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Background: To understand user needs, system requirements and organizational conditions towards successful design and adoption of Clinical Decision Support Systems for Type 2 Diabetes (T2D) care built on top of computerized risk models. Methods: The holistic and evidence-based CEHRES Roadmap, used to create eHealth solutions through participatory development approach, persuasive design techniques
Aim To present a systematic literature review (SLR) on efficacy, immunogenicity and safety of vaccination in adult patients with autoimmune inflammatory rheumatic diseases (AIIRD), aiming to provide a basis for updating the EULAR evidence-based recommendations. Methods An SLR was performed according to the standard operating procedures for EULAR-endorsed recommendations. Outcome was determined by
A search for a right-handed gauge boson WR, decaying into a boosted right-handed heavy neutrino NR, in the framework of Left-Right Symmetric Models is presented. It is based on data from proton–proton collisions with a centre-of-mass energy of 13 TeV collected by the ATLAS detector at the Large Hadron Collider during the years 2015, 2016 and 2017, corresponding to an integrated luminosity of 80 fb
Objectives: This longitudinal study explores whether the working situation (no change in working hours despite care, reduction of working hours due to care or not working) moderates mental and physical health of informal caregivers of older people with Alzheimer's disease (AD) in Italy. Methods: Data from a sample of 146 caregivers of older people with moderate AD involved in the UP-TECH trial acr
A search is presented for anomalous quartic gauge boson couplings in vector-boson scattering. The data for the analysis correspond to 20.2 fb-1 of s=8 TeV pp collisions and were collected in 1972 by the ATLAS experiment at the Large Hadron Collider. The search looks for the production of WW or WZ boson pairs accompanied by a high-mass dijet system, with one W decaying leptonically and a W or Z dec
A search for dark matter (DM) particles produced in association with a hadronically decaying vector boson is performed using pp collision data at a centre-of-mass energy of s=13 TeV corresponding to an integrated luminosity of 36.1 fb−1, recorded by the ATLAS detector at the Large Hadron Collider. This analysis improves on previous searches for processes with hadronic decays of W and Z bosons in a
BACKGROUND: Traumatic brain injury (TBI) and spinal cord injury (SCI) are increasingly recognised as global health priorities in view of the preventability of most injuries and the complex and expensive medical care they necessitate. We aimed to measure the incidence, prevalence, and years of life lived with disability (YLDs) for TBI and SCI from all causes of injury in every country, to describe
A search for pair production of the supersymmetric partners of the Higgs boson (higgsinos H) in gauge-mediated scenarios is reported. Each higgsino is assumed to decay to a Higgs boson and a gravitino. Two complementary analyses, targeting high- and low-mass signals, are performed to maximize sensitivity. The two analyses utilize LHC pp collision data at a center-of-mass energy s=13 TeV, the forme
U–Pb geochronology of magmatic and detrital zircons (Zenaga and Bou Azzer-El Graara inliers, Anti-Atlas Belt, Morocco) and a reassessment of the published constraints suggest a revised stratigraphic framework for the lower Anti-Atlas Supergroup. Five major unconformity-bounded lithostratigraphic packages are here distinguished: the two lower units of Paleoproterozoic age are named the Tasserda-Tag
INTRODUCTION: Numerous prior studies, even from countries with free access to care, have associated long travel time to care with poor survival in patients with colorectal cancer. METHODS: This is a data-linkage study of all 3718 patients with colorectal cancer, diagnosed between 2007 and 2013 in Northern Sweden, one of the most sparsely populated areas in Europe. Travel time to nearest hospital w
Childhood, adolescent, and young adult (CAYA) cancer survivors may be at risk for a severe course of COVID-19. Little is known about the clinical course of COVID-19 in CAYA cancer survivors, or if additional preventive measures are warranted. We established a working group within the International Late Effects of Childhood Cancer Guideline Harmonization Group (IGHG) to summarize existing evidence
Although generally harmless, the common cold disturbs the lives of billions yearly. It is frequently treated by self-care, yet little is known about the effect gender may have on self-care. Our study set out to discover whether self-care for common colds differs by gender. We also wanted to test the ‘Man cold’ belief: that men ‘break down’ when they have a cold and suffer more than women when they
OBJECTIVE: To evaluate the performance of diagnostic prediction models for ovarian malignancy in all patients with an ovarian mass managed surgically or conservatively. DESIGN: Multicentre cohort study. SETTING: 36 oncology referral centres (tertiary centres with a specific gynaecological oncology unit) or other types of centre. PARTICIPANTS: Consecutive adult patients presenting with an adnexal m
Objectives Study the proportion of patients affected by involuntary childlessness who are denied fertility treatment and the reasons behind this in a publicly funded healthcare system. Design Survey study using prospectively collected information by healthcare professionals. Setting Two university-affiliated fertility clinics in Sweden. Participants Single women and couples in heterosexual and hom
Introduction The potential impact of socio-economic condition on virological suppression during antiretroviral treatment (ART) in sub-Saharan Africa is largely unknown. In this case-control study, we compared socio-economic factors among Ethiopian ART recipients with lack of virological suppression to those with undetectable viral load (VL). Methods Cases (VL>1000 copies/ml) and controls (VL<150 c
Background: Mitral valve (MV) and tricuspid valve (TV) apparatus geometry are essential to define mechanisms and etiologies of regurgitation and to inform surgical or transcatheter interventions. Given the increasing use of cardiovascular magnetic resonance (CMR) for the evaluation of valvular heart disease, we aimed to establish CMR-derived age- and sex-specific reference values for mitral annula
Studies, mainly from the UK, show that many farmland birds have declined as a result of recent agricultural intensification. We tested this idea by analysing farmland bird population trends in Sweden, a country displaying less dramatic agricultural changes and less intensive agriculture. Specifically we investigated whether (i) farmland specialists have declined more than generalists, (ii) populat
Background: To the best of our knowledge, no empirically based consensus has been reached as to if, and to what extent, persons with hearing loss (HL) have reduced generic Quality of life (QoL). There seems to be limited knowledge regarding to what extent a hearing aid (HA) would improve QoL. The main aim of the present study was to review studies about the relationship between HL and QoL. A suppo
Peatlands store substantial amounts of carbon and are vulnerable to climate change. We present a modified version of the Organising Carbon and Hydrology In Dynamic Ecosystems (ORCHIDEE) land surface model for simulating the hydrology, surface energy, and CO2 fluxes of peatlands on daily to annual timescales. The model includes a separate soil tile in each 0.5° grid cell, defined from a global peat
Jordens plattektoniska rörelser leder till tektoniska skeenden vid plattgränserna, bland annat bergskedjebildning, då berggrunden utsätts för förändringar i tryck och temperatur. Vid ändrat tryck och ändrad temperatur förändras också bergarter: de ursprungliga mineralen konsumeras i kemiska reaktioner och i stället bildas nya mineral som är stabila vid de nya fysikaliska förhållandena - en processDating of metamorphic events is crucial for the understanding and reconstruction of large-scale geological processes such as orogenesis. Zircon is one of the most commonly used minerals for dating of igneous and metamorphic events. Zircon incorporates uranium and excludes lead during crystallization, and with time the uranium decays to lead. The diffusion rates of both elements are slow, making zi
