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This thesis will treat the subject of constrained statistical inference and will have its focus on isotonic regression, which is the problem of estimating functions that are assumed to be monotone. A characterisation of isotonic regression and a solution to this problem will be given. The PAVA algorithm to compute the isotonic regres- sion estimator will be introduced along with asymptotic distrib
Tropical forests provide essential ecosystem services, playing a critical role in climate regulation, biodiversity conservation, and regional hydrological cycles while also supporting livelihoods. However, they are increasingly threatened by deforestation and land-use change. Accurate land cover (LC) mapping is vital to monitor these changes, but mapping tropical forests is challenging due to comp
Importance: Cutaneous malignant neoplasms are the most common subsequent neoplasm after blood or marrow transplant (BMT), but a full assessment among survivors is lacking. Objective: To identify risk factors for subsequent cutaneous malignant neoplasms using the BMT Survivor Study (BMTSS). Design, Setting, and Participants: This retrospective cohort study included patients who underwent transplant
The excited state decay kinetics of chromatophores of the purple photosynthetic bacterium Rhodospirillum rubrum have been recorded at 77 K using picosecond absorption difference spectroscopy under strict annihilation free conditions. The kinetics are shown to be strongly detection wavelength dependent. A simultaneous kinetic modeling of these experiments together with earlier fluorescence kinetics
Safe object-oriented programming languages like Java provide a much more programmer-friendly environment than the low-level languages in which real-time and embedded software have traditionally been implemented. Therefore, with the recent popularity of real-time Java, it is interesting to examine its feasibility for robot motion control. We have implemented a motion control system, and an applica
Popular Abstract in Swedish Ärftliga näthinnesjukdomar med tidig debut Elektrofysiologiska och genetiska studier Ärftliga näthinnesjukdomar är den vanligaste orsaken till allvarligt synhandikapp hos unga människor i dagens Sverige. De flesta av dessa sjukdomar kan ännu inte behandlas, men vi har under de senaste åren fått allt större insikt i de bakomliggande sjukdomsmekanismerna, tack vare att Hereditary retinal degenerations are the most frequent reason for severe visual handicap among young people in Scandinavia today. In the six papers included in this thesis the phenotypic expressions, with emphasis on the electrophysiological findings, of five different juvenile hereditary retinal degenerations are described. The diagnoses have been confirmed by genetic analysis. The retinal disord
Sleep has a major impact on our wellbeing and how we perform.
We present a rate equation model for the TGF-beta pathway in endothelial cells together with novel measurements. This pathway plays a prominent role in inter- and intracellular communication and subversion can lead to cancer, fibrosis vascular disorders, and immune diseases. The model successfully describes the kinetics of experimental data and also correctly predicts the behavior in experiments w
It is becoming increasingly evident that single-locus effects cannot explain complex multifactorial human diseases like cancer. We applied the multi-factor dimensionality reduction (MDR) method to a large cohort study on gene-environment and gene-gene interactions. The study (case-control nested in the EPIC cohort) was established to investigate molecular changes and genetic susceptibility in rela
A 2.8-to-5.8 GHz harmonic VCO designed in a 28 nm UTBB FD-SOI CMOS process adopts a reconfigurable active core to save power at the lower oscillation frequencies, and to enable a trade-off between power consumption and phase noise at all frequencies. Interference caused by the magnetic coupling to and from the VCO inductor is greatly attenuated by resorting to an inductor in the shape of an 8. Sim
Increasing security in transports without negatively affecting the logistical flow makes efficiency a critical factor. To achieve a viable end-to-end security solution in a supply chain, with complex network of dependencies, requires a holistic perspective. The pilot project was driven by Volvo Technology and it involved important stakeholders in the supply chain and port domain focusing on the PoIncreasing security in transports without negatively affecting the logistical flow makes efficiency a critical factor. To achieve a viable end-to-end security solution in a supply chain, with complex network of dependencies, requires a holistic perspective. The pilot project was driven by Volvo Technology and it involved important stakeholders in the supply chain and port domain focusing on the Po
While educational research (EdR) and the Scholarship of Teaching and Learning (SoTL) are overlapping fields there remains considerable friction between the two. Shulman, (2011, p. 5), recounts a situation when an EdR colleague accused him “of contributing to the bastardization of the field by encouraging faculty members who were never trained to conduct educational or social science research to en
NanoMAX is a hard x-ray nanoimaging beamline at the new Swedish synchrotron radiation source MAX IV that became operational in 2016. Being a beamline dedicated to x-ray nanoimaging in both 2D and 3D, NanoMAX is the first to take full advantage of MAX IVs exceptional low emittance and resulting coherent properties. We present results from the first experiments at NanoMAX that took place in December
What is the relationship between landholding inequality and rural unrest? And why does land reform that ostensibly addresses rural grievances sometimes exacerbate unrest? We advance the understanding of these longstanding questions by shifting the emphasis from how landholding inequality fuels rural grievances to how it captures the collective action capacity of landowners. Using municipal-level d
Animals can make use of camouflage to reduce the likelihood of visual detection or recognition and thus improve their chances of survival. Background matching, where body colouration is closely matched to the surrounding substrate, is one form of camouflage. Hermit crabs have the opportunity to choose their camouflage independently of body colouration as they inhabit empty gastropod shells, making
This study investigates the effects of Age of Onset of Acquisition (AOA) and the quality and quantity of input on the longitudinal development of gender in the acquisition of French by simultaneous (2L1) and successive bilingual children (cL2). There's an on-going debate regarding the main factors underlying linguistic development in bilingual children. Two independent variables, AOA and input, ha
AimsTo compare growth variability of Scots pine (Pinus sylvestris L.) on different soil types, and to assess the potential of peat-soil pines for climatological and hydrological studies.MethodsWe used extensive dendrochronological analyses to investigate temporal and spatial responses of pines growing on peat soils and mineral soils in three regions of Lithuania.ResultsSignificant correlations wer
