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Background: MicroRNA-379 (miR-379) has been reported to play a tumour-suppressing role in several cancer types. Our previous work demonstrated that miR-379 overexpression attenuates the metastatic spread of prostate cancer (PCa) both in vitro and in vivo. However, the underlying mechanisms remain poorly understood. Methods: To elucidate the mechanisms by which miR-379 affects metastases, we pe
Lunds universitets centrum för studier av uthållig samhällsutveckling, LUCSUS, är en plattform för utbildning, forskning och samarbete i frågor som rör hållbar utveckling.
Integrating immigrants into the labor market is a challenge for the city of Malmö, impacting its performance to achieve Sustainable Development Goals related to Decent Jobs and Reduced Inequalities. This thesis explores the role of 3 social innovations in addressing this challenge, guided by the Multi-Level Perspective. The research explores unique approaches these enterprises apply to create empl
The Paleogene history of biogenic opal accumulation in the North Atlantic provides insight into both the evolution of deepwater circulation in the Atlantic basin and weathering responses to major climate shifts. However, existing records are compromised by low temporal resolution and/or stratigraphic discontinuities. In order to address this problem, we present a multi-site, high-resolution record
Background: The Company sells many of its products through external sales channels. Two important goals for the Company are to increase the sales of components and decrease the cost of sales by making the ordering processes more effective. The Company is today vending a limited number of components and products through e-commerce to the sales channels. One of these products, in this report referre
BACKGROUND: Pathways for intravenously administered gadolinium-based-contrast-agents (GBCAs) entering cerebrospinal-fluid (CSF) circulation in the human brain are not well-understood. The blood-CSF-barrier (BCSFB) in choroid-plexus (CP) has long been hypothesized to be a main entry-point for intravenous-GBCAs into CSF. Most existing studies on this topic were performed in animals and human patient
When the rural Aymara migrate to El Alto they experience a cultural alienation as their culture and identity is contested by the global influences and western values of the city. The migrants have to reconstruct their identity in a process of identity-formation, which can be located on a range between the opposing tendencies of assimilation and revalorization. Revalorization or to revalue, is to a
The endogenous chemokines CCL19 and CCL21 signal via their common receptor CCR7. CCL21 is the main lymph node homing chemokine, but a weak chemo-attractant compared to CCL19. Here we show that the 41-amino acid positively charged peptide, released through C-terminal cleavage of CCL21, C21TP, boosts the immune cell recruiting activity of CCL21 by up to 25-fold and the signaling activity via CCR7 by
There is uncertainty about whether AI-generated output can and should be protected under EU copyright law and, in that case, who should obtain the rights. This thesis examines this legal issue by interpreting the legal text especially the InfoSoc Directive, case law and by considering legal scholarships. It has been established in the thesis that an AI-generated output can be considered protectabl
The heat requirement of a building can turn out to be greater than was calculated at the design stage. The reason for this may be that heat transport though the building envelope is greater than expected. This in turn can be due to the structure not fulfilling the design requirements in respect of windtightness and airtightness. In addition, there may be defects in the quality of the workmanship o
Background: Heating is a key challenge for Europe’s decarbonisation goals, accounting for a large share of energy use and emissions while shaping everyday life, comfort, and vulnerability. This article compares home heating transitions in Finland, Romania, Sweden, and the United Kingdom through an integrated framework combining energy democracy, energy citizenship, and energy justice. The study ex
Imagining how contemporary conflicts have divided societies in the recent times put one in a position to think of possibilities that will improve the activities of reconciliation initiatives for a lasting peaceful coexistence in the aftermath of conflicts. In Rwanda series of conflicts have emerged since the end of colonial rule till the genocide in 1994 calling for a necessary transitional justic
Research in music, sound art and sound studies is not only a matter of listening and experiencing auditory phenomena. Neither is it limited to the study of scores, graphic notations or sonograms. With the still increasing expansion of practice-based research methods, many artists and scholars of music, sound art and sound studies now gain their knowledge through their creative practice, or through
The Norma Research Programme is an interdisciplinary research environment at the Faculty of Law, and a research centre affiliated with the Labour Law Research Network (LLRN). The focus is on the legal regulation of everyday life and social integration at national, EU, and international level, and on labour markets, social welfare, ageing societies, and families. The research environment includes a
Professor Contact details Email: helena [dot] filipsson [at] mgeo [dot] lu [dot] se Phone: +46 46 222 82 26 Mobile: +46 76 777 25 66Organisation Department of Earth and Environmental Sciences (MGeo) Visiting address: Geocentrum 2, Lund Room number: 386 Service point: 16 WebpageHelena Filipssons profile in Lund University research portalOther affiliations Member of Strategic Research Area BECC: Bio
https://www.geology.lu.se/helena-filipsson - 2026-07-06
