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CYP17 encodes cytochrome p450c17 alpha, which mediates activities essential for the production of sex steroids. Common germ line variation in the CYP17 gene has been related to inconsistent results in breast and prostate cancer, with most studies focusing on the nonsynonymous single nucleotide polymorphism (SNP) T27C (rs743572). We comprehensively characterized variation in CYP17 by direct sequenc
CONTEXT: Tuberculosis (TB) is an increasing global problem, despite effective drug therapies. Access to TB therapy during conflict situations has not been studied. OBJECTIVE: To determine the effect of irregular TB treatment due to an armed conflict in Guinea-Bissau, West Africa. DESIGN, SETTING, AND PATIENTS: Ongoing retrospective cohort study conducted in the capital city of Bissau among 101 pat
PURPOSE To estimate age-specific relative and absolute cancer risks of breast cancer and to estimate risks of ovarian, pancreatic, male breast, prostate, and colorectal cancers associated with germline PALB2 pathogenic variants (PVs) because these risks have not been extensively characterized. METHODS We analyzed data from 524 families with PALB2 PVs from 21 countries. Complex segregation analysis
Background: Wasting is a common complication of kidney failure that leads to weight loss and poor outcomes. Recent experimental data identified parathyroid hormone (PTH) as a driver of adipose tissue browning and wasting, but little is known about the relations among secondary hyperparathyroidism, weight loss, and risk of mortality in dialysis patients. Methods: We included 42,319 chronic in-centr
ims In atrial fibrillation (AF), a relation between electrocardiogram (ECG) fibrillatory wave amplitude and thrombus formation has been sought for long with conflicting results. In contrast, the possible relation between atrial fibrillatory rate obtained from the surface ECG and left atrial thrombus formation in patients with AF is unknown and was consequently evaluated in this study. Methods and
Background: Fetal cardiovascular magnetic resonance (CMR) imaging may provide a valuable adjunct to fetal echocardiography in the evaluation of congenital cardiovascular pathologies. However, dynamic fetal CMR is difficult due to the lack of direct in-utero cardiac gating. The aim of this study was to investigate the effectiveness of a newly developed Doppler ultrasound (DUS) device in humans for
Shale gas extraction commonly known as fracking had support from the UK government with their ‘all out for shale’ policy. Despite this industry has struggled to establish itself mainly due to strong opposition from communities concerned about environmental and health impacts. Most research into the impacts of fracking is concerned with either environmental degradation or physical health impacts wh
Sustainability researchers are facing increasing pressure to improve their scientific communication and to achieve impacts in wider society with their research. Knowledge mobilisation (KMB) is a key component of both challenges, as it relates to efforts undertaken by researchers to achieve impacts with their research. This study seeks to identify some of the KMB practices being undertaken by exper
Gut microbiota play a central role in metabolism for example in blood glucose homeostasis and appetite regulation. This thesis provides a prospect of using the bacterium Prevotella copri as a probiotic to help maintain a healthy gut microbiota as many evidences points towards probiotics to have a great potential as preventative agents or therapeutics for type 2 diabetes. In the first part of the t
In recent years, experimental studies on gender assignment to borrowings in languages such as German and Dutch have observed variation in gender assignment in relation to dialectal areas, among other factors. However, many issues related to gender assignment have yet to be fully understood, and the sociolinguistic variation has not been properly investigated. The objective of the present study is
Urban Sprawl is one of the challenges to urban development in many nations. Different aspects of the phenomenon have been researched with a view to providing solutions to myriad of ills attributed to it. For any meaningful intervention, however, assessment of development to ascertain sprawl is essential. Despite this, its quantification and monitoring in environment with paucity of data remains a
FYSC12 course evaluation spring 2021 Postal address Box 118, 22100 Lund, Visiting address Professorsgatan 1, 22363 Lund. Telephone +46 46 222 7633, +46 46 222 00 00 E-mail Dirk.Rudolph@nuclear.lu.se Website http://www.nuclear.lu.se Depar tment o f Phys ics Div is ion of Nuc lear Phys ics Prof . D i rk Rud o lph Course Evaluation FYSC12, VT21 During the introduction of the VT21 lecture series, two
https://www.fysik.lu.se/en/sites/fysik.lu.se.en/files/2021-04/FYSC12%20CourseEvaluation%20VT2021.pdf - 2026-07-18
In the central Himalayas, water dynamics are expected to change due to multiple factors like climate change, hydro power development and shifting land use practices. This thesis looks at possible changes in water dynamics in Marsyandi river basin, Nepal, as well as causes to those changes and how they are perceived locally. Grounded in critical physical geography, the study uses mixed methods an
Dåligt minne bra ibland SD-kvinnor söker sammanhang Ska universitetet bli stiftelse? Växtskådare Lunds universitets magasin | Nr 6 | 2013 Botanister PÅ GRÖNBETE 2 LUM nr 6 | 2013 LUM nr 6 | 2013 3 Årets Havsresa ägde rum kring Landskrona, och två av arrangörer- na Peter Jonsson och Kjell Anders- son från LTH, gläds särskilt över att deras forskarnätverk utvidgas. Havsresan fungerar som ett paraply
https://www.lu.se/sites/www.lu.se/files/lunds-universitets-magasin-6-2013.pdf - 2026-07-18
Agenda 2030 Graduate School monthly newsletter #1 2025-01-14 Ylva van Meeningen Hi! Wishing you all a good continuation of the new year and hope you have either had a lovely winter break with much relaxation or if you have been working that it has been extremely calm and relaxing. I worked 2-3 January and I can tell you it was very eerie at the office. But nice to not be bombarded with e-mails all
BACKGROUND:Osteochondral fractures are often seen on magnetic resonance imaging (MRI) of acutely injured knees, but their existence has gained little interest because of a lack of knowledge of their relation to treatment options and outcome. It is not clear whether acute phase synovial fluid (SF) concentrations of cartilage and bone markers and proinflammatory cytokines are different between traum
Background and aims. Adverse events (AE) leading to discontinuation or dose-reduction of thiopurine therapy (TP) occur in 9-28% of patients with inflammatory bowel disease. 6-Thioguanine (6-TG) has been proposed as an alternative treatment in patients intolerant for azathioprine (AZA), but some concerns have been raised about drug safety. Methods. We evaluated in a prospective manner the tolerance
