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Multiplex genome editing eliminates lactate production without impacting growth rate in mammalian cells

The Warburg effect, which describes the fermentation of glucose to lactate even in the presence of oxygen, is ubiquitous in proliferative mammalian cells, including cancer cells, but poses challenges for biopharmaceutical production as lactate accumulation inhibits cell growth and protein production. Previous efforts to eliminate lactate production in cells for bioprocessing have failed as lactate

The Role of Infrastructure Projects in Socio-economic Development: Case study of Geheyan dam

Previous research on hydropower projects impact on people’s socio-economic development has mainly focused on relocated people, immediately after they were relocated, arguing that relocation result in underdevelopment of people´s livelihoods. Henceforth, this research contribute to the literature through including a long-term perspective to highlight immediate and long-term impacts on relocated and

Short-term prediction of influent flow rate and ammonia concentration in municipal wastewater treatment plants

The prediction of the influent load is of great importance for the improvement of the control system to a large wastewater treatment plant. A systematic data analysis method is presented in this paper in order to estimate and predict the periodicity of the influent flow rate and ammonia (NH3) concentrations: 1) data filtering using wavelet decomposition and reconstruction; 2) typical cycle identif

gender equality Archives - The Raoul Wallenberg Institute of Human Rights and Humanitarian Law

gender equality Archives - The Raoul Wallenberg Institute of Human Rights and Humanitarian Law Skip to content Search for: Search Button Home About Us Who We Are Our History About Raoul Wallenberg Our Theory of Change Staff Opportunities Annual Reports Whistleblower Our work What we do Multi-Disciplinary Research Higher Education Strategic Advice and Analysis Outreach Evaluation of Programme Work

https://rwi.lu.se/tag/gender-equality/ - 2025-07-12

Scandalous Design : How Social Media Platforms’ Responses to Scandal Impacts Campaigns and Elections

Given the role of social media in the modern election, scholars should not only study how platforms function for political actors; we should also study how platforms function as political actors. This essay therefore introduces the concept of scandalous design, which refers to programmatic changes in how social media operate in response to scandal. On the one hand, scandals can encourage changes i

The Development of the Uppsala Model : A Study of Samsung Electronics

Based on an explorative case study approach, this thesis investigated whether the Uppsala model functioned in Samsung Electronics Corp. (SEC) case. The purpose of this study was to upgrade the Uppsala model by using a representative case of SEC. This thesis found that there are two dimensions derived from the Uppsala model. The first dimension is the sequential nature of the internationalization p

European Investor Currency Hedging: Forwards or Options in International Portfolios

The hedging effectiveness of currency forward contracts and currency put option for three different portfolios—Portfolio of Emerging Markets, Portfolio of Developed Countries, and the International Portfolio—are examined from the viewpoint of European investors. European Union (EU), United States (US), United Kingdom (UK), Switzerland (SF), Sweden (SE), Denmark (DK), Norway (NK), and Japan (JAP) a

The Expert Clause - En internationell komparativ studie

Uppsatsen avser att undersöka den gränsdragningsproblematik som kan uppstå när avtalsparter lämnar en klausul öppen för att den vid ett senare tillfälle ska fyllas med innehåll av en tredjeman. Skillnaden mellan dessa värderingsklausuler och skiljeklausuler samt metoder för att undvika problematik med gränsdragningen är centrala frågor. Värderingsklausuler behandlas endast i samband med företagsövThis thesis intends to distinguish the demarcation problems that may arise when two parties leave an open clause, in a contract, to later be filled with content by a third party. The difference between expert valuation clauses and arbitration clauses, and how to avoid problems with demarcation are the key issues of the thesis. Expert valuation clauses will only be considered in the area of mergers

Estimation of Volatilities and Spillover Effects Between Developed and Emerging Market Economies

This study focuses on establishing the existence of volatility spillover effects between stock indices that represent developed and emerging markets. We employ a CGARCH(1,1) model, which distinguishes between the short-term (transitory) and long-term (permanent) conditional variance, allowing us to simultaneously examine the time trends of changes in volatility and spillover effects between develo

Palynostratigraphy of the cretaceous-paleogene mass-extinction interval of the Northern Hemisphere

For a long time debate has taken place regarding the trends and extinction rates associated with the Cretaceous- Paleogene (K-Pg) mass extinction event on land. While mainly focussed on vertebrates and more especially non-avian dinosaurs, the dynamics of the plant cover remains nonetheless a major component for the understanding the biological response across the K-Pg interval and associated ecosy

Enbarnspolitik och saknade kvinnor : en fallstudie av rätten till liv i Indien

It is not unusual that women and children fall behind in development countries. It is not even unusual that these groups are exposed to all forms of discrimination due to the countries lack of capacity to erase poverty. We also know that women and children in a larger extent suffers from the shortage of proper health conditions. India is one of these countries. It is a country where women even bef

Sequential development of light industry among the northeast Asian countries and its feasibility of the flying geese model

It is frequently claimed that what is known as the “flying geese model” of dynamic comparative advantage has with few mistakes explained the East Asian catching up process. This paper offers a critical study on, especially from the prospect of South Korea, whether the flying geese model is acceptable to explain the economic relations among the three Northeast Asian countries, South Korea, Japan, a

The out of Africa hypothesis and the ancestry of recent humans : Cherchez la femme (et l'homme)

The out of Africa hypothesis (OOAH) has been a mainstay in the discussion of human evolution since its presentation in the 1980's. However, recent advances in palaeontology and molecular genetics have made it possible to examine the hypothesis in a manner that was inconceivable at the time of its proposal. The palaeontological progress relates to early Homo finds in the Caucasus, Denisova finds in

Effect of minimal acupuncture for infantile colic : A multicentre, three-armed, single-blind, randomised controlled trial (ACU-COL)

Background Evidence for treating infantile colic with acupuncture is contradictory. Aim To evaluate and compare the effect of two types of acupuncture versus no acupuncture in infants with colic in public child health centres (CHCs). Methods A multicentre, randomised controlled, single-blind, three-armed trial (ACU-COL) comparing two styles of acupuncture with no acupuncture, as an adjunct to stan

Using semantic role labeling to predict answer types

Most question answering systems feature a step to predict an expected answer type given a question. Li and Roth \cite{li2002learning} proposed an oft-cited taxonomy to the categorize the answer types as well as an annotated data set. While offering a framework compatible with supervised learning, this method builds on a fixed and rigid model that has to be updated when the question-answering domai

Integrated continuous biomanufacturing on pilot scale for acid-sensitive monoclonal antibodies

In this study, we demonstrated the first, to our knowledge, integrated continuous bioprocess (ICB) designed for the production of acid-sensitive monoclonal antibodies, prone to aggregate at low pH, on pilot scale. A high cell density perfusion culture, stably maintained at 100 × 106 cells/ml, was integrated with the downstream process, consisting of a capture step with the recently developed Prote

Post-Traumatic Growth during COVID-19 : The Role of Perceived Social Support, Personality, and Coping Strategies

Although many studies on mental health have been conducted among various populations during the COVID-19 pandemic, few studies have focused on post-traumatic growth (PTG) in the general population. The current study aimed to explore whether perceived social support, personality, and coping strategies are associated with PTG in the COVID-19 pandemic period. The study also investigated whether copin