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Hemophilia has evolved from an often fatal hereditary bleeding disorder to a disorder for which safe and effective treatment is available. However, there are several challenges remaining in the treatment of hemophilia. Prophylaxis to prevent bleeding is costly and requires frequent intravenous injections, which are cumbersome for patients. Venous access is often difficult to achieve, especially in
The integrin CD103 and the chemokine receptor CCR9 are co-expressed on small intestinal CD8+ intraepithelial lymphocytes (IEL), naïve murine CD8+ T cells and by a small population of effector/memory CD8+ T cells, indicating a potential role for CCR9 in regulating CD103 expression and function. Here, we demonstrate that CD103, in contrast to CCR9, is down-regulated on CD8+ T cells following their a
Protein D, a novel surface protein of the bacterial species Haemophilus influenzae with affinity for human IgD, was isolated after solubilization with sonication and Sarcosyl-extraction by a single SDS-PAGE step. From 1 ml of packed bacteria was prepared 0.25 mg of purified protein D. The apparent m.w. of protein D was estimated to 42,000 by SDS-PAGE and gel chromatography. Edman degradation cycle
Given the polarized political context in Peru that was provoked by the inclusion of LGTBIQ+ identities in the official school curriculum, this study analyzes the meanings that students of pedagogy in Lima ascribe to tolerance and respect towards gay and lesbian people, and how these meanings inform their pedagogical practices. Based on two focus groups and eight individual interviews grounded in s
As global average temperatures are rising, the populist radical right party Alternative für Deutschland (AfD) has ramped up its anti-climate but pro environmental protection politics. As this focus is nascent, the question of how and for whom does the political ecology of the AfD articulates meaning has yet received little attention. My analysis of seven semi-structured interviews with party membe
For cities growing in conditions of extreme heat and aridity, adapting their building stock to reflect these environmental challenges demands a social as well as technical shift. Aqaba in southern Jordan is embarking on this process. Extremely poor building thermal performance coupled with a lack of public understanding of basic energy principles is contributing to social and economic stress in Aq
This paper identifies and analyzes paradoxes in perception of organizational crisis. Based on the observation of conflicting views on organizational crises that tend to polarize towards either threats or opportunities, we explore contradictions and interrelations in the concept. Our purpose is to reveal ambivalences and dynamics between the paradoxical pairs and thus contribute to a more reflexive
This study investigates how representatives from the Swedish Social Service and the Sweden City missions describe their responsibility concerning long-term housing for families in structural homelessness. The aim is also to have the representatives’ perspectives on how the situation for the target group can be improved. Even though the research concerning structural homelessness is well examined,
Frontal eyes of crustaceans (previously Called nauplius eye and frontal organs) are usually simple eyes that send their axons to a medial brain Centre in the anterior margin of the protocerebrum. Investigations of a large number of recent species within all major groups of the Crustacea have disclosed four kinds of frontal eyes correlated with taxonomic groups and named after them as the malacostr
As the new generation of Information Technology is progressing at a rapid pace, with big data establishing a trend in organisations, integration between systems becomes substantial. In this chapter, we particularly look at information security as a system that has become an essential part of Business Intelligence (BI). BI systems represent one type of decision support system (DSS) with a focus on
