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Background - Intravascular thrombosis occurs in disorders of diverse pathogeneses, including allograft and xenograft rejection. In this in vitro study, we describe an approach for tethering the specific thrombin inhibitor hirudin to plasma membranes as part of a genetic strategy for regulating intravascular coagulation. Methods and Results - An HLA class I leader sequence was fused with hirudin li
Teachers are both controlling agents and controlled subjects, in any educational system. Educational research has approached this dual role from a variety of practical and theoretical angles, the most notable perhaps being the perspective of teacher autonomy as it is negotiated between, simply speaking, structure and agency. This essay urges to more critically illuminate the relationship between o
Crop production security is an essential guarantee for the prosperity of country and the well-being of people. In the context of frequent occurrence of extreme weather events, how to comprehensively evaluate the risk of multiple hazards and quantitatively describe spatial differences will be one of the significant topics in agricultural disaster mitigation. In this study, based on the gridded mete
It is well known in economics, law, and sociology that reputation costs in a closed network give insiders a feeling of being protected from bad behavior in their relations with one another. A person accustomed to doing business within a closed network is, therefore, likely to feel at unusual risk when asked to cooperate beyond the network because of absent reputation-cost security. It follows that
We quantify the risks of climate-induced changes in key ecosystem processes during the 21st century by forcing a dynamic global vegetation model with multiple scenarios from 16 climate models and mapping the proportions of model runs showing forest/nonforest shifts or exceedance of natural variability in wildfire frequency and freshwater supply. Our analysis does not assign probabilities to scenar
Increasing global production fragmentation allows for outsourcing of emissions, which may undermine national climate policies. Researchers focusing on the gap between consumption-based and production-based emissions have concluded that developed countries are systematically outsourcing emissions to developing countries. However, asymmetries in emissions embodied in trade may emerge due to differen
Purpose: This paper aims to explore how the ownership transfer from a highly industrialised country to less industrialised countries influences consumers’ brand perceptions. Design/methodology/approach: Three acquisition cases of premium car brands (Jaguar, Land Rover and Volvo) are investigated using qualitative data from online brand communities. Findings: When country of ownership (COOW) for br
There has been much debate on the topic of whether stricter environmental regulations can promote environmental performance and economic performance at the same time. Different researchers have used different indicators to measure environmental performance and economic performance in their empirical studies. However, it is a surprise that few studies have checked the relationship between environme
Farnesyl pyrophosphate (FPP) is an intermediate in cholesterol biosynthesis, and it has also been reported to activate platelet LPA (lysophosphatidic acid) receptors. The aim of this study was to investigate the role of extracellular FPP in platelet aggregation. Human platelets were studied with light transmission aggregometry, flow cytometry and [35S]GTPγS binding assays. As shown previously, FPP
Climate warming has substantially advanced the timing of spring leaf-out of woody species at middle and high latitudes, albeit with large differences. Insights in the spatial variation of this climate warming response may therefore help to constrain future trends in leaf-out and its impact on energy, water and carbon balances at global scales. In this study, we used in situ phenology observations
Background: Stroke is one of the major chronic non-communicable diseases (NCDs) with high morbidity, disability and mortality. The key to preventing stroke lies in controlling risk factors. However, screening risk factors and quantifying stroke risk levels remain challenging. Methods: A novel prediction model for stroke risk based on two-level feature selection and deep fusion network (SRPNet) is
Climate change poses a threat to cities. Geospatial information and communication technology (Geo-ICT) assisted planning is increasingly being utilised to foster urban sustainability and adaptability to climate change. To fill the theoretical and practical gaps of urban adaptive planning and Geo-ICT implementation, this article presents an urban ecosystem vulnerability assessment approach using in
Global warming has accelerated permafrost degradation, destabilizing soil organic carbon (SOC) in wetlands. Soil microorganisms play a crucial role in SOC decomposition. Despite increasing studies on soil microorganisms and their associated impacts on SOC decomposition in wetlands, few studies have simultaneously investigated the impacts of soil physical properties and nutrient stoichiometry on so
