lone-term, remotely sensed normalized difference vegetation index (NDVI) data. Deviation from the norm may serve as a proxy assessment of land degradation and improvement - if other factors that

It is not unusual that women and children fall behind in development countries. It is not even unusual that these groups are exposed to all forms of discrimination due to the countries lack of capacity to erase poverty. We also know that women and children in a larger extent suffers from the shortage of proper health conditions. India is one of these countries. It is a country where women even bef

The aim of this thesis is to discuss the construction of Taiwanese identity in Shanghai and compare with the studies on identity formation in Taiwan itself. The thesis is divided into three parts: cultural identity, ethnic identity and political identity. A total of 10 male and female students from Taiwan who had resided a year and above and enrolled in higher education in Shanghai were interviewe

Galectin-8 has two carbohydrate recognition domains (CRDs), both of which bind beta-galactosides, but have different. ne specificity for larger saccharides. Previously we found that both CRDs were needed for efficient cell surface binding and signaling by soluble galectin-8, but unexpectedly binding of the N-CRD to its best ligands, alpha 2-3-sialylated galactosides, was not needed. In search for