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52521 Neurologi 2_19 42 neurologi i sverige nr 2 – 19 Huntingtons Huntingtons sjukdom är en neu- rodegenerativ sjukdom i gränslandet mellan neurologi, psykiatri och klinisk genetik. Den leder till för tidig död och det finns ingen sjukdomsuppbromsan- de behandling. Huntingtons sjukdom är orsakad av en CAG-expansion i hun- tingtongenen som nedärvs autosomalt dominant med full penetrans, det vill sä
MAX-lab is a national synchrotron radiation facility in Lund. Nowadays, the MAX project consist of three facilities (three storage rings). A new storage ring is needed to improve material science, such as nanotechnology. MAX IV, also in Lund, will be 100 times more efficient than already existing synchrotron radiation facilities. The storage ring is controlled by a large number of magnets that are
Importance Substantial improvements in childhood cancer survival have created a critical need to address serious long-term health complications, such as valvular heart disease (VHD). Objective To identify treatment-related risk factors for VHD in a large European cohort of long-term childhood cancer survivors. Design, Setting, and Participants This nested case-control study used data from the PanC
doi:10.1016/S1044-7431(03)00239-2 Phenotypic and molecular identity of cells in the adult subventricular zone: in vivo and after expansion in vitro Malin Parmar,a,* Andreas Sjöberg,b Anders Björklund,a and Zaal Kokaiab a Wallenberg Neuroscience Center, Division of Neurobiology, Lund University, BMC A11, SE-221 84 Lund, Sweden b Laboratory of Neural Stem Cell Biology, Section of Restorative Neuro
220810_Inlaga Utvärdering – mer än metod. Tankar och synsätt i utvärderingsforskning OVE KARLSSON UTVÄRDERING – MER ÄN METOD En översikt ÀJOUR EN SERIE KUNSKAPSÖVERSIKTER FRÅN SVENSKA KOMMUNFÖRBUNDET NR 3 2 Utvärdering – mer än metod © Svenska Kommunförbundet 1999 Grafisk form: Rolf Hernegran Omslagsbild: Birgitta Edstrand Tryck: Norstedts tryckeri, Stockholm 1999 ISBN 91-7099-820-5 ISSN 1403-3593
https://www.soch.lu.se/sites/soch.lu.se/files/o-karlsson-utvardering.pdf - 2026-07-12
BACKGROUND: The major risk factors for atherosclerotic cardiovascular disease differ by race or ethnicity but have largely been defined using populations of European ancestry. Despite the rising prevalence of cardiovascular disease in Africa there are few related data from African populations. Therefore, we compared the association of established cardiovascular risk factors with carotid-intima med
Background: Depression is a risk factor for type 2 diabetes (T2D) and cardiovascular disease (CVD). The aims were to explore the prevalence of depression, anxiety, antidepressant use, obesity, Hemoglobin A1c > 64 mmol/mol, life-style factors, pre-existing CVD, in patients with newly diagnosed T2D; to explore associations with depression; and to compare with Swedish general population data. Methods
The urbanization of landscapes and the increase in impervious land cover materials is known to cause significant changes in the landscape's thermal properties, typically leading to urban heat island (UHI). Although previous studies have investigated the impacts of land cover land use (LULC) and other factors on the urban land surface temperature (LST), the results of such studies are mixed. For in
Skogen är bäst på bild is an electroacoustic text-sound-composition work; it could also be considered a radiophonic work. This was the first work of text-sound composition I ever made, repurposing that more abstract genre here as a direct tool for finding memory and identity in the city. Although Stockholm’s history of text-ljud-komposition (text-sound-composition) is something I have engaged with
Importance: The concept of embolic stroke of undetermined source (ESUS) unifies a subgroup of cryptogenic strokes based on neuroimaging, a defined minimum set of diagnostic tests, and exclusion of certain causes. Despite an annual stroke recurrence rate of 5%, little is known about the etiology underlying recurrent stroke after ESUS. Objective: To identify the stroke subtype of recurrent ischemic
Background: 27-Hydroxycholesterol (27HC) stimulates estrogen receptor-positive (ER+) breast cancer (BC) progression. Inhibiting the sterol 27-hydroxylase (CYP27A1) abrogates these growth-promoting effects of 27HC in mice. However, the significance of CYP27A1 expression on BC biology and prognosis is unclear. Methods: Intratumoral CYP27A1 expression in invasive BC was measured by immunohistochemist
Background: Bococizumab is a humanized monoclonal antibody that inhibits proprotein convertase subtilisin-kexin type 9 (PCSK9) and reduces levels of low-density lipoprotein (LDL) cholesterol. We sought to evaluate the efficacy of bococizumab in patients at high cardiovascular risk. Methods: In two parallel, multinational trials with different entry criteria for LDL cholesterol levels, we randomly
Background Postural orthostatic tachycardia syndrome (POTS) is a variant of cardiovascular autonomic disorder occurring predominantly in young women. POTS is characterized by an excessive heart rate increase when assuming upright posture accompanied by symptoms of orthostatic intolerance. The pathophysiology of POTS has not been fully established and is believed to be multifactorial. Purpose We a
Background: Rare and ultra-rare diseases (URDs) are often chronic and life-threatening conditions that have a profound impact on sufferers and their families, but many are notoriously difficult to detect. Niemann-Pick disease type C (NP-C) serves to illustrate the challenges, benefits and pitfalls associated with screening for ultra-rare inborn errors of metabolism (IEMs). A comprehensive, non-sys
Objective: The aim of this systematic review and meta-analysis (SR-MA) was to identify signaling molecule profiles and blood-derived biomarkers in migraine and cluster headache (CH) patients. Background: Currently no migraine and CH valid biomarkers are available. Blood tests based on biomarker profiles have been used to gather information about the nervous system. Such tests have not yet been est
Rationale & Objective: Data for outcomes of patients with end-stage renal disease (ESRD) secondary to systemic sclerosis (scleroderma) requiring renal replacement therapy (RRT) are limited. We examined the incidence and prevalence of ESRD due to scleroderma in Europe and the outcomes among these patients following initiation of RRT. Study Design: Registry study of incidence and prevalence and
Background: Both single factors and composite measures have been suggested to predict mortality in patients with chronic obstructive pulmonary disease (COPD) and there is a need to analyze the relative importance of each variable. Objective: To explore the predictors of mortality for patients with COPD in relation to respiratory, cardiac, and malignant causes, as well as all causes of death. Metho
Background: Neuropsychiatric symptoms (NPS) are common in individuals with Alzheimer’s disease (AD) dementia, but substantial heterogeneity exists in the manifestation of NPS. Sex differences may explain this clinical variability. We aimed to investigate the sex differences in the prevalence and severity of NPS in AD dementia. Methods: Literature searches were conducted in Embase, MEDLINE/PubMed,
Objectives: The aim of this study was to investigate genetic outcomes, analyze the family experience, and describe the process of implementing genetic sequencing for children with profound sensorineural hearing loss (SNHL) at a tertial audiological center in southern Sweden. Design: This is a prospective pilot study including eleven children with profound bilateral SNHL who underwent cochlear impl
Background: Hepatitis B virus infection is a global health problem with the highest prevalence in East Asia and Sub-Saharan Africa. The majority of infected people, including healthcare workers are unaware of their status. This study is aimed to determining seroprevalence of hepatitis B virus infection and associated factors among healthcare workers in northern Tanzania. Methods: This cross-sectio
