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This study delves into the landscape of health applications within online markets. These applications, offering health-related functionalities, have become integral to the lives of European citizens. The transformation of healthcare delivery, accelerated by the pace of modern life and accentuated by the COVID-19 pandemic, has elevated health applications from conveniences to essential tools capabl
Abstract in PolishW latach 1945–1946 dziewięcioro byłych polskich więźniów niemieckich obozów koncentracyjnych (jedna osoba pochodzenia żydowskiego i osiem nieżydowskiego) przebywających na prawach uchodźców w Szwecji otrzymało zadanie spisania doświadczeń wojennych i prześladowań innych Polaków pochodzenia żydowskiego i nieżydowskiego dla potrzeb historii i sprawiedliwości. Choć żadna z tych osóbIn 1945–1946, nine Polish former prisoners of Nazi concentration camps (one Jewish and eight non-Jewish) living in Sweden as refugees were employed to record other Jewish and non-Jewish Poles’ experiences of persecution for history and justice. Although none of these individuals were psychologists, they believed recording the psychological aspects of witnessing was essential to their documentation
Fifty-eight million individuals worldwide are affected by chronic hepatitis C virus (HCV) infection, a primary driver of liver cancer for which no vaccine is available1. The HCV envelope proteins E1 and E2 form a heterodimer (E1/E2), which is the target for neutralizing antibodies2. However, the higher-order organization of these E1/E2 heterodimers, as well as that of any Hepacivirus envelope prot
Risk stratification has gained an increasing role in predicting outcomes and guiding the treatment of patients with pulmonary arterial hypertension (PAH). The most predictive prognostic factors are three noninvasive parameters (World Health Organization functional class, 6-min walk distance and natriuretic peptides) that are included in all currently validated risk stratification tools. However, s
Background and purpose: Although the diagnostic accuracy of 18F-fluorodeoxyglucose – positron emission tomography/computed tomography (18F-FDG-PET/CT) for breast cancer (BC) has been well studied, few studies have evaluated the impact of 18F-FDG-PET/CT on BC patient care. This study aimed to investigate restaging and 18F-FDG-PET/CT-induced changes in clinical decision-making in patients with BC. M
Introduction: The complement and kallikrein-kinin systems (KKS) are both activated during vascular inflammation, and there are many known interactions between the two systems. This study investigated if KKS activation induced complement activation on endothelial cells, and if activation was dependent on bradykinin B1 receptor (B1R) signaling.Methods: KKS was activated in normal human serum by kaol
BACKGROUND: Moderate differences in efficacy between adjuvant chemotherapy regimens for breast cancer are plausible, and could affect treatment choices. We sought any such differences.METHODS: We undertook individual-patient-data meta-analyses of the randomised trials comparing: any taxane-plus-anthracycline-based regimen versus the same, or more, non-taxane chemotherapy (n=44,000); one anthracycl
Observations find a median star formation efficiency per free-fall time in Milky Way Giant Molecular Clouds (GMCs) of the order of ϵff∼1 per cent with dispersions of ∼0.5dex. The origin of this scatter in ϵff is still debated and difficult to reproduce with analytical models. We track the formation, evolution and destruction of GMCs in a hydrodynamical simulation of a Milky Way-like galaxy and by
We present smoothed particle hydrodynamic models of the interactions in the compact galaxy group, Stephan’s Quintet. This work is extension of the earlier collisionless N-body simulations of Renaud et al. in which the large-scale stellar morphology of the group was modelled with a series of galaxy–galaxy interactions in the simulations. Including thermohydrodynamic effects in this work, we further
Preliminary mobile was considered to be a device to make human connections easier. But today the consumption of this device has been evolved to a platform for gaming, web surfing and GPS-enabled application capabilities. Embedding GPS in handheld devices, altered them to significant trajectory data gathering facilities. Raw GPS trajectory data is a series of points which contains hidden informatio
Informal caregiving is increasingly considered a health care delivery-resource within the North European welfare states. While ‘informal’ often refers to non-professional, ‘caregiving’ connotes both affective concern (caring about) and practical action (caring for). This duality of meanings, however, often refers to the one direction in which care is given. Care, we suggest, is relational and also
To identify homeless people with chronic kidney disease (CKD) who were at highest risk for end-stage renal disease (ESRD), we studied 982 homeless and 15,674 domiciled people with CKD receiving public health care. We developed four risk prediction models for the primary outcome of ESRD. Overall, 71 homeless and 888 domiciled people progressed to ESRD during follow-up (median: 6.6 years). Homeless
Solid oxide fuel cells (SOFCs) directly convert chemical energy to electricity with high electrical efficiency. It involves gas transport through the porous electrode to the three-phase boundaries (TPB). The tortuosity of gas transport relates the bulk diffusion of gas in free space to the effective diffusion coefficient of gas migrating through a porous material. Therefore, determining the tortuo
We formulate a version of the low-scale Majoron model equipped with an inverse seesaw mechanism featuring lepton-number preserving dimension-6 operators in the scalar potential. Contrary to its dimension-4 counterpart, we find that the model can simultaneously provide light and ultralight Majorons, neutrino masses and their mixing, while featuring strong first-order cosmological phase transitions
This article discusses an important panel held at ICIS 2011 in Shanghai to mark over thirty years of an ICIS institution, the ICIS Women's Breakfast. The panel addressed the controversial question-is there still a need for the ICIS Women's Breakfast? Panelists were asked if the ICIS Women's Breakfast could be seen as divisive, and if women's issues are different from issues of diversity such as ra
Diabetes is a highly heterogeneous condition; yet, it is diagnosed by measuring a single blood-borne metabolite, glucose, irrespective of aetiology. Although pragmatically helpful, disease classification can become complex and limit advances in research and medical care. Here, we describe diabetes heterogeneity, highlighting recent approaches that could facilitate management by integrating three d
Palaeoecological records provide a rich source of information to explore how plant distribution ranges respond to climate changes, but their use is complicated by the fact that, especially when based on pollen data, they are often spatially too inaccurate to reliably determine past range limits. To solve this problem, we focus on hazel (Corylus avellana), a tree species with large and heavy fruits
The incidence of invasive Haemophilus influenzae type b (Hib) disease has significantly decreased since the introduction of an efficient vaccine against Hib. However, in contrast to Hib, infections caused by H. influenzae serotype f (Hif) are emerging. We recently did a whole genome sequencing of an invasive Hif isolate, and reported that Hif interacts with factor H by expressing protein H (PH). I
