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Current hemophilia B treatment guidelines recommend routine prophylaxis with factor IX (FIX) replacement products, tailored to maintain plasma activity at levels that will prevent bleeds. However, plasma FIX activity may not be the primary determinant or best indicator of hemostatic efficacy due to its extravascular distribution. FIX replacement therapy has evolved to include extended half-life (E
In a previous study we presented data indicating that the expanded population of CD4(-)CD8(-) (DN) alphabeta T cells in TCRalpha-chain-transgenic mice was partially if not entirely derived from gammadelta T cell lineage cells. The development of both gammadelta T cells and DN alphabeta T cells is poorly understood; therefore, we thought it would be important to identify the immediate precursors of
Measurements are presented of inclusive charm and beauty cross sections in e(+)p collisions at HERA for values of photon virtuality 12 <= Q(2) = 60 GeV2 and of the Bjorken scaling variable 0.0002 <= x <= 0.005. The fractions of events containing charm and beauty quarks are determined using a method based on the impact parameter, in the transverse plane, of tracks to the primary vertex, as measured
Immunoglobulin G (IgG) glycosylation modulates antibody activity and represents a major source of heterogeneity within antibody preparations. Depending on their glycosylation pattern, individual IgG glycovariants present in recombinant antibody preparations may trigger effects ranging from enhanced pro-inflammatory activity to increased anti-inflammatory activity. In contrast, reduction of IgG gly
Protein kinase C (PKC) plays a prominent role in immune signaling, and the paradigms for isoform selective signaling are beginning to be elucidated. Real-time microscopy was combined with molecular and biochemical approaches to demonstrate a role for PKC-epsilon in Fcgamma receptor (FcgammaR)-dependent phagocytosis. RAW 264.7 macrophages were transfected with GFP-conjugated PKC isoforms, and GFP m
OBJECTIVE: To investigate the possible role of FCGR2A 519A>G and FCGR3A 559A>C functional polymorphisms in the genetic predisposition to susceptibility to systemic sclerosis (SSc) or clinical phenotype. METHODS: A total of 1566 patients with SSc and 2271 geographically matched controls were included in our study. We analyzed the genotype and allele frequencies of the FCGR2A 519A>G and FCGR3A 559A>
In order to suggest improvements for the logistics of STARKA, we felt that we had to analyze all the activities which were related to STARKA's logistic processes. Our primary analysis consisted of a rough but comprehensive description of different functions in the company, and the relationship between them. This was performed by following a typical order through the company to see which functi
The aim of this project was to examine if it is feasible to develop and apply a reuse concept regarding clean in place (CIP) processes. The concept is based on different topics such as lim-itation, structure, future and reliability. Three CIP processes were chosen to represent the wide variety of cleaning processes available to the food and pharmaceutical industries, Single use Food, Recovery Food
Att ingå långvariga avtal är förenat med vissa svårigheter, speciellt eftersom det är problematiskt att på förhand förutse framtida omständigheter som kan komma att påverka ett avtal. Som utgångspunkt gäller pacta sunt servanda och möjligheten att förändra ett redan ingånget avtal har varit starkt begränsat i princip alla rättsordningar. I svensk avtalsrätt är det främst 36 § AvtL som kan användasTo enter long-term contracts is subject to certain issues, especially because it may be difficult to prospectively foresee future circumstances, that may affect the contract. The main legal principle that applies is pacta sunt servanda but the possibility to modify a contract has always been very limited in almost all legal systems. In Swedish contract law, it’s mainly the general clause 36 § AvtL
Den mest kännetecknande aspekten av avtalsrätten är dess långtgående avtalsfrihet, vilken möjliggör att kommersiella avtal kan influeras av hur avtal konstrueras inom andra rättssystem. I avtalsrätten syns denna utveckling tydligt i och med förekomsten av boilerplate klausuler i kommersiella avtal. En av dessa klausuler är integrationsklausulen. Den vedertagna uppfattningen om innebörden av en iThe most characteristic aspect of Contract Law is its far-reaching freedom of contract, which makes it possible for commercial agreements to have an influence on how contracts are construed within other legal systems. In Contract Law this development is apparent with the use of boilerplate clauses in commercial agreements. One of these clauses is the integration clause. The recognized understandi
Abstract Sweden has experienced a dramatic change from being a belligerent greatpower in the 17th and 18th centuries to becoming a peaceful small nation in the 19th and 20th centuries. The country has not been involved in war for over 180 years. Modern Sweden has established more or less peaceful relations with other countries. This thesis focuses on the 19th century as beeing an important period
Sandra Lundin läser sin sista termin på masterprogrammet i tillämpad kulturanalys. Hon lockades från början till programmet eftersom det var inriktat på praktisk tillämpning och självständigt etnografiskt arbete.Sandra Lundin is completing her final term on the Master’s Programme in Applied Cultural Analysis. She was initially drawn to the programme’s emphasis on practical application and independent ethnographic work.
